Journal ArticleDOI
Natural biflavonoids as potential therapeutic agents against microbial diseases.
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TLDR
A review of natural biflavonoids can be found in this paper, where the authors discuss their sources, reported mechanism of action, pharmacological uses, and comment on resistance mechanism, flavopiridol repurposing and the bioavailability aspects to provide a starting point for anti-microbial research in this area.About:
This article is published in Science of The Total Environment.The article was published on 2021-01-16. It has received 19 citations till now. The article focuses on the topics: Biflavonoids.read more
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The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19
TL;DR: All information and knowledge presented here are very helpful for understanding the structural features and inhibitory mechanisms of SARS‐CoV‐2 3CLpro inhibitors, which offers new insights or inspiration to medicinal chemists for designing and developing more efficacious 3CL Pro inhibitors as novel anti‐coronavirus agents.
Journal ArticleDOI
Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids.
Giuliana Donadio,Francesca Mensitieri,Valentina Santoro,Valentina Parisi,Maria Laura Bellone,Nunziatina De Tommasi,Viviana Izzo,Fabrizio Dal Piaz +7 more
TL;DR: In this article, the authors present an overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins, which demonstrate the great potential of these compounds in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance.
Journal ArticleDOI
Bioactivity of natural biflavonoids in metabolism-related disease and cancer therapies
José C. Menezes,Marc Diederich +1 more
TL;DR: In this article, the translational role of biflavones in cancer with respect to the inhibition of metabolism-related processes/pathways, enzymes, or proteins, such as STAT3/SHP-1/PTEN, kinesins, tissue kallikreins, aromatase, estrogen, protein modifiers, antioxidant, autophagy, and apoptosis induction mechanisms, are discussed.
Journal ArticleDOI
Metabolic Engineering of Microbial Cell Factories for Biosynthesis of Flavonoids: A Review.
TL;DR: In this article, the authors mainly reviewed the biosynthetic pathways of flavonoids and the development of microbial expression systems for the production of Flavonoids in order to provide a useful reference for further research on synthetic metabolic engineering of the plant secondary metabolites.
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Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesis.
Von Novi de Leon,Joe Anthony H. Manzano,Delfin Yñigo H. Pilapil,Rey Arturo T. Fernandez,James Kyle Anthony R. Ching,Mark Tristan J. Quimque,Mark Tristan J. Quimque,Jay Carl M. Agbay,Kin Israel Notarte,Allan Patrick G. Macabeo +9 more
TL;DR: In this article, the potential of anti-HIV reverse transcriptase (RT) phytochemicals as inhibitors of SARS-CoV-2 non-structural proteins (nsps) was explored.
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Translational role of natural coumarins and their derivatives as anticancer agents.
José C. Menezes,Marc Diederich +1 more
TL;DR: This review hopes to stimulate and offer medicinal chemists and the reader in general an outlook on natural coumarins and their derivatives with potential for cancer therapy.
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Synthesis of Biologically Relevant Biflavanoids – A Review
TL;DR: This review compiles these synthetic approaches utilizing coupling and rearrangement strategies into nine different methods including Ullmann coupling of halogenated flavones, biphenyl‐based construction of biflavanoids, metal‐catalyzed cross‐coupling of Flavones, Wessely–Moser rearrangements, oxidative coupling of flavones and dehydrogenation-based or hydrogenation‐based synthesis.
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Fatty Acid Synthesis as a Target for Antimalarial Drug Discovery
TL;DR: Rapid progress has been made, largely due to the vast body of mechanistic and structural information about type II FAS enzymes from bacteria and the availability of inhibitors and ongoing antimalarial drug discovery projects are described.
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Mechanism of action of the antiherpesvirus biflavone ginkgetin.
K Hayashi,T Hayashi,N Morita +2 more
TL;DR: Ginkgetin suppressed viral protein synthesis when added at various steps of HSV-1 replication and exerted strong inhibition of transcription of the immediate-early genes.
Journal ArticleDOI
Prospecting for Bioactive Constituents from Traditional Medicinal Plants through Ethnobotanical Approaches
Ronghui Gu,Yue-Hu Wang,Bo Long,Edward J. Kennelly,Shi-Biao Wu,Bo Liu,Ping Li,Chunlin Long,Chunlin Long +8 more
TL;DR: Modern ethnobotanical approaches to explore folk medicinal plants as candidates for drug discovery with the greatest possibility of success are discussed and determining the bioactive mechanisms and tracing structure-activity relationships will promote the discovery of new drugs and pharmacological agents.