Journal ArticleDOI
Modulation of cell death in the tumor microenvironment.
Bradly G. Wouters,Marianne Koritzinsky,Roland K. Chiu,Jan Theys,Jeroen Buijsen,Philippe Lambin +5 more
TLDR
It is suggested that stable microregions of hypoxia may play a positive role in tumor growth and that targeting the biological responses to Hypoxia and the pathways leading toHypoxia tolerance may also be attractive therapeutic strategies.About:
This article is published in Seminars in Radiation Oncology.The article was published on 2003-01-01. It has received 67 citations till now. The article focuses on the topics: HIF1A & Hypoxia (medical).read more
Citations
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Journal ArticleDOI
Activating transcription factor 4 is translationally regulated by hypoxic stress.
Jaime D. Blais,Vasilisa Filipenko,Meixia Bi,Heather P. Harding,David Ron,Costas Koumenis,Bradly G. Wouters,John C. Bell +7 more
TL;DR: It is shown that a subset of transcripts are preferentially translated during hypoxia, including activating transcription factor 4 (ATF4), an important mediator of the unfolded protein response, and an important integrated response between ER signaling and the cellular adaptation to hypoxic stress.
Journal ArticleDOI
Molecular basis of angiogenesis and cancer.
TL;DR: The molecular basis of angiogenesis during tumor growth is discussed and some of the molecules that are involved in this angiogenic switch are illustrated.
Journal ArticleDOI
Nanodrug delivery in reversing multidrug resistance in cancer cells.
TL;DR: Current review highlights various nanodrug delivery systems to overcome mechanism of MDR by neutralizing, evading, or exploiting the drug efflux pumps and those independent ofdrug efflux pump mechanism by silencing Bcl-2 and HIF1α gene expressions by siRNA and miRNA, modulating ceramide levels and targeting NF-κB.
Journal ArticleDOI
Autocrine laminin-5 ligates α6β4 integrin and activates RAC and NFκB to mediate anchorage-independent survival of mammary tumors
Nastaran Zahir,Johnathon N. Lakins,Alan J. Russell,Wen Yu Ming,Chandrima Chatterjee,Gabriela I. Rozenberg,M. Peter Marinkovich,Valerie M. Weaver +7 more
TL;DR: It is shown that autocrine LM-5 mediates anchorage-independent survival in breast tumors through ligation of a wild-type, but not a cytoplasmic tail–truncated α6β4 integrin, which is necessary for basal and epidermal growth factor–induced RAC activity and RAC mediates tumor survival.
Journal ArticleDOI
The tumor microenvironment in the post-PAGET era.
TL;DR: The conclusion is that the tumor microenvironment, by exerting regulatory functions and selective pressures drives cancer cells into one of several molecular evolution pathways thereby determining and shaping their malignancy phenotype.
References
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Journal ArticleDOI
Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
Journal ArticleDOI
Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation
Panu Jaakkola,David R. Mole,Ya-Min Tian,Michael I. Wilson,Janine Gielbert,Simon J. Gaskell,Alex von Kriegsheim,Holger F. Hebestreit,Mridul Mukherji,Christopher J. Schofield,Patrick H. Maxwell,Christopher W. Pugh,Peter J. Ratcliffe +12 more
TL;DR: It is shown that the interaction between human pVHL and a specific domain of the HIF-1α subunit is regulated through hydroxylation of a proline residue by an enzyme the authors have termed Hif-α prolyl-hydroxylase (HIF-PH).
Journal ArticleDOI
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Patrick H. Maxwell,Michael S. Wiesener,Gin-Wen Chang,Steven C. Clifford,Emma C. Vaux,Matthew Edward Cockman,Charles C. Wykoff,Christopher W. Pugh,Eamonn R. Maher,Peter J. Ratcliffe,Peter J. Ratcliffe +10 more
TL;DR: It is indicated that the interaction between HIF-1 and pVHL is iron dependent, and that it is necessary for the oxygen-dependent degradation of HIF α-subunits, which may underlie the angiogenic phenotype of VHL-associated tumours.
Journal ArticleDOI
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis.
TL;DR: It is shown that vascular endothelial growth factor (VEGF) probably functions as a hypoxia-inducible angiogenic factor and is specifically induced in a subset of glioblastoma cells distinguished by their immediate proximity to necrotic foci and the clustering of capillaries alongside VEGF-producing cells.
Journal ArticleDOI
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth.
Michael S. O'Reilly,Thomas Boehm,Yuen Shing,Naomi Fukai,George Vasios,William S. Lane,Evelyn Flynn,James R Birkhead,Bjorn R. Olsen,Judah Folkman +9 more
TL;DR: This work has identified endostatin, an angiogenesis inhibitor produced by hemangioendothelioma, a 20 kDa C-terminal fragment of collagen XVIII that specifically inhibits endothelial proliferation and potently inhibitsAngiogenesis and tumor growth.