Journal ArticleDOI
Natural biflavonoids as potential therapeutic agents against microbial diseases.
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TLDR
A review of natural biflavonoids can be found in this paper, where the authors discuss their sources, reported mechanism of action, pharmacological uses, and comment on resistance mechanism, flavopiridol repurposing and the bioavailability aspects to provide a starting point for anti-microbial research in this area.About:
This article is published in Science of The Total Environment.The article was published on 2021-01-16. It has received 19 citations till now. The article focuses on the topics: Biflavonoids.read more
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The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19
TL;DR: All information and knowledge presented here are very helpful for understanding the structural features and inhibitory mechanisms of SARS‐CoV‐2 3CLpro inhibitors, which offers new insights or inspiration to medicinal chemists for designing and developing more efficacious 3CL Pro inhibitors as novel anti‐coronavirus agents.
Journal ArticleDOI
Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids.
Giuliana Donadio,Francesca Mensitieri,Valentina Santoro,Valentina Parisi,Maria Laura Bellone,Nunziatina De Tommasi,Viviana Izzo,Fabrizio Dal Piaz +7 more
TL;DR: In this article, the authors present an overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins, which demonstrate the great potential of these compounds in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance.
Journal ArticleDOI
Bioactivity of natural biflavonoids in metabolism-related disease and cancer therapies
José C. Menezes,Marc Diederich +1 more
TL;DR: In this article, the translational role of biflavones in cancer with respect to the inhibition of metabolism-related processes/pathways, enzymes, or proteins, such as STAT3/SHP-1/PTEN, kinesins, tissue kallikreins, aromatase, estrogen, protein modifiers, antioxidant, autophagy, and apoptosis induction mechanisms, are discussed.
Journal ArticleDOI
Metabolic Engineering of Microbial Cell Factories for Biosynthesis of Flavonoids: A Review.
TL;DR: In this article, the authors mainly reviewed the biosynthetic pathways of flavonoids and the development of microbial expression systems for the production of Flavonoids in order to provide a useful reference for further research on synthetic metabolic engineering of the plant secondary metabolites.
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Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesis.
Von Novi de Leon,Joe Anthony H. Manzano,Delfin Yñigo H. Pilapil,Rey Arturo T. Fernandez,James Kyle Anthony R. Ching,Mark Tristan J. Quimque,Mark Tristan J. Quimque,Jay Carl M. Agbay,Kin Israel Notarte,Allan Patrick G. Macabeo +9 more
TL;DR: In this article, the potential of anti-HIV reverse transcriptase (RT) phytochemicals as inhibitors of SARS-CoV-2 non-structural proteins (nsps) was explored.
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Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition
Young Bae Ryu,Hyung Jae Jeong,Jang Hoon Kim,Young-Min Kim,Ji-Young Park,Doman Kim,Thi Thanh Hanh Naguyen,Su-Jin Park,Jong Sun Chang,Ki Hun Park,Mun Chual Rho,Woo Song Lee +11 more
TL;DR: More potent activity appeared to be associated with the presence of an apigenin moiety at position C-3′ of flavones, as biflavone had an effect on 3CLpro inhibitory activity.
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Flavones: An important scaffold for medicinal chemistry
TL;DR: The present review gives detail about the structural requirement of flavone derivatives for various pharmacological activities and may provide an opportunity to scientists of medicinal chemistry discipline to design selective, optimize as well as poly-functional flavones derivatives for the treatment of multi-factorial diseases.
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The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective.
TL;DR: This review traces the development of the field over the past 8 decades, and indicates the current state of the art, and how it was reached.
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Flavonoids: promising natural compounds against viral infections.
TL;DR: The evidence for antiviral activity of different flavonoids is summarized, highlighting, where investigated, the cellular and molecular mechanisms of action on viruses and future perspectives on therapeutic applications of flavonoid against viral infections are presented.
Journal ArticleDOI
In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora
Yuh-Meei Lin,Herbert M. Anderson,Michael T. Flavin,Yeah-Huei S. Pai,Eugenia Mata-Greenwood,Thitima Pengsuparp,John M. Pezzuto,Raymond F. Schinazi,Stephen H. Hughes,Fa-Ching Chen +9 more
TL;DR: The results indicated that compounds 3 and 4 demonstrated similar activity against HIV-1 reverse transcriptase (RT), with IC50 values of 65 microM and 170 microM, respectively.