Journal ArticleDOI
Multifaceted role of cancer educated platelets in survival of cancer cells.
Reads0
Chats0
TLDR
In this article, the Tumor cell induced platelet aggregation (TCIPA) was proposed to assist in establishing a niche for the primary tumor at secondary site while recruiting granulocytes and monocytes.About:
This article is published in Thrombosis Research.The article was published on 2019-02-26. It has received 30 citations till now. The article focuses on the topics: Primary tumor & Metastasis.read more
Citations
More filters
Journal Article
Immobilized platelets support human colon carcinoma cell tethering, rolling and firm adhesion under dynamic flow conditions
TL;DR: Analysis of the ability of 3 human colon carcinoma cell lines to bind to surface-anchored platelets under flow and to identify the receptors involved in these processes suggests that platelets primarily recruit LS174T cells through a 2-step, sequential process of adhesive interactions that is distinct from that elaborated for neutrophils.
Journal ArticleDOI
Platelets and tumor-associated RNA transfer.
TL;DR: In this article, the potential use of platelet RNA biomarkers as a liquid biopsy biosource and methods to evaluate the transcriptomic content of platelets were discussed, as well as the potential to detect cancer and treatment monitoring.
Journal ArticleDOI
Delivery of platelet TPM3 mRNA into breast cancer cells via microvesicles enhances metastasis
TL;DR: It is reported that platelet TPM3 mRNA is delivered into BC cells through microvesicles and leads to enhanced migrative phenotype of BC cells and thus platelet‐derived T PM3 mRNA may be a suitable biomarker for early diagnosis of metastatic BC.
Journal ArticleDOI
Tumor-educated platelet as liquid biopsy in lung cancer patients.
TL;DR: T tumor-educated platelet has the potential to be used as liquid biopsy for a variety of clinical and investigational applications and offers opportunities to detect resistance mechanisms at an early stage.
Journal ArticleDOI
Platelet-mediated tumor metastasis mechanism and the role of cell adhesion molecules.
TL;DR: In this paper, the authors introduce the mechanism of platelet-related tumor metastasis and particularly focus on the role of cell adhesion molecules (CAMs) in it.
References
More filters
Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
TL;DR: It is shown that exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location, and it is proposed that this RNA is called “exosomal shuttle RNA” (esRNA).
Journal ArticleDOI
Epithelial–mesenchymal transitions in tumour progression
TL;DR: Epithelial–mesenchymal transition provides a new basis for understanding the progression of carcinoma towards dedifferentiated and more malignant states.
Journal ArticleDOI
How Matrix Metalloproteinases Regulate Cell Behavior
Mark D. Sternlicht,Zena Werb +1 more
TL;DR: Recent advances shed light on how the structure and function of the MMPs are related and on how their transcription, secretion, activation, inhibition, localization, and clearance are controlled.
Journal ArticleDOI
Microenvironmental regulation of metastasis
TL;DR: Experimental data demonstrating the role of the microenvironment in metastasis is described, areas for future research are identified and possible new therapeutic avenues are suggested.