Journal ArticleDOI
Natural biflavonoids as potential therapeutic agents against microbial diseases.
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TLDR
A review of natural biflavonoids can be found in this paper, where the authors discuss their sources, reported mechanism of action, pharmacological uses, and comment on resistance mechanism, flavopiridol repurposing and the bioavailability aspects to provide a starting point for anti-microbial research in this area.About:
This article is published in Science of The Total Environment.The article was published on 2021-01-16. It has received 19 citations till now. The article focuses on the topics: Biflavonoids.read more
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Evaluation of apigenin-based biflavonoid derivatives as potential therapeutic agents against viral protease (3CLpro) of SARS-CoV-2 via molecular docking, molecular dynamics and quantum mechanics studies
TL;DR: Overall findings indicate that the apigenin-based biflavonoids may inhibit COVID-19 by significant interactions in the binding pocket and those results can pave the way in drug discovery although the effectiveness of these bioactive compounds should be further validated by in-vitro and in- vivo investigations.
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Hinokiflavone induces apoptosis, cell cycle arrest and autophagy in chronic myeloid leukemia cells through MAPK/NF-κB signaling pathway
TL;DR: In this article , the authors investigated the antitumor effect and possible mechanisms of Hinokiflavone (HF) in CML cells, and showed that HF significantly inhibited the viability of K562 cells in a concentration and time-dependent manner and induced G2/M phase arrest by up-regulating p21 and down-regulated Cdc2 protein.
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Current understanding of phytochemicals from Chinese herbal medicines for ferroptosis-mediated cancer prevention and treatment
TL;DR: In this paper , the authors summarized the current understanding of phytochemicals from Chinese herbal medicines in ferroptosis-mediated cancer prevention and treatment and the molecular mechanisms, which could be used clinically to enhance the effect of future phytochemical-inducing CHM therapies against cancers.
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Semysinthetic biflavonoid Morelloflavone-7,4',7″,3‴,4‴-penta-O-butanoyl is a more potent inhibitor of Proprotein Convertases Subtilisin/Kexin PC1/3 than Kex2 and Furin.
Aline Aparecida de Souza,Débora Martins de Andrade,Fábio da Silva Siqueira,Juliana F. Di Iorio,Marcia Paranho Veloso,Camila de Morais Coelho,Cláudio Viegas Junior,Vanessa Silva Gontijo,Marcelo Henrique dos Santos,Maria Cecília Zorél Meneghetti,Helena B. Nader,Ivarne L.S. Tersariol,Luiz Juliano,Maria A. Juliano,Wagner Alves de Souza Judice +14 more
TL;DR: Morelloflavone (BF1) and semisynthetic biflavonoid (BF2, 3 and 4) from Garcinia brasiliensis were tested as inhibitor of PC Kex2, PC1/3 and Furin, and determined IC50, Ki, human proinflammatory cytokines secretion in Caco-2 cells, mechanism of inhibition, and performed molecular docking studies as discussed by the authors.
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Metabolite Profiling of External and Internal Petals in Three Different Colors of Tea Flowers (Camellia sinensis) Using Widely Targeted Metabolomics
TL;DR: In this article , the secondary metabolites in the internal and external petals of white, white and pink, and pink tea flowers were studied using a widely targeted metabolomics method with ultra-high liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).
References
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Natural Products as Sources of New Drugs from 1981 to 2014
David J. Newman,Gordon M. Cragg +1 more
TL;DR: This contribution is a completely updated and expanded version of the four prior analogous reviews that were published in this journal in 1997, 2003, 2007, and 2012, and the time frame has been extended to cover the 34 years from January 1, 1981, to December 31, 2014, for all diseases worldwide, and from 1950 (earliest so far identified) to December 2014 for all approved antitumor drugs worldwide.
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The Therapeutic Potential of Apigenin.
Bahare Salehi,Alessandro Venditti,Mehdi Sharifi-Rad,Dorota Kregiel,Javad Sharifi-Rad,Alessandra Durazzo,Massimo Lucarini,Antonello Santini,Eliana B. Souto,Ettore Novellino,Hubert Antolak,Elena Azzini,William N. Setzer,Natália Martins +13 more
TL;DR: This work is an updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions and, in particular, results of in vivo research, and an introduction to its chemistry.
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Comprehensive review of antimicrobial activities of plant flavonoids
TL;DR: The development and application of flavonoid-based drugs could be a promising approach for antibiotic-resistant infections and improve understanding of the biological and molecular roles of plant flavonoids, focusing mostly on their antimicrobial activities.
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Antiviral Natural Products and Herbal Medicines
TL;DR: In this mini-review, a summary of the antiviral effects reported for several natural products and herbal medicines is summarized.
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Flavones: Food Sources, Bioavailability, Metabolism, and Bioactivity
TL;DR: The major sources of flavones and their concentrations in food and beverages are reviewed, comparing differences between species and the effects of glycosylation on bioavailability.