Natural compounds for cancer treatment and prevention
Stefania Nobili,Donatella Lippi,Ewa Witort,Martino Donnini,L Bausi,Enrico Mini,Sergio Capaccioli +6 more
TLDR
The main natural compounds used in cancer therapy and prevention, the historical aspects of their application and pharmacognosy, and some critical aspects of current cancer chemotherapy are discussed, focusing on genetics and genomics.About:
This article is published in Pharmacological Research.The article was published on 2009-06-01 and is currently open access. It has received 623 citations till now. The article focuses on the topics: Cancer.read more
Citations
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Technologies for Extraction and Production of Bioactive Compounds to be Used as Nutraceuticals and Food Ingredients: An Overview
G. Joana Gil-Chavez,José A. Villa,J. Fernando Ayala-Zavala,J. Basilio Heredia,D.R. Sepulveda,Elhadi M. Yahia,Gustavo A. González-Aguilar +6 more
TL;DR: The most commonly used methods for their extraction are the conventional liquid-liquid or solid-liquid extraction and the advanced methods include pressurized liquid extraction, subcritical and supercritical extractions, and microwave-and ultrasound-assisted extractions.
Journal ArticleDOI
Natural products for cancer chemotherapy
Arnold L. Demain,Preeti Vaishnav +1 more
TL;DR: This review points out those technologies needed to produce the anti‐tumour compounds of the future, with fewer side‐effects and/or with greater therapeutic efficiency.
Journal ArticleDOI
Biomedical applications of nisin
Jae M. Shin,J.W. Gwak,Pachiyappan Kamarajan,J.C. Fenno,Alexander H. Rickard,Yvonne L. Kapila +5 more
TL;DR: Nisin has now been shown to have antimicrobial activity against both Gram‐positive and Gram‐negative disease‐associated pathogens and can work synergistically in combination with conventional therapeutic drugs.
Journal ArticleDOI
Dietary phytochemicals and their potential effects on obesity: a review.
TL;DR: The progresses made in understanding of obesity are summarized, including the role of inflammation process, the recently understood endocrine function of adipose tissue, as well as passive roles of processes of energy storage and adipogenesis related to fat cell lifecycle: differentiation, maturation, and apoptosis.
Journal ArticleDOI
Improving solubility and chemical stability of natural compounds for medicinal use by incorporation into liposomes.
Maria Coimbra,Benedetta Isacchi,Louis van Bloois,Javier Sastre Toraño,Aldo Ket,Xiaojie Wu,Femke Broere,Josbert M. Metselaar,Cristianne J.F. Rijcken,Gert Storm,Rita Bilia,Raymond M. Schiffelers +11 more
TL;DR: Despite the instability of liposome-association of 3-oxo-C(12)-homoserine lactone and resveratrol, intravenous administration of these compounds inhibited tumor growth for approximately 70% in a murine tumor model, showing that simple solubilization can have important therapeutic benefits.
References
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Journal ArticleDOI
Microtubules as a target for anticancer drugs.
Mary Ann Jordan,Leslie Wilson +1 more
TL;DR: Highly dynamic mitotic-spindle microtubules are among the most successful targets for anticancer therapy, and it is now known that at lower concentrations, microtubule-targeted drugs can suppress micro Tubule dynamics without changingmicrotubule mass; this action leads to mitotic block and apoptosis.
Journal ArticleDOI
Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.
Journal ArticleDOI
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial
Jean-Yves Douillard,David Cunningham,Arnaud Roth,M. Navarro,Roger D James,P. Karasek,P. Jandik,Timothy Iveson,Joseph C. Carmichael,M. Alakl,G. Gruia,Lucile Awad,Philippe Rougier +12 more
TL;DR: Irinotecan combined with fluorouracil and calcium folinate was well-tolerated and increased response rate, time to progression, and survival, with a later deterioration in quality of life.
Journal ArticleDOI
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
TL;DR: It is demonstrated that an oncogene, specifically the adenovirus E1A gene, can sensitize fibroblasts to apoptosis induced by ionizing radiation, 5-fluorouracil, etoposide, and adriamycin, and the involvement of p53 in the apoptotic response suggests a mechanism whereby tumor cells can acquire cross-resistance to anticancer agents.
Journal ArticleDOI
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
Susan P.C. Cole,Gabu Bhardwaj,James H. Gerlach,J. E. Mackie,Caroline E. Grant,Kurt C. Almquist,Alistair J. Stewart,Ebba U. Kurz,A. M. V. Duncan,Roger G. Deeley +9 more
TL;DR: Reversion to drug sensitivity was associated with loss of gene amplification and a marked decrease in mRNA expression, and the mRNA encodes a member of the ATP-binding cassette transmembrane transporter superfamily.
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