Metabolic Interactions in the Tumor Microenvironment
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TLDR
The focus of this review is on the remodeling of the tumor microenvironment that leads to pathophysiologic interactions that are influenced and shaped by metabolism.About:
This article is published in Trends in Cell Biology.The article was published on 2017-11-01 and is currently open access. It has received 552 citations till now. The article focuses on the topics: Tumor microenvironment.read more
Citations
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Metal Oxide Laser Ionization Mass Spectrometry Imaging (MOLI MSI) Using Cerium(IV) Oxide.
Sankha S. Basu,Madison H McMinn,Madison H McMinn,Begoña Gimenez-Cassina Lopez,Michael S. Regan,Elizabeth C. Randall,Amanda R Clark,Christopher Cox,Nathalie Y. R. Agar,Nathalie Y. R. Agar +9 more
TL;DR: The development and utilization of CeO2 as an MSI catalyst is presented and described for the first time and its potential for spatially resolved fatty acyl analysis, characterization of fatty Acyl composition in tumors, and its Potential for pathogen detection directly from tissue is highlighted.
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Metabolic Interplay between the Immune System and Melanoma Cells: Therapeutic Implications
TL;DR: In this paper, the authors summarize novel tumor metabolic pathways and tumor-host metabolic crosstalk mechanisms leading to melanoma progression and drug resistance, with an overview on their translational potential as novel therapeutic targets.
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HMGCR inhibition stabilizes the glycolytic enzyme PKM2 to support the growth of renal cell carcinoma.
TL;DR: The authors showed that the inhibition of 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) could accelerate the development of RCC tumors by lactate accumulation and angiogenesis in animal models.
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Simulations of tumor growth and response to immunotherapy by coupling a spatial agent-based model with a whole-patient quantitative systems pharmacology model
Alvaro Ruiz-Martinez,Chang Gong,Han-Ying Wang,Richard Jove,Haoyang Mi,Holly H. C. Kimko,Aleksander S. Popel +6 more
TL;DR: In this paper , a spatial QSP (spQSP) model was extended to analyze tumor growth dynamics and its response to immunotherapy at different spatio-temporal scales.
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Metabolic Reprogramming by Dual-targeting Biomimetic Nanoparticles for Enhanced Tumor Chemo-Immunotherapy.
Shuya Zang,Kexin Huang,Jiaxin Li,Kebai Ren,Ting Li,Xuan He,Yuan Tao,Jiao He,Ziyan Dong,Man Li,Qin He +10 more
TL;DR: In this paper , a biomimetic nanocarrier is designed by coating solid lipid nanoparticles containing chemotherapeutic paclitaxel (PTX) and glycolysis inhibitor PFK15 with hybrid membranes of cancer cells and activated fibroblasts.
References
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TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
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Molecular mechanisms and clinical applications of angiogenesis
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies.
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The Emerging Hallmarks of Cancer Metabolism
TL;DR: This Perspective has organized known cancer-associated metabolic changes into six hallmarks: deregulated uptake of glucose and amino acids, use of opportunistic modes of nutrient acquisition, useof glycolysis/TCA cycle intermediates for biosynthesis and NADPH production, increased demand for nitrogen, alterations in metabolite-driven gene regulation, and metabolic interactions with the microenvironment.
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Coordinated regulation of myeloid cells by tumours
TL;DR: This work considers myeloid cells as an intricately connected, complex, single system and focuses on how tumours manipulate the myeloids system to evade the host immune response.
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