Metabolic Interactions in the Tumor Microenvironment
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TLDR
The focus of this review is on the remodeling of the tumor microenvironment that leads to pathophysiologic interactions that are influenced and shaped by metabolism.About:
This article is published in Trends in Cell Biology.The article was published on 2017-11-01 and is currently open access. It has received 552 citations till now. The article focuses on the topics: Tumor microenvironment.read more
Citations
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Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context
TL;DR: In this paper , the authors demonstrate that the loss of GO2 disturbs redox homeostasis and halts proliferation of pancreatic ductal adenocarcinoma (PDA) cells.
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Reconciling environment-mediated metabolic heterogeneity with the oncogene-driven cancer paradigm in precision oncology.
TL;DR: This Review describes how TME-mediated metabolic heterogeneities actively participate to therapeutic failure and describes the role of mitochondrial metabolism, in particular oxidative phosphorylation (OXPHOS), to support the growth and survival of therapy-resistant tumor cells in a variety of cancers.
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The pathways related to glutamine metabolism, glutamine inhibitors and their implication for improving the efficiency of chemotherapy in triple-negative breast cancer.
TL;DR: The literature suggests that the addiction of TNBC to Gln could facilitate the proliferation and invasiveness of these cancers, and Gln metabolism inhibitors, such as CB-839, could be applied to manage the carcinogenic properties of T NBC.
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Cancer-Associated Fibroblast Functions as a Road-Block in Cancer Therapy.
TL;DR: In this article, the authors introduce cancer-associated fibroblasts (CAF) as a crucial component of the tumor microenvironment (TME) and investigate the role of CAF in mediating resistance to different modes of therapies.
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Secreted Protein Acidic and Rich in Cysteine: Metabolic and Homeostatic Properties beyond the Extracellular Matrix Structure
TL;DR: A spotlight is put on selected, metabolic and homeostatic properties beyond the known properties of ECM and SPARC that would indicate an adaptation of the metabolism to meet the needs of the changes that the tissues undergo.
References
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TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
TL;DR: Emerging evidence supporting an alternative hypothesis is reviewed—that certain antiangiogenic agents can also transiently “normalize” the abnormal structure and function of tumor vasculature to make it more efficient for oxygen and drug delivery.
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Molecular mechanisms and clinical applications of angiogenesis
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies.
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The Emerging Hallmarks of Cancer Metabolism
TL;DR: This Perspective has organized known cancer-associated metabolic changes into six hallmarks: deregulated uptake of glucose and amino acids, use of opportunistic modes of nutrient acquisition, useof glycolysis/TCA cycle intermediates for biosynthesis and NADPH production, increased demand for nitrogen, alterations in metabolite-driven gene regulation, and metabolic interactions with the microenvironment.
Journal ArticleDOI
Coordinated regulation of myeloid cells by tumours
TL;DR: This work considers myeloid cells as an intricately connected, complex, single system and focuses on how tumours manipulate the myeloids system to evade the host immune response.
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