Myeloid derived suppressor cells in human diseases
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TLDR
A comprehensive summary of the recent literature on human MDSC is provided, which shows that immune suppressor activity has been associated with high arginase 1 and iNOS activity as well as ROS production by M DSC.About:
This article is published in International Immunopharmacology.The article was published on 2011-07-01 and is currently open access. It has received 398 citations till now. The article focuses on the topics: Myeloid-derived Suppressor Cell & Population.read more
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Coordinated regulation of myeloid cells by tumours
TL;DR: This work considers myeloid cells as an intricately connected, complex, single system and focuses on how tumours manipulate the myeloids system to evade the host immune response.
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History of myeloid-derived suppressor cells
TL;DR: The history of M DSCs, their influence on tumour progression and metastasis, and the crosstalk between tumour cells, MDSCs and the host macroenvironment are discussed.
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Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells
TL;DR: Evidence is provided for an immunosuppressive role of tumor-derived lactate in inhibiting innate immune response against developing tumors via regulation of MDSC and NK cell activity.
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Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab
Christiane Meyer,Laurène Cagnon,Carla Costa-Nunes,Petra Baumgaertner,Nicole Montandon,Loredana Leyvraz,Olivier Michielin,Emanuela Romano,Daniel E. Speiser +8 more
TL;DR: Interestingly, clinical responders to ipilimumab therapy showed significantly less lin− CD14+ HLA-DR− cells as compared to non-responders, suggesting that the frequency of monocytic MDSC may be used as predictive marker of response, as low frequencies identify patients more likely benefitting from ipilitationab treatment.
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Clinical significance of macrophage heterogeneity in human malignant tumors
TL;DR: The role of TAMs in human malignant tumors and the cell–cell interactions between TAMs and tumor cells are discussed.
References
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Myeloid-derived suppressor cells as regulators of the immune system.
TL;DR: The origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit are discussed.
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Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer.
Bond Almand,Joseph I. Clark,Ekaterina Yu. Nikitina,James van Beynen,Nicholas R. English,Stella C. Knight,David P. Carbone,Dmitry I. Gabrilovich +7 more
TL;DR: In this paper, the authors investigated the nature and functional role of immature macrophages and dendritic cells (ImC) in cancer patients and determined that the population of ImC is composed of a small percentage (<2%) of hemopoietic progenitor cells.
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Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy
C. Marcela Diaz-Montero,Mohamed L. Salem,Michael I. Nishimura,Elizabeth Garrett-Mayer,David J. Cole,Alberto J. Montero +5 more
TL;DR: Testing the hypothesis that circulating MDSC levels correlate with clinical cancer stage, CTX-based chemotherapy, and metastatic tumor burden found that this information must be incorporated into the design of future trials exploring immune-based therapeutic strategies.
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5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell–Dependent Antitumor Immunity
Julie Vincent,Grégoire Mignot,Fanny Chalmin,Sylvain Ladoire,Mélanie Bruchard,Angélique Chevriaux,François Martin,Lionel Apetoh,Cédric Rébé,François Ghiringhelli +9 more
TL;DR: Findings suggest that the antitumor effect of 5FU is mediated, at least in part, by its selective cytotoxic action on MDSC.
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Altered recognition of antigen is a mechanism of CD8 + T cell tolerance in cancer
Srinivas Nagaraj,Kapil Gupta,Vladimir Pisarev,Leo Kinarsky,Simon Sherman,Loveleen Kang,Donna L. Herber,Jonathan P. Schneck,Dmitry I. Gabrilovich +8 more
TL;DR: In vivo models show that MDSCs directly disrupt the binding of specific peptide–major histocompatibility complex dimers to CD8-expressing T cells through nitration of tyrosines in a T-cell receptor (TCR)-CD8 complex, identifying a previously unknown mechanism of T- cell tolerance in cancer.