Needle-free skin patch vaccination method for anthrax.
Gary R. Matyas,Arthur M. Friedlander,Gregory M. Glenn,Stephen F. Little,Jianmei Yu,Carl R. Alving +5 more
TLDR
Three immunizations of mice with recombinant protective antigen by transcutaneous immunization induced long-term neutralizing antibody titers that were superior to those obtained with aluminum-adsorbed rPA, and 100% protection was observed against lethal anthrax challenge.Abstract:
Three immunizations of mice with recombinant protective antigen (rPA) by transcutaneous immunization (TCI) induced long-term neutralizing antibody titers that were superior to those obtained with aluminum-adsorbed rPA. In addition, rPA alone exhibited adjuvant activity for TCI. Forty-six weeks after completion of TCI, 100% protection was observed against lethal anthrax challenge.read more
Citations
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Journal ArticleDOI
Vaccines: past, present and future.
TL;DR: The vaccines developed over the first two hundred years since Jenner's lifetime have accomplished striking reductions of infection and disease wherever applied, and Pasteur's early approaches to vaccine development, attenuation and inactivation are even now the two poles of vaccine technology.
Journal ArticleDOI
Binary Bacterial Toxins: Biochemistry, Biology, and Applications of Common Clostridium and Bacillus Proteins
TL;DR: This review comprehensively surveys the literature and discusses the similarities and distinct differences between each Clostridium and Bacillus binary toxin in terms of their biochemistry, biology, genetics, structure, and applications in science and medicine.
Journal ArticleDOI
Protective Immunization against Inhalational Anthrax: A Comparison of Minimally Invasive Delivery Platforms
John A. Mikszta,Vincent J. Sullivan,Cheryl H. Dean,Andrea M. Waterston,Jason B. Alarcon,John P. Dekker,John M. Brittingham,Juan Huang,C. Robin Hwang,Matthew S. Ferriter,Ge Jiang,Kevin D. Mar,Kamal U. Saikh,Bradley G. Stiles,Chad J. Roy,Robert G. Ulrich,Noel G. Harvey +16 more
TL;DR: It is demonstrated, for the first time, that cutaneous or nasal mucosal administration of rPA provides complete protection against inhalational anthrax in rabbits.
Journal ArticleDOI
Advances in transcutaneous vaccine delivery: do all ways lead to Rome?
TL;DR: The immune system of the skin is discussed, focusing on the role the different types of skin residing dendritic cells play in the immune response, and adjuvants and the large variety of devices developed to deliver vaccines into the skin are summarized.
Book ChapterDOI
Delivery systems for intradermal vaccination
TL;DR: The prospects for bringing ID vaccination into more widespread clinical practice are encouraging, given the large number of technologies for ID delivery under development.
References
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Journal ArticleDOI
Aluminum compounds as vaccine adjuvants
TL;DR: Limitations of aluminum adjuvants include local reactions, augmentation of IgE antibody responses, ineffectiveness for some antigens and inability to augment cell-mediated immune responses, especially cytotoxic T-cell responses.
Journal ArticleDOI
Transcutaneous immunization: a human vaccine delivery strategy using a patch.
Gregory M. Glenn,David N. Taylor,Xiuru Li,Sarah Schlesinger Frankel,Andrew D. Montemarano,Carl R. Alving +5 more
TL;DR: This work demonstrates safe application of a patch containing heat-labile enterotoxin (LT, derived from Escherichia coli) to humans, resulting in robust LT-antibody responses, and suggests that TCI may enhance efficacy as well as improve vaccine delivery.
Journal ArticleDOI
In vitro correlate of immunity in a rabbit model of inhalational anthrax.
Margaret L. Pitt,Stephen F. Little,Bruce E. Ivins,P.F. Fellows,J. Barth,John Hewetson,Paul H. Gibbs,Mark T. Dertzbaugh,Arthur M. Friedlander +8 more
TL;DR: A serological correlate of vaccine-induced immunity was identified in the rabbit model of inhalational anthrax and antibody levels to PA at both 6 and 10 weeks were significant predictors of survival.
Journal ArticleDOI
Search for correlates of protective immunity conferred by anthrax vaccine.
Shaul Reuveny,Moshe D. White,Yaakov Adar,Yaron Kafri,Zeev Altboum,Yehusha Gozes,David Kobiler,Avigdor Shafferman,Baruch Velan +8 more
TL;DR: Results clearly demonstrate that neutralizing antibodies to PA constitute a major component of the protective immunity against anthrax and suggest that this parameter could be used as a surrogate marker for protection.
Journal ArticleDOI
Efficacy of a human anthrax vaccine in guinea pigs, rabbits, and rhesus macaques against challenge by Bacillus anthracis isolates of diverse geographical origin
P.F. Fellows,M.K. Linscott,Bruce E. Ivins,Margaret L. Pitt,Cynthia A. Rossi,Paul H. Gibbs,Arthur M. Friedlander +6 more
TL;DR: It is demonstrated that, although AVA confers variable protection against different B. anthracis isolates in guinea pigs, it is highly protective against these same isolate in both rabbits and rhesus macaques.