Lymphoproliferative syndrome with autoimmunity: A possible genetic basis for dominant expression of the clinical manifestations.
Frédéric Rieux-Laucat,S Blachère,S Danielan,J P de Villartay,Matias Oleastro,Eric Solary,Brigitte Bader-Meunier,Peter D. Arkwright,C. Pondaré,Françoise Bernaudin,Helen Chapel,Susan Nielsen,M Berrah,A Fischer,F Le Deist +14 more
TLDR
It was found that lymphoproliferative manifestations resolved with age, whereas immunological disorders persisted, suggesting that Fas-mediated apoptosis plays a more important role in lymphocyte homeostasis in early childhood than later on in life.About:
This article is published in Blood.The article was published on 1999-10-15 and is currently open access. It has received 146 citations till now. The article focuses on the topics: Autoimmune lymphoproliferative syndrome & Lymphoproliferative disorders.read more
Citations
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Mutations inFasAssociated withHuman Lymphoproliferative Syndrome and Autoimmunity
P. Lane,M. Lohoff,F. Rieux-Laucat,F. LeDeist,C. Hivroz,A. G. Roberts,K. M. Debatin,A. Fischer +7 more
TL;DR: Fas expression and function were analyzed in three children with a lymphoproliferative syndrome and may provide a molecular basis for some autoimmune diseases in humans.
Journal ArticleDOI
Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop.
Joao Bosco Oliveira,Jack J. Bleesing,Umberto Dianzani,Thomas A. Fleisher,Elaine S. Jaffe,Michael J. Lenardo,Frédéric Rieux-Laucat,Richard M. Siegel,Helen C. Su,David T. Teachey,V. Koneti Rao +10 more
TL;DR: It is hoped that harmonizing the diagnosis and classification of ALPS will foster collaborative research and better understanding of the pathogenesis of autoimmune cytopenias and B-cell lymphomas.
Journal ArticleDOI
Dissecting lipid raft facilitated cell signaling pathways in cancer.
TL;DR: In view of this, insight is focused into the cancer cell physiology caused by the lipid rafts mediated signals and their receptors, and the downstream transmitters, either proliferative or death-inducing.
Journal ArticleDOI
Autoimmune Lymphoproliferative Syndrome with Somatic Fas Mutations
Eliska Holzelova,Cédric Vonarbourg,Marie-Claude Stolzenberg,Peter D. Arkwright,Françoise Selz,Anne Marie Prieur,Stéphane Blanche,Jirina Bartunkova,Etienne Vilmer,Alain Fischer,Françoise Le Deist,Frédéric Rieux-Laucat +11 more
TL;DR: Somatic heterozygous mutations of Fas can cause a sporadic form of ALPS by allowing lymphoid precursors to resist the normal process of cell death.
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Autoimmune hemolytic anemia in chronic lymphocytic leukemia: clinical, therapeutic, and prognostic features
Francesca Romana Mauro,Robert Foa,R Cerretti,Diana Giannarelli,Serelina Coluzzi,Franco Mandelli,Gabriella Girelli +6 more
TL;DR: It is indicated that in CLL, AHA is a rare event with no independent effect on survival for which steroids, associated with CB if required, and a careful management of infections may successfully control the 2 conditions.
References
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Book
A Laboratory manual
TL;DR: To develop a program to print the barcodes using two commonly uses command sets and hence evaluates their ease of use for such applications, students should be able to program dot matrix printers, by manipulating bit level information and ink jet printers using page description language, such as PCL.
Journal ArticleDOI
Death receptors: signaling and modulation
Avi Ashkenazi,Vishva M. Dixit +1 more
TL;DR: Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival.
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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
TL;DR: A flow cytometric method for measuring the percentage of apoptotic nuclei after propidium iodide staining in hypotonic buffer is developed and shown an excellent correlation with the results obtained with both electrophoretic and colorimetric methods.
Journal ArticleDOI
The Fas Death Factor
Shigekazu Nagata,Pierre Golstein +1 more
TL;DR: Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells.
Journal ArticleDOI
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.
Marta Muzio,Arul M. Chinnaiyan,Frank C. Kischkel,Karen O'Rourke,Andrej Shevchenko,Jian Ni,Carsten Scaffidi,James D. Bretz,Mei Zhang,Reiner L. Gentz,Matthias Mann,Peter H. Krammer,Marcus E. Peter,Vishva M. Dixit +13 more
TL;DR: This work utilized nano-electrospray tandem mass spectrometry to identify CAP3 and CAP4, components of the CD95 (Fas/APO-1) death-inducing signaling complex, and found a novel 55 kDa protein, designated FLICE, which has homology to both FADD and the ICE/CED-3 family of cysteine proteases.
Related Papers (5)
The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis.
Sharon E. Straus,Elaine S. Jaffe,Jennifer M. Puck,Janet K. Dale,Keith B. Elkon,Angela Rösen-Wolff,Anke M J Peters,Michael C. Sneller,Claire W. Hallahan,Jin Wang,Roxanne Fischer,Christine M. Jackson,Albert Y. Lin,Caroline Bäumler,Elke Siegert,Alexander Marx,Akshay K. Vaishnaw,Tamara Grodzicky,Thomas A. Fleisher,Michael J. Lenardo +19 more