Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science.
Emily A. Holmes,Emily A. Holmes,Rory C. O'Connor,V. Hugh Perry,Irene Tracey,Simon Wessely,Louise Arseneault,Clive Ballard,Helen Christensen,Roxane Cohen Silver,Ian P. Everall,Tamsin Ford,Ann John,Thomas Kabir,Kate King,Ira Madan,Susan Michie,Andrew K. Przybylski,Roz Shafran,Angela Sweeney,Carol M. Worthman,Lucy Yardley,Katherine Cowan,Claire Cope,Matthew Hotopf,Edward T. Bullmore +25 more
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TLDR
There is an urgent need for research to address how mental health consequences for vulnerable groups can be mitigated under pandemic conditions, and on the impact of repeated media consumption and health messaging around COVID-19.About:
This article is published in The Lancet Psychiatry.The article was published on 2020-04-15 and is currently open access. It has received 3909 citations till now. The article focuses on the topics: Mental health & Psychological intervention.read more
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Changes in social connection during COVID-19 social distancing: It's not (household) size that matters, it's who you're with.
TL;DR: In this article, the authors examined whether changes in overall feelings of social connection varied by household size and composition and found that living with a partner robustly and uniquely buffered shifts in social connection during the first phases of the pandemic.
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Climate change, environment pollution, COVID-19 pandemic and mental health.
Donatella Marazziti,Paolo Cianconi,Federico Mucci,Lara Foresi,Ilaria Chiarantini,Alessandra Della Vecchia +5 more
TL;DR: In this article, the authors reviewed the available scientific literature on these variables in order to suggest and comment on their eventual synergistic effects on mental health, with disturbances ranging from mild negative emotional responses to fullblown psychiatric conditions, specifically, anxiety and depression, stress/trauma-related disorders, and substance abuse.
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Prevalence of Perceived Stress, Anxiety, Depression, and Obsessive-Compulsive Symptoms in Health Care Workers and Other Workers in Alberta During the COVID-19 Pandemic: Cross-Sectional Survey.
Kelly Mrklas,Reham Shalaby,Marianne Hrabok,April Gusnowski,Wesley Vuong,Shireen Surood,Liana Urichuk,Daniel Li,Xin-Min Li,Andrew J. Greenshaw,Vincent I. O. Agyapong +10 more
TL;DR: The findings underscore the importance of anticipating and mitigating the mental health effects of pandemics using integrated implementation strategies and demonstrate the ease of safely and rapidly assessing mental health needs using an SMS text messaging platform during a pandemic.
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Perceived Social Support Protects Lonely People Against COVID-19 Anxiety: A Three-Wave Longitudinal Study in China.
Jianjie Xu,Jingyi Ou,Shuyi Luo,Zhuojun Wang,Edward C. Chang,Claire J. Novak,Jingyi Shen,Shaoying Zheng,Yinan Wang +8 more
TL;DR: Initial evidence is provided that perceived social support provides protection for lonely people in daily life as well as during unexpected disasters, which will contribute to finding ways to alleviate lonely people’s anxiety during this global health crisis.
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Coping Mechanisms: Exploring Strategies Utilized by Japanese Healthcare Workers to Reduce Stress and Improve Mental Health during the COVID-19 Pandemic.
TL;DR: In this article, the authors analyzed risk factors and coping mechanisms that could reduce the risk of poor mental health among healthcare workers during the COVID-19 pandemic in Japan and found that female gender, lower levels of communication with friends, and high anxiety were associated with poorer mental health.
References
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Stress, appraisal, and coping
Richard S. Lazarus,Susan Folkman +1 more
TL;DR: In this paper, the authors present a detailed theory of psychological stress, building on the concepts of cognitive appraisal and coping, which have become major themes of theory and investigation in psychology.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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The psychological impact of quarantine and how to reduce it: rapid review of the evidence.
Samantha K Brooks,Rebecca K. Webster,Louise E. Smith,Lisa Woodland,Simon Wessely,Neil Greenberg,Gideon James Rubin +6 more
TL;DR: A review of the psychological impact of quarantine using three electronic databases is presented in this article, where the authors report negative psychological effects including post-traumatic stress symptoms, confusion, and anger.
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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.