Mitochondrial DNA copy number in human disease: the more the better?
Roberta Filograna,Roberta Filograna,Mara Mennuni,Mara Mennuni,David Alsina,David Alsina,Nils-Göran Larsson,Nils-Göran Larsson +7 more
Reads0
Chats0
TLDR
Current knowledge of the role of mtDNA copy number regulation in various types of human diseases, including mitochondrial disorders, neurodegenerative disorders and cancer, and during ageing is critically discussed.About:
This article is published in FEBS Letters.The article was published on 2021-04-01 and is currently open access. It has received 169 citations till now. The article focuses on the topics: Mitochondrial disease & Mitochondrial DNA.read more
Citations
More filters
Double genetic disruption of lactate dehydrogenases A and B is required to ablate the
M. Zdralevic,Almut Brand,L. Di Ianni,Katja Dettmer,Jörg Reinders,Katrin Singer,K. Peter,Annette Schnell,Christina Bruss,Sonja-Maria Decking,Gudrun E. Koehl,B. Felipe-Abrio,Jérôme Durivault,Pascale Bayer,Marie Evangelista,Thomas O'Brien,Peter J. Oefner,Kerstin Renner,Jacques Pouysségur,Marina Kreutz +19 more
TL;DR: In this article, the LDHA/B-DKO genes were disrupted in two cancer cell lines (human colon adenocarcinoma and murine melanoma cells) to reveal that the metabolic shift to OXPHOS caused by LDHA and B genetic disruptions is responsible for the tumors' escape and growth.
Journal Article
Overexpression of Mitochondrial Transcription Factor A Ameliorates Mitochondrial Deficiencies and Cardiac Failure After Myocardial Infarction
MasakiIkeuchi,HidenoriMatsusaka,DongchonKang,ShoujiMatsushima,TomomiIde,ToruKubota,ToshiyukiFujiwara,NaotakaHamasaki,AkiraTakeshita,KenjiSunagawa,HiroyukiTsutsui +10 more
TL;DR: Whether TFAM could protect the heart from mtDNA deficiencies and attenuate left ventricular remodeling and failure after myocardial infarction (MI) created by ligating the left coronary artery is examined and could ameliorate the decrease in mtDNA copy number and mitochondrial complex enzyme activities in post-MI hearts.
Journal ArticleDOI
Overexpression of Mitochondrial Transcription Factor A Ameliorates Mitochondrial Deficiencies and Cardiac Failure
TL;DR: Overexpression of TFAM inhibited LV remodeling after myocardial infarction and may provide a novel therapeutic strategy of cardiac failure.
Journal ArticleDOI
Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations.
Caroline Trumpff,Jeremy Michelson,Claudia J. Lagranha,Veronica Taleon,Kalpita R Karan,Gabriel Sturm,Daniel Lindqvist,Johan Fernström,Dirk Moser,Brett A. Kaufman,Martin Picard,Martin Picard +11 more
TL;DR: A systematic review of the literature reveals that blood cf-mtDNA varies in response to common real-world stressors including psychopathology, acute psychological stress, and exercise.
References
More filters
Journal ArticleDOI
Sequence and organization of the human mitochondrial genome
Stephen Anderson,Alan T. Bankier,Bart Barrell,M.H.L. de Bruijn,Alan Coulson,J. Drouin,J. Drouin,Ian C. Eperon,Donald P. Nierlich,Donald P. Nierlich,Bruce A. Roe,Bruce A. Roe,Frederick Sanger,P. H. Schreier,Andrew J.H. Smith,Rodger Staden,Ian G. Young,Ian G. Young +17 more
TL;DR: The complete sequence of the 16,569-base pair human mitochondrial genome is presented and shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
Journal ArticleDOI
Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1
Zhidan Wu,Pere Puigserver,Ulf Andersson,Chen-Yu Zhang,Guillaume Adelmant,Vamsi K. Mootha,Amy E Troy,Saverio Cinti,Bradford B. Lowell,Richard C. Scarpulla,Bruce M. Spiegelman +10 more
TL;DR: PGC-1, a cold-inducible coactivator of nuclear receptors, stimulates mitochondrial biogenesis and respiration in muscle cells through an induction of uncoupling protein 2 (UCP-2) and through regulation of the nuclear respiratory factors (NRFs).
Journal ArticleDOI
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Joseph T. Rodgers,Carlos Lerin,Wilhelm Haas,Steven P. Gygi,Bruce M. Spiegelman,Pere Puigserver +5 more
TL;DR: It is shown that the Sir2 homologue, SIRT1 controls the gluconeogenic/glycolytic pathways in liver in response to fasting signals through the transcriptional coactivator PGC-1α, and this findings have strong implications for the basic pathways of energy homeostasis, diabetes and lifespan.