Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science.
Emily A. Holmes,Emily A. Holmes,Rory C. O'Connor,V. Hugh Perry,Irene Tracey,Simon Wessely,Louise Arseneault,Clive Ballard,Helen Christensen,Roxane Cohen Silver,Ian P. Everall,Tamsin Ford,Ann John,Thomas Kabir,Kate King,Ira Madan,Susan Michie,Andrew K. Przybylski,Roz Shafran,Angela Sweeney,Carol M. Worthman,Lucy Yardley,Katherine Cowan,Claire Cope,Matthew Hotopf,Edward T. Bullmore +25 more
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TLDR
There is an urgent need for research to address how mental health consequences for vulnerable groups can be mitigated under pandemic conditions, and on the impact of repeated media consumption and health messaging around COVID-19.About:
This article is published in The Lancet Psychiatry.The article was published on 2020-04-15 and is currently open access. It has received 3909 citations till now. The article focuses on the topics: Mental health & Psychological intervention.read more
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The mental health effects of the first two months of lockdown and social distancing during the Covid-19 pandemic in the UK
James Banks,Xiaowei Xu +1 more
TL;DR: Using longitudinal microdata for the UK over the period 2009-2020, this paper found that mental health in the UK worsened by 8.1% on average as a result of the pandemic and by much more for young adults and for women which are groups that already had lower levels of mental health before Covid19.
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Interventions to reduce social isolation and loneliness during COVID-19 physical distancing measures: A rapid systematic review.
Christopher Y.K. Williams,Adam T. Townson,Milan Kapur,Alice F. Ferreira,Rebecca Nunn,Julieta Galante,Julieta Galante,Veronica Phillips,Sarah Gentry,Juliet A. Usher-Smith +9 more
TL;DR: In this article, a rapid systematic review was conducted to identify effective interventions to reduce social isolation and loneliness that are compatible with COVID-19 shielding and social distancing measures, including psychological therapies such as mindfulness, lessons on friendship, robotic pets, and social facilitation software.
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Social Distancing Compliance under COVID-19 Pandemic and Mental Health Impacts: A Population-Based Study
TL;DR: Adoption, perceived effectiveness, and perceived compliance with social distancing were associated with lower stress levels and less anxiety and depressive symptoms, however, more days stayed-at-home wereassociated with more depressive symptoms.
Posted Content
The gender gap in mental well-being during the Covid-19 outbreak: Evidence from the UK
Ben Etheridge,Lisa Spantig +1 more
TL;DR: In this paper, the authors explored gender differences in: family and caring responsibilities; financial and work situation; social engagement; health situation, and health behaviours, including exercise, and found that women reported more close friends before the pandemic than men, and increased loneliness after its onset.
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Psychological impact of COVID-19 in the Swedish population: Depression, anxiety, and insomnia and their associations to risk and vulnerability factors.
TL;DR: The impacts of COVID-19 on mental health in Sweden are comparable to impacts shown in previous studies in Italy and China, and seem to impose most on the mental health of those already burdened with the impacts of mental health problems.
References
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Stress, appraisal, and coping
Richard S. Lazarus,Susan Folkman +1 more
TL;DR: In this paper, the authors present a detailed theory of psychological stress, building on the concepts of cognitive appraisal and coping, which have become major themes of theory and investigation in psychology.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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The psychological impact of quarantine and how to reduce it: rapid review of the evidence.
Samantha K Brooks,Rebecca K. Webster,Louise E. Smith,Lisa Woodland,Simon Wessely,Neil Greenberg,Gideon James Rubin +6 more
TL;DR: A review of the psychological impact of quarantine using three electronic databases is presented in this article, where the authors report negative psychological effects including post-traumatic stress symptoms, confusion, and anger.
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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.