Nanostructured Hydrogels by Blend Electrospinning of Polycaprolactone/Gelatin Nanofibers.
Lode Daelemans,Iline Steyaert,Iline Steyaert,Ella Schoolaert,Camille Goudenhooft,Hubert Rahier,Karen De Clerck +6 more
TLDR
Cold-gelling experiments on these novel membranes show the possibility of obtaining water-stable PCL/Gt nanofibrous membranes, as well as nanostructured hydrogels reinforced with nan ofibers.Abstract:
Nanofibrous membranes based on polycaprolactone (PCL) have a large potential for use in biomedical applications but are limited by the hydrophobicity of PCL. Blend electrospinning of PCL with other biomedical suited materials, such as gelatin (Gt) allows for the design of better and new materials. This study investigates the possibility of blend electrospinning PCL/Gt nanofibrous membranes which can be used to design a range of novel materials better suited for biomedical applications. The electrospinnability and stability of PCL/Gt blend nanofibers from a non-toxic acid solvent system are investigated. The solvent system developed in this work allows good electrospinnable emulsions for the whole PCL/Gt composition range. Uniform bead-free nanofibers can easily be produced, and the resulting fiber diameter can be tuned by altering the total polymer concentration. Addition of small amounts of water stabilizes the electrospinning emulsions, allowing the electrospinning of large and homogeneous nanofibrous structures over a prolonged period. The resulting blend nanofibrous membranes are analyzed for their composition, morphology, and homogeneity. Cold-gelling experiments on these novel membranes show the possibility of obtaining water-stable PCL/Gt nanofibrous membranes, as well as nanostructured hydrogels reinforced with nanofibers. Both material classes provide a high potential for designing new material applications.read more
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Introduction To Polymers
TL;DR: The introduction to polymers is universally compatible with any devices to read and is available in the digital library an online access to it is set as public so you can get it instantly.
Journal ArticleDOI
Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review
Mokgaotsa Jonas Mochane,T.S. Motsoeneng,Emmanuel Rotimi Sadiku,Teboho Clement Mokhena,Jeremia Shale Sefadi +4 more
TL;DR: In this paper, a review of different methods for the electrospinning of polycaprolactone (PCL) and its composites for advanced applications is presented, and the steady state conditions as well as the effect of the electro-spinning parameters on the resultant morphology of electrospun fiber are also reported.
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The Relationships between Process Parameters and Polymeric Nanofibers Fabricated Using a Modified Coaxial Electrospinning.
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Low-cost hydrogel adsorbent enhanced by trihydroxy melamine and β-cyclodextrin for the removal of Pb(II) and Ni(II) in water
TL;DR: In this article, PVA hydrogel was crosslinked via trihydroxy melamine and epichlorohydrin, and β-cyclodextrin with strong adsorption capacity was added to remove the heavy metal ions.
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Plasma-Coated Polycaprolactone Nanofibers with Covalently Bonded Platelet-Rich Plasma Enhance Adhesion and Growth of Human Fibroblasts
Svetlana M. Miroshnichenko,Valeriia Timofeeva,Elizaveta Permykova,Sergey Ershov,Philip Kiryukhantsev-Korneev,Eva Dvořáková,Dmitry V. Shtansky,Lenka Zajíčková,Anastasiya O. Solovieva,Anton Manakhov +9 more
TL;DR: The reported research findings reveal the potential of PCL matrices for application in tissue engineering, while the plasma modification with COOH groups and their subsequent covalent binding with proteins expand this potential even further.
References
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