Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science.
Emily A. Holmes,Emily A. Holmes,Rory C. O'Connor,V. Hugh Perry,Irene Tracey,Simon Wessely,Louise Arseneault,Clive Ballard,Helen Christensen,Roxane Cohen Silver,Ian P. Everall,Tamsin Ford,Ann John,Thomas Kabir,Kate King,Ira Madan,Susan Michie,Andrew K. Przybylski,Roz Shafran,Angela Sweeney,Carol M. Worthman,Lucy Yardley,Katherine Cowan,Claire Cope,Matthew Hotopf,Edward T. Bullmore +25 more
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TLDR
There is an urgent need for research to address how mental health consequences for vulnerable groups can be mitigated under pandemic conditions, and on the impact of repeated media consumption and health messaging around COVID-19.About:
This article is published in The Lancet Psychiatry.The article was published on 2020-04-15 and is currently open access. It has received 3909 citations till now. The article focuses on the topics: Mental health & Psychological intervention.read more
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How has COVID-19 lockdown impacted smoking? A thematic analysis of written accounts from UK smokers.
TL;DR: Results demonstrate a need for credible public health messaging on COVID-19 risk aimed at smokers, and implications for supporting smoking cessation are discussed, including maintaining quitting in those “social smokers” who quit during lockdown.
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Challenges facing essential workers: a cross-sectional survey of the subjective mental health and well-being of New Zealand healthcare and 'other' essential workers during the COVID-19 lockdown.
Caroline Bell,Jonathan Williman,Ben Beaglehole,James Stanley,Matthew Jenkins,Philip Gendall,Charlene Rapsey,Susanna Every-Palmer +7 more
TL;DR: In this article, the authors compared psychological outcomes, experiences and sources of stress over the COVID-19 lockdown in New Zealand in essential workers (healthcare and 'other' essential workers) with that of workers in non-essential work roles.
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Factors mediating the psychological well-being of healthcare workers responding to global pandemics: A systematic review.
TL;DR: This article reviewed mediators of psychological well-being among healthcare workers responding to pandemics and highlighted the prevalence of poor mental health in healthcare workers and proposed target mediators for future interventions.
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Distress and risk perception in people living with multiple sclerosis during the early phase of the COVID-19 pandemic.
TL;DR: Even during COVID-19, distress and risk perception are primarily driven by psychological factors, experiencing symptoms consistent with CO VID-19 and age, with minimal contribution from individual differences in health status, providing an impetus for continued efforts to optimize psychological interventions for people living with MS.
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Developing thinking around mental health science: the example of intrusive, emotional mental imagery after psychological trauma.
TL;DR: Three possible approaches through which mental health science may stimulate thinking around psychological treatment innovation are illustrated, focusing on single/specific target symptoms rather than full, multifaceted psychiatric diagnoses and investigating mechanisms that can be modified in treatment.
References
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Stress, appraisal, and coping
Richard S. Lazarus,Susan Folkman +1 more
TL;DR: In this paper, the authors present a detailed theory of psychological stress, building on the concepts of cognitive appraisal and coping, which have become major themes of theory and investigation in psychology.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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The psychological impact of quarantine and how to reduce it: rapid review of the evidence.
Samantha K Brooks,Rebecca K. Webster,Louise E. Smith,Lisa Woodland,Simon Wessely,Neil Greenberg,Gideon James Rubin +6 more
TL;DR: A review of the psychological impact of quarantine using three electronic databases is presented in this article, where the authors report negative psychological effects including post-traumatic stress symptoms, confusion, and anger.
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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.