Journal ArticleDOI
Natural biflavonoids as potential therapeutic agents against microbial diseases.
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TLDR
A review of natural biflavonoids can be found in this paper, where the authors discuss their sources, reported mechanism of action, pharmacological uses, and comment on resistance mechanism, flavopiridol repurposing and the bioavailability aspects to provide a starting point for anti-microbial research in this area.About:
This article is published in Science of The Total Environment.The article was published on 2021-01-16. It has received 19 citations till now. The article focuses on the topics: Biflavonoids.read more
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The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19
TL;DR: All information and knowledge presented here are very helpful for understanding the structural features and inhibitory mechanisms of SARS‐CoV‐2 3CLpro inhibitors, which offers new insights or inspiration to medicinal chemists for designing and developing more efficacious 3CL Pro inhibitors as novel anti‐coronavirus agents.
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Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids.
Giuliana Donadio,Francesca Mensitieri,Valentina Santoro,Valentina Parisi,Maria Laura Bellone,Nunziatina De Tommasi,Viviana Izzo,Fabrizio Dal Piaz +7 more
TL;DR: In this article, the authors present an overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins, which demonstrate the great potential of these compounds in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance.
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Bioactivity of natural biflavonoids in metabolism-related disease and cancer therapies
José C. Menezes,Marc Diederich +1 more
TL;DR: In this article, the translational role of biflavones in cancer with respect to the inhibition of metabolism-related processes/pathways, enzymes, or proteins, such as STAT3/SHP-1/PTEN, kinesins, tissue kallikreins, aromatase, estrogen, protein modifiers, antioxidant, autophagy, and apoptosis induction mechanisms, are discussed.
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Metabolic Engineering of Microbial Cell Factories for Biosynthesis of Flavonoids: A Review.
TL;DR: In this article, the authors mainly reviewed the biosynthetic pathways of flavonoids and the development of microbial expression systems for the production of Flavonoids in order to provide a useful reference for further research on synthetic metabolic engineering of the plant secondary metabolites.
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Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesis.
Von Novi de Leon,Joe Anthony H. Manzano,Delfin Yñigo H. Pilapil,Rey Arturo T. Fernandez,James Kyle Anthony R. Ching,Mark Tristan J. Quimque,Mark Tristan J. Quimque,Jay Carl M. Agbay,Kin Israel Notarte,Allan Patrick G. Macabeo +9 more
TL;DR: In this article, the potential of anti-HIV reverse transcriptase (RT) phytochemicals as inhibitors of SARS-CoV-2 non-structural proteins (nsps) was explored.
References
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Make yourself at home: viral hijacking of the PI3K/Akt signaling pathway.
Nora Diehl,Heiner Schaal +1 more
TL;DR: This review focuses on a number of remarkable examples of viral strategies, which exploit the PI3K/Akt signaling pathway for effective viral replication.
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Therapeutic potential of flavonoids and their mechanism of action against microbial and viral infections—A review
TL;DR: Flavonoids act as bactericidal and bacteriostatic by damaging cytoplasmic membrane, inhibiting energy metabolism and inhibiting synthesis of nucleic acids against different microorganisms, so antiviral drugs are least available, since flavonoids possess antiviral properties.
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Influenza neuraminidase: A druggable target for natural products
Ulrike Grienke,Michaela Schmidtke,Susanne von Grafenstein,Johannes Kirchmair,Klaus R. Liedl,Judith M. Rollinger +5 more
TL;DR: This work addresses the latest developments in theoretical and experimental research on properties of NA that are and will be driving anti-influenza drug development now and in the near future.
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Natural products' role against COVID-19
Ananda da Silva Antonio,Larissa Silveira Moreira Wiedemann,Valdir Florêncio da Veiga-Junior,Valdir Florêncio da Veiga-Junior +3 more
TL;DR: Natural products can play an important role in COVID-19 chemotherapy development and should be considered as a raw material for further development.
Journal ArticleDOI
Coumarin: An emerging antiviral agent
TL;DR: The present state of understanding with a focus on coumarin's antiviral effect and their possible molecular mechanisms against Influenza virus, HIV, Hepatitis virus, Dengue virus and Chikungunya virus are summarized.