Metabolic Interactions in the Tumor Microenvironment
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TLDR
The focus of this review is on the remodeling of the tumor microenvironment that leads to pathophysiologic interactions that are influenced and shaped by metabolism.About:
This article is published in Trends in Cell Biology.The article was published on 2017-11-01 and is currently open access. It has received 552 citations till now. The article focuses on the topics: Tumor microenvironment.read more
Citations
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Longitudinal Immune Profiling Reveals Unique Myeloid and T-cell Phenotypes Associated with Spontaneous Immunoediting in a Prostate Tumor Model.
Casey Ager,Aleksandar Obradovic,Juan Arriaga,Matthew G. Chaimowitz,Andrea Califano,Cory Abate-Shen,Charles G. Drake +6 more
TL;DR: In this paper, the authors used high-dimensional flow cytometry to study the role of lymphoid and myeloid populations in the cancer immunoediting process and highlight a role for multi-dimensional, flow-based analyses to more deeply understand immune cell dynamics in the tumor microenvironment.
Journal ArticleDOI
Metabolic Constrains Rule Metastasis Progression.
TL;DR: The latest evidence that claim the importance of metabolic adaptation for cancer progression is discussed, to precisely elucidate if and how metabolic reprogramming drives acquisition of cancer-specific adaptive phenotypes might pave the way to new therapeutic strategies by combining chemotherapy with metabolic drugs for better cancer eradication.
Journal ArticleDOI
Regulation and role of CAMKK2 in prostate cancer
Thomas L. Pulliam,Pavithr Goli,Dominik Awad,Chen Liangbiao Meng Lin,Sandi R. Wilkenfeld,Daniel E. Frigo +5 more
TL;DR: Evidence supporting an oncogenic role of CAMKK2 is presented, mechanisms of regulation and emerging non-cell-autonomous roles of CAMK2 are discussed, and the potential use of CamKK2 as a biomarker and/or therapeutic target in prostate cancer is discussed.
Journal ArticleDOI
Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached
Daniel J. Wilcock,Andrew P. Badrock,Chun-wing Wong,Rhys Owen,Melissa Guerin,Andrew D. Southam,Hannah Johnston,Brian A. Telfer,Paul Fullwood,Joanne Watson,Harriet R. Ferguson,Jennifer Ferguson,Gavin R. Lloyd,Andris Jankevics,Warwick B. Dunn,Claudia Wellbrock,P. Lorigan,Craig J. Ceol,Chiara Francavilla,Michael S. Smith,Adam Hurlstone +20 more
TL;DR: In this paper , the authors demonstrate that diacylglycerol O-acyltransferase 1 (DGAT1) is frequently upregulated in melanoma, allowing melanoma cells to tolerate excess FA.
References
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Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
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TL;DR: Preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies.
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TL;DR: This Perspective has organized known cancer-associated metabolic changes into six hallmarks: deregulated uptake of glucose and amino acids, use of opportunistic modes of nutrient acquisition, useof glycolysis/TCA cycle intermediates for biosynthesis and NADPH production, increased demand for nitrogen, alterations in metabolite-driven gene regulation, and metabolic interactions with the microenvironment.
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Coordinated regulation of myeloid cells by tumours
TL;DR: This work considers myeloid cells as an intricately connected, complex, single system and focuses on how tumours manipulate the myeloids system to evade the host immune response.
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