Journal ArticleDOI
Natural biflavonoids as potential therapeutic agents against microbial diseases.
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TLDR
A review of natural biflavonoids can be found in this paper, where the authors discuss their sources, reported mechanism of action, pharmacological uses, and comment on resistance mechanism, flavopiridol repurposing and the bioavailability aspects to provide a starting point for anti-microbial research in this area.About:
This article is published in Science of The Total Environment.The article was published on 2021-01-16. It has received 19 citations till now. The article focuses on the topics: Biflavonoids.read more
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The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19
TL;DR: All information and knowledge presented here are very helpful for understanding the structural features and inhibitory mechanisms of SARS‐CoV‐2 3CLpro inhibitors, which offers new insights or inspiration to medicinal chemists for designing and developing more efficacious 3CL Pro inhibitors as novel anti‐coronavirus agents.
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Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids.
Giuliana Donadio,Francesca Mensitieri,Valentina Santoro,Valentina Parisi,Maria Laura Bellone,Nunziatina De Tommasi,Viviana Izzo,Fabrizio Dal Piaz +7 more
TL;DR: In this article, the authors present an overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins, which demonstrate the great potential of these compounds in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance.
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Bioactivity of natural biflavonoids in metabolism-related disease and cancer therapies
José C. Menezes,Marc Diederich +1 more
TL;DR: In this article, the translational role of biflavones in cancer with respect to the inhibition of metabolism-related processes/pathways, enzymes, or proteins, such as STAT3/SHP-1/PTEN, kinesins, tissue kallikreins, aromatase, estrogen, protein modifiers, antioxidant, autophagy, and apoptosis induction mechanisms, are discussed.
Journal ArticleDOI
Metabolic Engineering of Microbial Cell Factories for Biosynthesis of Flavonoids: A Review.
TL;DR: In this article, the authors mainly reviewed the biosynthetic pathways of flavonoids and the development of microbial expression systems for the production of Flavonoids in order to provide a useful reference for further research on synthetic metabolic engineering of the plant secondary metabolites.
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Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesis.
Von Novi de Leon,Joe Anthony H. Manzano,Delfin Yñigo H. Pilapil,Rey Arturo T. Fernandez,James Kyle Anthony R. Ching,Mark Tristan J. Quimque,Mark Tristan J. Quimque,Jay Carl M. Agbay,Kin Israel Notarte,Allan Patrick G. Macabeo +9 more
TL;DR: In this article, the potential of anti-HIV reverse transcriptase (RT) phytochemicals as inhibitors of SARS-CoV-2 non-structural proteins (nsps) was explored.
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Natural cinnamic acids, synthetic derivatives and hybrids with antimicrobial activity.
TL;DR: The literature data on the antimicrobial activity of the natural cinnamic acids and related derivatives is summarized to summarize the relative comparison between series of molecules and the derivation of structure-activity relationships.
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Flavonoid metabolism: the interaction of metabolites and gut microbiota
TL;DR: Several dietary flavonoids exhibit anti-oxidative, anti-inflammatory, and anti-osteoporotic activities relevant to prevention of chronic diseases, including lifestyle-related diseases.
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Influenza Virus Neuraminidase Structure and Functions.
Julie L. McAuley,Brad Gilbertson,Sanja Trifkovic,Sanja Trifkovic,Lorena E. Brown,Jennifer L. McKimm-Breschkin +5 more
TL;DR: The various structural features of NA are investigated, linking these with functional outcomes in viral replication and the contribution of evolving NA activity to viral attachment, entry and release of virions from infected cells, and maintenance of functional balance with the viral hemagglutinin are discussed.
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The Infectious Etiology of Alzheimer's Disease.
TL;DR: Emerging evidence supports the hypothesis of the role of neurotropic viruses from the Herpesviridae family, especially Human herpesvirus 1 (HHV-1), Cytomegalovirus (CMV), and Human herpesVirus 2 ( HHV-2), in AD neuropathology.
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Antibacterial Activity of Some Flavonoids and Organic Acids Widely Distributed in Plants.
TL;DR: These compounds were generally more active against Gram-negative bacteria: Escherichia coli and Pseudomonas aeruginosa than Gram-positive ones: Enterococcus faecalis and Staphylococcus aureus and the presence of hydroxyl groups in the phenyl rings A and B did not influence on the level of their activity.