mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells.
TLDR
It is suggested that mTORC1 may act as a "double edge sword" in the regulation of β cell mass and function in response to metabolic stress such as nutrient overload and insulin resistance.About:
This article is published in Cell Metabolism.The article was published on 2017-12-21 and is currently open access. It has received 126 citations till now. The article focuses on the topics: mTORC1 & PI3K/AKT/mTOR pathway.read more
Citations
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Journal Article
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. [Erratum: 2004 Sept. 23, v. 431, no. 7007, p. 485.]
Sung Hee Um,Francesca Frigerio,Mitsuhiro Watanabe,Frédéric Picard,Manel Joaquin,Melanie Sticker,Stefano Fumagalli,Peter R. Allegrini,Sara C. Kozma,Johan Auwerx +9 more
TL;DR: In this article, S6K1-deficient mice are protected against obesity owing to enhanced β-oxidation, but on a high fat diet, levels of glucose and free fatty acids still rise in S6k1-dependent mice, resulting in insulin receptor desensitization.
Journal ArticleDOI
Role of mTOR in Glucose and Lipid Metabolism
TL;DR: Recent findings on the role of mTOR in major metabolic organs, such as adipose tissues, liver, muscle, pancreas and brain are reviewed and their potentials as the mTOR related pharmacological targets are discussed.
Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
Dudley W. Lamming,Lan Ye,Pekka Katajisto,Marcus D. Goncalves,Maki Saitoh,Deanna Stevens,James G. Davis,Adam B. Salmon,Arlan Richardson,Rexford S. Ahima,David A. Guertin,David M. Sabatini,Joseph A. Baur +12 more
TL;DR: It is demonstrated that rapamycin disrupted a second mTOR complex, m TORC2, in vivo and that mTORC2 was required for the insulin-mediated suppression of hepatic gluconeogenesis and was sufficient to extend life span independently from changes in glucose homeostasis.
References
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mTOR Signaling in Growth Control and Disease
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.
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mTOR signaling in growth control and disease.
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
TL;DR: In this paper, the rictor-mTOR complex was used to identify compounds which modulate Akt activity mediated by the Rictor mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activation.
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.
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mTOR Signaling in Growth, Metabolism, and Disease.
TL;DR: Recent advances in understanding of mTOR function, regulation, and importance in mammalian physiology are reviewed and how the mTOR signaling network contributes to human disease is highlighted.