Journal ArticleDOI
Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons
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TLDR
It is demonstrated that P0 is essential for the normal spiraling, compaction, and maintenance of the peripheral myelin sheath and the continued integrity of associated axons and suggested that this protein conveys a signal that regulates Schwann cell gene expression.About:
This article is published in Cell.The article was published on 1992-11-13. It has received 495 citations till now. The article focuses on the topics: Myelin protein zero & Schwann cell.read more
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Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
Corinna Lappe-Siefke,Sandra Goebbels,Michel Gravel,Eva Nicksch,John H.S. Lee,Peter E. Braun,Ian R. Griffiths,Klaus-Armin Nave +7 more
TL;DR: It is shown that Cnp1, which encodes 2′,3′-cyclic nucleotide phosphodiesterase in oligodendrocytes, is essential for axonal survival but not for myelin assembly, and the chief function of glia in supporting axonal integrity can thus be completely uncoupled from its function in maintaining compact myelin.
Journal ArticleDOI
Axonal swellings and degeneration in mice lacking the major proteolipid of myelin
Ian R. Griffiths,Matthias Klugmann,Matthias Klugmann,Matthias Klugmann,Thomas J. Anderson,Thomas J. Anderson,Thomas J. Anderson,Donald Yool,Donald Yool,Donald Yool,Christine E. Thomson,Christine E. Thomson,Christine E. Thomson,Markus H. Schwab,Markus H. Schwab,Markus H. Schwab,Armin Schneider,Armin Schneider,Armin Schneider,Frank Zimmermann,Frank Zimmermann,Frank Zimmermann,Mailise McCulloch,Mailise McCulloch,Mailise McCulloch,Nancy Nadon,Nancy Nadon,Nancy Nadon,Klaus-Armin Nave,Klaus-Armin Nave,Klaus-Armin Nave +30 more
TL;DR: Fiber degeneration could indicate that myelinated axons require local oligodendroglial support, and two myelin membrane proteolipids, PLP and DM20, were shown to be essential for the integrity of myelination.
Journal ArticleDOI
Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
TL;DR: A key role for Pax5 is defined in early B lymphopoiesis and midbrain patterning and all mutants failed to produce small pre-B, B, and plasma cells owing to a complete arrest of B cell development at an early precursor stage.
Journal ArticleDOI
Krox-20 controls myelination in the peripheral nervous system.
Piotr Topilko,Sylvie Schneider-Maunoury,Giovanni Levi,A. Baron-Van Evercooren,Amina Ben Younes Chennoufi,Tania Seitanidou,Charles Babinet,Patrick Charnay +7 more
TL;DR: It is demonstrated here that Krox-20 is also activated in Schwann cells before the onset of myelination and that its disruption blocks Schwann Cells at an early stage in their differentiation, thus preventing myelinations in the peripheral nervous system.
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Myelination of the nervous system: mechanisms and functions
Klaus-Armin Nave,Hauke B. Werner +1 more
TL;DR: Recent advances in the understanding of myelin biogenesis, its lifelong plasticity, and the reciprocal interactions of myelinating glia with the axons they ensheath are highlighted.
References
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Cadherin cell adhesion receptors as a morphogenetic regulator
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Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
TL;DR: It is demonstrated that src is not required for general cell viability (possibly because of functional overlap with other tyrosine kinases related to src) and an essential role for src in bone formation is uncovered.
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