Journal ArticleDOI
Natural biflavonoids as potential therapeutic agents against microbial diseases.
Reads0
Chats0
TLDR
A review of natural biflavonoids can be found in this paper, where the authors discuss their sources, reported mechanism of action, pharmacological uses, and comment on resistance mechanism, flavopiridol repurposing and the bioavailability aspects to provide a starting point for anti-microbial research in this area.About:
This article is published in Science of The Total Environment.The article was published on 2021-01-16. It has received 19 citations till now. The article focuses on the topics: Biflavonoids.read more
Citations
More filters
Journal ArticleDOI
The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19
TL;DR: All information and knowledge presented here are very helpful for understanding the structural features and inhibitory mechanisms of SARS‐CoV‐2 3CLpro inhibitors, which offers new insights or inspiration to medicinal chemists for designing and developing more efficacious 3CL Pro inhibitors as novel anti‐coronavirus agents.
Journal ArticleDOI
Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids.
Giuliana Donadio,Francesca Mensitieri,Valentina Santoro,Valentina Parisi,Maria Laura Bellone,Nunziatina De Tommasi,Viviana Izzo,Fabrizio Dal Piaz +7 more
TL;DR: In this article, the authors present an overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins, which demonstrate the great potential of these compounds in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance.
Journal ArticleDOI
Bioactivity of natural biflavonoids in metabolism-related disease and cancer therapies
José C. Menezes,Marc Diederich +1 more
TL;DR: In this article, the translational role of biflavones in cancer with respect to the inhibition of metabolism-related processes/pathways, enzymes, or proteins, such as STAT3/SHP-1/PTEN, kinesins, tissue kallikreins, aromatase, estrogen, protein modifiers, antioxidant, autophagy, and apoptosis induction mechanisms, are discussed.
Journal ArticleDOI
Metabolic Engineering of Microbial Cell Factories for Biosynthesis of Flavonoids: A Review.
TL;DR: In this article, the authors mainly reviewed the biosynthetic pathways of flavonoids and the development of microbial expression systems for the production of Flavonoids in order to provide a useful reference for further research on synthetic metabolic engineering of the plant secondary metabolites.
Journal ArticleDOI
Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesis.
Von Novi de Leon,Joe Anthony H. Manzano,Delfin Yñigo H. Pilapil,Rey Arturo T. Fernandez,James Kyle Anthony R. Ching,Mark Tristan J. Quimque,Mark Tristan J. Quimque,Jay Carl M. Agbay,Kin Israel Notarte,Allan Patrick G. Macabeo +9 more
TL;DR: In this article, the potential of anti-HIV reverse transcriptase (RT) phytochemicals as inhibitors of SARS-CoV-2 non-structural proteins (nsps) was explored.
References
More filters
Journal ArticleDOI
Roles of flavonoids against coronavirus infection.
TL;DR: Flavonoids and their derivative may represent target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections.
Journal ArticleDOI
Therapeutic potential of coumarins as antiviral agents.
TL;DR: This manuscript thoroughly reviews the design, discovery and structure–activity relationship studies of the coumarin analogues as antiviral agents focusing mainly on lead optimization and its development into clinical candidates.
Journal ArticleDOI
Structure–activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities
TL;DR: The SAR analysis of flavonoids on influenza virus NAs revealed that for good inhibitory effect, the 4'-OH, 7-OH, C4O, and C2C3 functionalities were essential, and the presence of a glycosylation group greatly reduced NA inhibition.
Journal ArticleDOI
Flavonoid interactions during digestion, absorption, distribution and metabolism: a sequential structure-activity/property relationship-based approach in the study of bioavailability and bioactivity
Gerard Bryan Gonzales,Guy Smagghe,Charlotte Grootaert,Moisés João Zotti,Katleen Raes,John Van Camp +5 more
TL;DR: This approach reveals specific bioactive properties of flavonoids in the gastrointestinal tract as well as various barriers for their bioavailability, and determines the effect of different structural characteristics on the overall bioavailability of Flavonoids.
Journal ArticleDOI
Plant Secondary Metabolism: Diversity, Function and its Evolution:
TL;DR: This review tries to explain the patchy occurrence of SM in plants, and evidence is provided that the genes that encode the biosynthesis of SM appear to have a much wider distribution than the actual secondary metabolite.