Journal ArticleDOI
Natural variation in a Drosophila clock gene and temperature compensation.
Lesley A. Sawyer,J. Michael Hennessy,J. Michael Hennessy,Alexandre A. Peixoto,Alexandre A. Peixoto,Ezio Rosato,Ezio Rosato,Helen Parkinson,Helen Parkinson,Rodolfo Costa,Rodolfo Costa,Charalambos P. Kyriacou,Charalambos P. Kyriacou +12 more
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TLDR
Thr-Gly length variation from both wild-caught and transgenic individuals is related to the flies' ability to maintain a circadian period at different temperatures and gives a rare glimpse of the interplay between molecular polymorphism, behavior, population biology, and natural selection.Abstract:
The threonine-glycine (Thr-Gly) encoding repeat within the clock gene period of Drosophila melanogaster is polymorphic in length. The two major variants (Thr-Gly)17 and (Thr-Gly)20 are distributed as a highly significant latitudinal cline in Europe and North Africa. Thr-Gly length variation from both wild-caught and transgenic individuals is related to the flies' ability to maintain a circadian period at different temperatures. This phenomenon provides a selective explanation for the geographical distribution of Thr-Gly lengths and gives a rare glimpse of the interplay between molecular polymorphism, behavior, population biology, and natural selection.read more
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Molecular Bases for Circadian Clocks
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Enhanced Emission and Its Switching in Fluorescent Organic Nanoparticles
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Time zones: a comparative genetics of circadian clocks.
Michael W. Young,Steve A. Kay +1 more
TL;DR: The circadian clock is a widespread cellular mechanism that underlies diverse rhythmic functions in organisms from bacteria and fungi, to plants and animals, and the weight of evidence favours their independent evolutionary origins in different kingdoms.
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Natural Variation in a Neuropeptide Y Receptor Homolog Modifies Social Behavior and Food Response in C. elegans
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Plant Circadian Rhythms
TL;DR: The earth rotates on its axis every 24 h, with the result that any position on the earth's surface alternately faces toward or away from the sun—day and night.
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Journal ArticleDOI
TEMPORAL ORGANIZATION: Reflections of a Darwinian Clock -Watcher
TL;DR: This essay was prompted by the Editor’s invitation to illustrate the excitement and adventure inherent in scientific work while reflecting on my own preoccupation, as an evolutionary biologist, with biological clocks.
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Circadian oscillation of a mammalian homologue of the Drosophila period gene.
Hajime Tei,Hitoshi Okamura,Yasufumi Shigeyoshi,Chiaki Fukuhara,Ritsuko Ozawa,Matsumi Hirose,Yoshiyuki Sakaki +6 more
TL;DR: The human and mouse genes (hPER and mPer, respectively) encoding PAS-domain (PAS, a dimerization domain present in Per, Amt and Sim)-containing polypeptides that are highly homologous to dPer are identified.
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RIGUI, a putative mammalian ortholog of the Drosophila period gene.
TL;DR: In this article, the authors have isolated a human gene termed RIGUI that encodes a bHLH/PAS protein 44% homologous to Drosophila period.
Journal ArticleDOI
On temperature independence in the clock system controlling emergence time in drosophila.
TL;DR: The authors' investigations are now directed toward the further elucidation of the nature of the active material, the duplication of the effect of the growing tumor in the living embryo with theActive material isolated from the tumors, and an examination of the metabolic response of the nerve cells under the influence of the growth-promoting agent.