Journal ArticleDOI
Microglia and cell death in the developing mouse cerebellum.
TLDR
Cell death in the cerebellar medulla may serve to clear pathways for developing cortical afferents and efferents, or to increase the mechanical plasticity of the medulla during cortical folding.About:
This article is published in Developmental Brain Research.The article was published on 1990-09-01. It has received 212 citations till now. The article focuses on the topics: Cerebellum & Medulla.read more
Citations
More filters
Journal ArticleDOI
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease.
Marco Prinz,Josef Priller +1 more
TL;DR: The vulnerability of microglia to dysfunction is described and it is proposed that myelomonocytic cells might be used in the treatment of neurological and psychiatric disorders that are characterized by primary or secondary 'microgliopathy'.
Journal ArticleDOI
The myeloid cells of the central nervous system parenchyma.
TL;DR: A microglial cell is both a glial cell of the central nervous system and a mononuclear phagocyte, which belongs to the haematopoietic system and is involved in inflammatory and immune responses.
Journal ArticleDOI
Origin and differentiation of microglia.
TL;DR: The history of microglial cells is reviewed and the latest advances in the understanding of their origin, differentiation, and homeostasis are discussed, which provides new insights into their roles in health and disease.
Journal ArticleDOI
The origin and nature of ramified and amoeboid microglia: a historical review and current concepts.
Eng-Ang Ling,Wai Chow Wong +1 more
TL;DR: In this paper, it was shown that amoeboid microglia are derived from macrophages in the perinatal period, but through an intermediate stage as active macrophage in the postnatal period.
Journal ArticleDOI
Microglia promote the death of developing Purkinje cells.
José L. Marín-Teva,Isabelle Dusart,Catherine Colin,Annie Gervais,Nico van Rooijen,Michel Mallat +5 more
TL;DR: This study illustrates a mammalian form of engulfment-promoted cell death that links the execution of neuron death to the scavenging of dead cells and shows how microglia promote the death of developing neurons engaged in synaptogenesis.
References
More filters
Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Heavy metal intensification of DAB-based HRP reaction product
TL;DR: This communication describes this modification and includes a much simpler and faster means of carrying out the reaction, simplified by adding the metal salts directly to the phosphate buffered DAB solution in concentrations that barely saturate the medium with the salts.
Journal ArticleDOI
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo.
TL;DR: Rat bone marrow chimeras and encephalitogenic, major histocompatability--restricted T-helper lymphocytes were used to show that a subset of endogenous CNS cells, commonly termed "perivascular microglial cells," is bone marrow-derived and are fully competent to present antigen to lymphocytes in an appropriately restricted manner.