Neural innervation of white adipose tissue and the control of lipolysis.
TLDR
Transsynaptic viral tract tracers revealed WAT central sympathetic and sensory circuits including SNS-sensory feedback loops that may control lipolysis, and increases or decreases in WAT SNS drive/NE inhibit and stimulate white adipocyte proliferation, respectively.About:
This article is published in Frontiers in Neuroendocrinology.The article was published on 2014-10-01 and is currently open access. It has received 248 citations till now. The article focuses on the topics: Lipolysis & White adipose tissue.read more
Citations
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Journal ArticleDOI
Neural Control of Energy Balance: Translating Circuits to Therapies
TL;DR: Current knowledge linking the neural circuits regulating energy and glucose balance with current and potential pharmacotherapeutic and surgical interventions for the treatment of obesity and diabetes is summarized.
Journal ArticleDOI
FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity.
Xiao-Qing Xiong,Dan Chen,Hai-Jian Sun,Lei Ding,Jue-Jin Wang,Qi Chen,Yuehua Li,Ye-Bo Zhou,Ying Han,Feng Zhang,Xing-Ya Gao,Yu-Ming Kang,Guo-Qing Zhu +12 more
TL;DR: It is indicated that FNDC5/irisin ameliorates glucose/lipid metabolic derangements and insulin resistance in obese mice, and enhances lipolysis via cAMP-PKA-HSL/perilipin pathway.
Journal ArticleDOI
Leptin and brain–adipose crosstalks
TL;DR: A review of anatomical, genetic and pharmacological studies on the neural regulation of adipose function, including lipolysis, non-shivering thermogenesis, browning and leptin secretion, can be found in this article.
Journal ArticleDOI
Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications.
Almudena Gómez-Hernández,Nuria Beneit,Sabela Díaz-Castroverde,Oscar Escribano,Oscar Escribano +4 more
TL;DR: In order to combat obesity and its related complications, as a complement to conventional treatments, a new insight is focusing on the role of the thermogenic function of brown and perivascular adipose tissues as a promising therapy in humans.
Journal ArticleDOI
Obesity, adipokines and neuroinflammation.
TL;DR: The role of two of the better-studied members of this family, leptin and adiponectin, are focused on, with particular emphasis on their role in neuro-immune interactions, neuroinflammation and subsequent brain diseases.
References
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Journal ArticleDOI
Positional cloning of the mouse obese gene and its human homologue
Yiying Zhang,Ricardo Proenca,Ricardo Proenca,Margherita Maffei,Marisa Barone,Marisa Barone,Lori Leopold,Lori Leopold,Jeffrey M. Friedman,Jeffrey M. Friedman +9 more
TL;DR: The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.
Journal ArticleDOI
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Michael J. Caterina,Mark Schumacher,Makoto Tominaga,Tobias A. Rosen,Jon D. Levine,David Julius +5 more
TL;DR: The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
Journal ArticleDOI
Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control
TL;DR: It is shown that sympathetic and parasympathetic nervous activity make frequency-specific contributions to the heart rate power spectrum, and that renin-angiotensin system activity strongly modulates the amplitude of the spectral peak located at 0.04 hertz.
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Decreased heart rate variability and its association with increased mortality after acute myocardial infarction
Robert E. Kleiger,Robert E. Kleiger,Robert E. Kleiger,J. Philip Miller,J. Philip Miller,J. Philip Miller,J.Thomas Bigger,J.Thomas Bigger,J.Thomas Bigger,Arthur J. Moss,Arthur J. Moss,Arthur J. Moss +11 more
TL;DR: HR variability remained a significant predictor of mortality after adjusting for clinical, demographic, other Holter features and ejection fraction, and a hypothesis to explain this finding is that decreased HR variability correlates with increased sympathetic or decreased vagal tone, which may predispose to ventricular fibrillation.
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A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats
A. J. De Bold,A. J. De Bold,H.B. Borenstein,H.B. Borenstein,A. T. Veress,A. T. Veress,H. Sonnenberg,H. Sonnenberg +7 more
TL;DR: It is concluded that the atrial extract contained an extremely powerful inhibitor of renal tubular NaCl re absorption, which caused a rapid, more than 30-fold increase of sodium and chloride excretions, while urine volume and potassium excretion doubled.