Journal ArticleDOI
Neuroendocrine mechanisms of innate states of attenuated responsiveness of the hypothalamo-pituitary adrenal axis to stress.
Alan J Tilbrook,Iain J. Clarke +1 more
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TLDR
The neuroendocrine mechanisms for stress hyporesponsiveness are likely to include reduced synthesis and secretion of corticotropin releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus as a result of enhanced glucocorticoid negative feedback and/or reduced noradrenergic stimulatory input from the brain stem.About:
This article is published in Frontiers in Neuroendocrinology.The article was published on 2006-09-01. It has received 109 citations till now. The article focuses on the topics: Corticotropin-releasing hormone & Vasopressin.read more
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Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems
Taka-aki Koshimizu,Kazuaki Nakamura,Nobuaki Egashira,Masami Hiroyama,Hiroshi Nonoguchi,Akito Tanoue +5 more
TL;DR: This report reviews the findings in this important field by covering a wide range of research, from the molecular physiology of V1a and V1b receptors to studies on whole animals, including gene knockout/knockdown studies.
Journal ArticleDOI
Adaptive Responses of the Maternal Hypothalamic-Pituitary-Adrenal Axis during Pregnancy and Lactation
TL;DR: The mechanism of reduced CRF neurone responses to physical stressors in pregnancy is the suppression of noradrenaline release in the PVN by an up‐regulated endogenous opioid mechanism, which is induced by neuroactive steroid produced from progesterone.
Journal ArticleDOI
Paracrinicity: The Story of 30 Years of Cellular Pituitary Crosstalk
TL;DR: In the anterior pituitary, paracrine communication and autocrine loops that operate during fetal and postnatal development in mammals and lower vertebrates have been shown in all hormonal cell types and in folliculo‐stellate cells.
Journal ArticleDOI
Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men.
Martin Clodi,Greisa Vila,René Geyeregger,Michaela Riedl,Thomas M. Stulnig,Joachim Struck,Thomas A. Luger,Anton Luger +7 more
TL;DR: This paper used experimental bacterial endotoxinemia to examine the role of exogenous oxytocin administrated in rodents. But they did not examine the effect of the exogenous drugs on the performance of their experiments.
Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men
Greisa Vila,Martin Clodi,René Geyeregger,Michaela Riedl,Thomas M. Stulnig,Joachim Struck,Thomas A. Luger,Anton Luger +7 more
TL;DR: Oxytocin decreases the neuroendocrine and cytokine activation caused by bacterial endotoxin in men, possibly due to the pharmacological modulation of the cholinergic anti-inflammatory pathway.
References
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The Oxytocin Receptor System: Structure, Function, and Regulation
Gerald Gimpl,Falk Fahrenholz +1 more
TL;DR: The regulation by gonadal and adrenal steroids is one of the most remarkable features of the OT system and is, unfortunately, the least understood.
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Two Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation
TL;DR: It is concluded that CORT action via CR may be involved in a tonic (permissive) influence on brain function with the septohippocampal complex as a primary target.
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Brain corticosteroid receptor balance in health and disease.
TL;DR: The balance in actions mediated by the two corticosteroid receptor types in these neurons appears critical for neuronal excitability, stress responsiveness, and behavioral adaptation and Dysregulation of this MR/GR balance brings neurons in a vulnerable state with consequences for regulation of the stress response and enhanced vulnerability to disease in genetically predisposed individuals.
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Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress.
TL;DR: CRH antagonists may be useful in human pathologic states, such as melancholic depression and chronic anxiety, associated with chronic hyperactivity of the stress system, along with predictable behavioral, neuroendocrine, metabolic and immune changes, based on the interrelations outlined above.
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Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
TL;DR: The functional and neuroanatomical data obtained suggest that disease processes involving inappropriate stress control involve dysfunction of processive stress pathways.