MIF does only marginally enhance the pro-regenerative capacities of DFO in a mouse-osteotomy-model of compromised bone healing conditions
Annemarie Lang,Quan Ouyang,Jonathan Stefanowski,Moritz Pfeiffenberger,Moritz Pfeiffenberger,Angelique Wolter,Angelique Wolter,Alexandra Damerau,Alexandra Damerau,Shabnam Hemmati-Sadeghi,Rainer Haag,Anja E. Hauser,Anja E. Hauser,Max Löhning,Max Löhning,Georg N. Duda,Paula Hoff,Paula Hoff,Paula Hoff,Katharina Schmidt-Bleek,Katharina Schmidt-Bleek,Timo Gaber,Timo Gaber,Timo Gaber,Frank Buttgereit,Frank Buttgereit,Frank Buttgereit +26 more
TLDR
In this article, the authors combined a well-known HIF-stabilizer (DFO) and a less known HIFenhancer (MIF) to synergistically induce improved fracture healing.About:
This article is published in Bone.The article was published on 2022-01-01 and is currently open access. It has received 7 citations till now. The article focuses on the topics: Bone healing & Bone healing.read more
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Coaxially Fabricated Dual‐Drug Loading Electrospinning Fibrous Mat with Programmed Releasing Behavior to Boost Vascularized Bone Regeneration
Jinjie Cui,Xingge Yu,Bin Yu,Xiuyi A. Yang,Zeyu Fu,Jianyu Wan,Min-Ying Zhu,Xudong Wang,Kaili Lin +8 more
TL;DR: Overall, the study suggests a low‐cost strategy to enhance vascularized bone regeneration by adjusting the behavior of angiogenesis and osteogenesis in time dimension.
Journal ArticleDOI
The decisive early phase of bone regeneration
Georg N. Duda,Sven Geissler,Sara Checa,Serafeim Tsitsilonis,Ansgar Petersen,Katharina Schmidt-Bleek +5 more
Journal ArticleDOI
Scaffold Guided Bone Regeneration for the Treatment of Large Segmental Defects in Long Bones
TL;DR: In this paper , a review of existing approaches for bone tissue regeneration is presented, including the requirements and properties of natural and synthetic biomaterials for bone reconstruction, their use in conjunction with cellular components and suitable growth factors, and strategies to improve vascularization and the translation of these regenerative concepts to in vivo applications.
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HIF-1α Regulates Bone Homeostasis and Angiogenesis, Participating in the Occurrence of Bone Metabolic Diseases
TL;DR: In this article , a review on the HIF-1α pathway and its possible mechanism of its involvement in the regulation of bone homeostasis and angiogenesis is presented, as well as the current experimental studies on the use of HIF1α in the prevention of bone metabolic diseases.
Journal ArticleDOI
A buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72 h in mouse femoral fracture models
Angelique Wolter,Christian H. Bucher,S. Kurmies,Viktoria Schreiner,Frank Konietschke,Katharina Hohlbaum,Robert Klopfleisch,Max Löhning,Christa Thöne-Reineke,Frank Buttgereit,Jörg Huwyler,Paulin Jirkof,Anna E. Rapp,Annemarie Lang +13 more
TL;DR: In this article , a microparticulate Buprenorphine formulation (BUP-Depot) for sustained release has been developed as a potential future alternative to standard formulations available in Europe.
References
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Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
TL;DR: In this paper, the authors identify a new capillary subtype in the murine skeletal system with distinct morphological, molecular and functional properties, which mediate growth of the bone vasculature, generate distinct metabolic and molecular microenvironments, maintain perivascular osteoprogenitors and couple angiogenesis to osteogenesis.
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Fracture healing: mechanisms and interventions
TL;DR: The developmental progression of fracture healing at the tissue, cellular and molecular levels is reviewed and strategies for fracture treatment that have been tested in animal models and in clinical trials or case series are presented.
Journal ArticleDOI
Fracture healing under healthy and inflammatory conditions
TL;DR: Evidence suggests that insufficient biomechanical conditions within the fracture zone can influence early local inflammation and impair bone healing, with particular emphasis on the role of inflammation.
Journal ArticleDOI
The hypoxia-inducible factor α pathway couples angiogenesis to osteogenesis during skeletal development
Ying Wang,Chao Wan,Lianfu Deng,Ximeng Liu,Xuemei Cao,Shawn R. Gilbert,Mary L. Bouxsein,Marie Claude Faugere,Robert E. Guldberg,Louis C. Gerstenfeld,Volker H. Haase,Randall S. Johnson,Ernestina Schipani,Thomas L. Clemens,Thomas L. Clemens +14 more
TL;DR: It is suggested that activation of the HIF alpha pathway in developing bone increases bone modeling events through cell-nonautonomous mechanisms to coordinate the timing, direction, and degree of new blood vessel formation in bone.
Journal ArticleDOI
Activation of the hypoxia-inducible factor-1α pathway accelerates bone regeneration
Chao Wan,Shawn R. Gilbert,Ying Wang,Xuemei Cao,Xing Shen,Girish Ramaswamy,Kimberly A. Jacobsen,Zainab S Al-Aql,Alan W. Eberhardt,Louis C. Gerstenfeld,Thomas A. Einhorn,Lianfu Deng,Thomas L. Clemens,Thomas L. Clemens +13 more
TL;DR: The HIF-1α pathway is identified as a critical mediator of neoangiogenesis required for skeletal regeneration and the application of HIF activators as therapies to improve bone healing is suggested.