Metabolic activation of bisphenol A by rat liver S9 fraction.
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TLDR
The present results clearly indicate that BPA is metabolically activated in terms of estrogenicity under the conditions existing only with combined rat liver microsomes and cytosol.About:
This article is published in Toxicological Sciences.The article was published on 2001-08-01 and is currently open access. It has received 132 citations till now. The article focuses on the topics: S9 fraction & Methoxychlor.read more
Citations
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Journal ArticleDOI
Bisphenol A--sources, toxicity and biotransformation.
TL;DR: Biotransformation of BPA in animals, plants and microorganisms, resulting in the formation of various metabolites that exhibit different from BPA toxicity will be described.
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Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds.
Shigeyuki Kitamura,Tomoharu Suzuki,Seigo Sanoh,Ryuki Kohta,Norimasa Jinno,Kazumi Sugihara,Shin'ichi Yoshihara,Nariaki Fujimoto,Hiromitsu Watanabe,Shigeru Ohta +9 more
TL;DR: The results suggest that the 4-hydroxyl group of the A- phenyl ring and the B-phenyl ring of BPA derivatives are required for these hormonal activities, and substituents at the 3,5-positions of the phenyl rings and the bridging alkyl moiety markedly influence the activities.
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NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A
Robert E. Chapin,Jane Adams,Kim Boekelheide,L. Earl Gray,Simon W. Hayward,Peter S.J. Lees,Barry S. McIntyre,Kenneth M. Portier,Teresa M. Schnorr,Sherry G. Selevan,John G. Vandenbergh,Susan Woskie +11 more
TL;DR: This research presents a meta-analyses of the immune system’s response to exposure to radiation and shows clear patterns of decline in the immune systems of men and women aged 65 and over.
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Biodegradation or metabolism of bisphenol A: from microorganisms to mammals.
TL;DR: Bisphenol A biodegradations or metabolisms by many organisms from microorganisms to mammals were referred, and generally, BPA metabolism by organisms leads to detoxication of BPA.
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Determination of Free and Conjugated Forms of Bisphenol A in Human Urine and Serum by Liquid Chromatography–Tandem Mass Spectrometry
TL;DR: This is the first report on the occurrence of BPAG and BPADS in human serum, and the method was applied to measure six target chemicals in urine and serum samples collected from volunteers in Albany, New York.
References
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Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test
TL;DR: The methods described include the standard plate test, the use and storage of the bacterial tester strains, preparation and use of the liver homogenates, and the methods of inducing the rats for elevated microsomal enzyme activity.
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Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving
TL;DR: The findings raise the possibility that unsuspected estrogenic activity in the form of BPA may have an impact on experiments employing media autoclaved in polycarbonate flasks, and it remains to be determined whether BPA derived from consumer products manufactured from poly carbonate could significantly contribute to the pool of estrogenic substances in the environment.
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Estrogenic activity of surfactants and some of their degradation products assessed using a recombinant yeast screen
TL;DR: An estrogen-inducible screen was developed in yeast in order to assess whether surfactants and their major degradation products are estrogenic, and one class of surfactant classes degrade to persistent metabolites that were weakly estrogenic.
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Estrogenicity of resin-based composites and sealants used in dentistry.
Nicolás Olea,Rosa Pulgar,Pilar Perez,Fátima Olea-Serrano,Ana Rivas,Arantzazu Novillo-Fertrell,V. Pedraza,Ana M. Soto,Carlos Sonnenschein +8 more
TL;DR: The use of bis-GMA-based resins in dentistry, and particularly the use of sealants in children, appears to contribute to human exposure to xenoestrogens.
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Xenoestrogens released from lacquer coatings in food cans.
TL;DR: It is apparent that all estrogenic activity in these cans was due to bisphenol-A leached from the lacquer coating, and the use of plastic in food-packaging materials may require closer scrutiny to determine whether epoxy resins and polycarbonates contribute to human exposure to xenoestrogens.