Metabolic Interactions in the Tumor Microenvironment
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TLDR
The focus of this review is on the remodeling of the tumor microenvironment that leads to pathophysiologic interactions that are influenced and shaped by metabolism.About:
This article is published in Trends in Cell Biology.The article was published on 2017-11-01 and is currently open access. It has received 552 citations till now. The article focuses on the topics: Tumor microenvironment.read more
Citations
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Journal ArticleDOI
Cancer associated fibroblast: Mediators of tumorigenesis.
TL;DR: This review discusses the dynamic and reciprocal processes between stromal cells and extracellular matrices, using pancreatic cancer as an example, to demonstrate the inclusivity of the Somatic Mutation Theory and Tissue Organization Field Theory.
Journal ArticleDOI
Regulation of tumor-stroma interactions by the unfolded protein response.
Joanna Obacz,Tony Avril,Camila Rubio-Patiño,Jozef P. Bossowski,Aeid Igbaria,Jean-Ehrland Ricci,Eric Chevet +6 more
TL;DR: How the UPR coordinates the crosstalk between tumor and stromal cells, such as endothelial cells, normal parenchymal cells and immune cells, is discussed and the relevance of targeting ER stress/UPR signaling as a potential anticancer approach is discussed.
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Noncanonical TGFβ Pathway Relieves the Blockade of IL1β/TGFβ-Mediated Crosstalk between Tumor and Stroma: TGFBR1 and TAK1 Inhibition in Colorectal Cancer.
Natalia Guillén Díaz-Maroto,Rebeca Sanz-Pamplona,Mireia Berdiel-Acer,Francisco J. Cimas,Elena García,Samuel Gonçalves-Ribeiro,Nerea Albert,Gemma Garcia-Vicién,Gabriel Capellá,Victor Moreno,Ramon Salazar,Alberto Villanueva,David G. Molleví +12 more
TL;DR: The findings provide a translational rationale for the inhibition of TAK1 and TGFBR1 to remove the chemoprotection conferred by CAFs.
Journal ArticleDOI
How Autophagy Shapes the Tumor Microenvironment in Ovarian Cancer.
Alessandra Ferraresi,Carlo Girone,Andrea Esposito,Chiara Vidoni,Letizia Vallino,Eleonora Secomandi,Danny N. Dhanasekaran,Ciro Isidoro +7 more
TL;DR: The role of autophagy is presented, including tumor dormancy, chemoresistance, metastasis, and cell metabolism, with an emphasis on the bidirectional metabolic crosstalk between cancer cells and stromal cells in shaping the OC microenvironment.
Journal ArticleDOI
Selective imaging of solid tumours via the calcium-dependent high-affinity binding of a cyclic octapeptide to phosphorylated Annexin A2.
Duanwen Shen,Baogang Xu,Kexian Liang,Rui Tang,Gail Sudlow,Christopher Egbulefu,Kevin Guo,Avik Som,Rebecca C. Gilson,Dolonchampa Maji,Suman B. Mondal,LeMoyne Habimana-Griffin,Walter J. Akers,Shunqiang Li,Yang Liu,Sharon Bloch,Sid Kurkure,Zohar Nussinov,Alexander Seidel,Shaw-Wei D. Tsen,Samuel Achilefu +20 more
TL;DR: It is shown that, for a range of solid tumours, a cyclic octapeptide labelled with a near-infrared dye selectively binds to phosphorylated Annexin A2 (pANXA2), with high affinity at high levels of calcium, to serve as a tumour-selective imaging probe.
References
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TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
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