Multidomain Lifestyle Interventions for the Prevention of Cognitive Decline After Ischemic Stroke Randomized Trial
Karl Matz,Yvonne Teuschl,Bernadette Firlinger,Alexandra Dachenhausen,Magdalena Keindl,Leonhard Seyfang,Jaakko Tuomilehto,Michael Brainin,Peter Schnider,Christian Bancher,Michaela M. Pinter,Berthold Kepplinger,Susanne Asenbaum-Nan,Stefan Oberndorfer,Wolf-Dieter Heiss +14 more
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TLDR
This trial found no benefit of 24-month multidomain intervention with focus on improvement in lifestyle and vascular risk factors on the incidence of poststroke cognitive decline in comparison with standard stroke care.Abstract:
Background and Purpose—Cognitive impairment occurs in ≤30% of all stroke survivors. However, effective therapies aimed at preventing poststroke cognitive decline are lacking. We assessed the efficacy of a multidomain intervention on preventing cognitive decline after stroke. Methods—In this randomized, observer-blind trial patients were recruited within 3 months after an acute stroke in 5 Austrian neurological centers. Patients were assigned to a 24-month lifestyle-based multidomain intervention or standard stroke care. Primary outcomes were the cognitive subscale of the Alzheimer Disease Assessment Scale (ADAS-cog) and occurrence of cognitive decline in the composite scores of at least 2 of 5 cognitive domains at 24 months. Results—A total of 101 patients were randomized into multi-intervention and 101 into standard care during June 2010 and November 2012. Of them, 76 patients in the intervention group and 83 in the control group were included in the final intention-to-treat analysis. At 24 months, 8 of ...read more
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Journal ArticleDOI
Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease.
TL;DR: In this article, a review of the current knowledge of lifestyle-related risk factors and results from novel trials aiming to prevent cognitive decline and dementia is presented, including the World Wide FINGERS network, which aims to harmonize studies on dementia prevention, generate high-quality scientific evidence and promote its implementation.
Journal ArticleDOI
Post-stroke dementia - a comprehensive review
Milija Mijajlovic,Aleksandra M. Pavlović,Michael Brainin,Wolf-Dieter Heiss,Terence J. Quinn,Hege Ihle-Hansen,Dirk M. Hermann,Einor Ben Assayag,Edo Richard,Alexander Thiel,Efrat Kliper,Yong Il Shin,Yun Hee Kim,Seong Hye Choi,San Jung,Yeong Bae Lee,Osman Sinanović,Deborah Levine,Ilana Schlesinger,Ilana Schlesinger,Gillian Mead,Vuk Milošević,Didier Leys,Guri Hagberg,Marie Helene Ursin,Yvonne Teuschl,S. V. Prokopenko,Elena Mozheyko,Anna Bezdenezhnykh,Karl Matz,Vuk Aleksić,Dafin F. Muresanu,Amos D. Korczyn,Natan M. Bornstein +33 more
TL;DR: PSD is proposed as a label for any dementia following stroke in temporal relation and no specific biomarkers have been proven to robustly discriminate vulnerable patients (‘at risk brains’) from those with better prognosis or to discriminate Alzheimer’s disease dementia from PSD.
Journal ArticleDOI
Vascular Cognitive Impairment
Martin Dichgans,Didier Leys +1 more
TL;DR: New findings provide an opportunity for the present reappraisal of vascular cognitive impairment, and briefly address current therapeutic concepts.
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Vascular cognitive impairment.
Wiesje M. van der Flier,Ingmar Skoog,Julie A. Schneider,Leonardo Pantoni,Vincent Mok,Christopher Chen,Philip Scheltens +6 more
TL;DR: The term vascular cognitive impairment (VCI) was introduced around the start of the new millennium and refers to the contribution of vascular pathology to any severity of cognitive impairment, ranging from subjective cognitive decline and mild cognitive impairment to dementia as mentioned in this paper.
Journal ArticleDOI
Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study
TL;DR: 5-year risk of dementia was associated with age, event severity, previous stroke, dysphasia, baseline cognition, low education, pre-morbid dependency, leucoaraiosis, and diabetes, while incidence and prevalence of dementia in the population was compared with published UK population age-matched and sex-matched rates.
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