Metabolic Interactions in the Tumor Microenvironment
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TLDR
The focus of this review is on the remodeling of the tumor microenvironment that leads to pathophysiologic interactions that are influenced and shaped by metabolism.About:
This article is published in Trends in Cell Biology.The article was published on 2017-11-01 and is currently open access. It has received 552 citations till now. The article focuses on the topics: Tumor microenvironment.read more
Citations
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Journal ArticleDOI
Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies.
TL;DR: Experimental evidence that microenvironmental factors regulate tumor metabolism is focused on, and the implications for choosing appropriate model systems and experimental approaches are highlighted.
Journal ArticleDOI
Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response.
TL;DR: In this article, the authors defined the functions of the spatial architecture of the tumor immune microenvironment (TIME) in tumor biology and the effects of the gradient of extracellular nonspecific chemicals (ENSCs) on the TIME.
Journal ArticleDOI
Metabolic Plasticity in Chemotherapy Resistance.
TL;DR: The best-known cancer metabolic profiles are gone and several studies that reported tumors sensitization to chemotherapy by modulating metabolic pathways are discussed to help to rationalize the use of metabolic modulators to overcome therapy resistance.
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Interactions in the (Pre)metastatic Niche Support Metastasis Formation.
TL;DR: Current knowledge on the interactions in the tumor environment that result in (pre)metastatic niche formation are summarized, specifically in the context of tumor secreted factors, extracellular matrix, immune as well as stromal cells, and nutrient availability.
Journal ArticleDOI
Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
Weihua Zhou,Yangyang Yao,Yangyang Yao,Andrew J. Scott,Kari Wilder-Romans,Joseph Dresser,Christian K. Werner,Hanshi Sun,Drew Pratt,Peter Sajjakulnukit,Shuang G. Zhao,Mary A. Davis,Barbara S. Nelson,Christopher J. Halbrook,Li Zhang,Francesco Gatto,Yoshie Umemura,Angela K. Walker,Maureen Kachman,Jann N. Sarkaria,Jianping Xiong,Meredith A. Morgan,Alnawaz Rehemtualla,Maria G. Castro,Pedro R. Lowenstein,Sriram Chandrasekaran,Theodore S. Lawrence,Costas A. Lyssiotis,Daniel R. Wahl +28 more
TL;DR: It is shown that glioblastoma radiation resistance is promoted by purine metabolism and can be overcome by inhibitors of purine synthesis, and that inhibiting purines synthesis may be a promising strategy to overcome therapy resistance in this genomically heterogeneous disease.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
TL;DR: Emerging evidence supporting an alternative hypothesis is reviewed—that certain antiangiogenic agents can also transiently “normalize” the abnormal structure and function of tumor vasculature to make it more efficient for oxygen and drug delivery.
Journal ArticleDOI
Molecular mechanisms and clinical applications of angiogenesis
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies.
Journal ArticleDOI
The Emerging Hallmarks of Cancer Metabolism
TL;DR: This Perspective has organized known cancer-associated metabolic changes into six hallmarks: deregulated uptake of glucose and amino acids, use of opportunistic modes of nutrient acquisition, useof glycolysis/TCA cycle intermediates for biosynthesis and NADPH production, increased demand for nitrogen, alterations in metabolite-driven gene regulation, and metabolic interactions with the microenvironment.
Journal ArticleDOI
Coordinated regulation of myeloid cells by tumours
TL;DR: This work considers myeloid cells as an intricately connected, complex, single system and focuses on how tumours manipulate the myeloids system to evade the host immune response.
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