New Mechanisms of Pulmonary Fibrosis
Robert M. Strieter,Borna Mehrad +1 more
TLDR
This review discusses evolving conceptual mechanisms for the pathogenesis of pulmonary fibrosis relevant to idiopathic pulmonary fibrot, including the importance of the integrity of the alveolar-capillary barrier basement membrane to conserving the architecture of the injured lung.About:
This article is published in Chest.The article was published on 2009-11-01 and is currently open access. It has received 242 citations till now. The article focuses on the topics: Pulmonary fibrosis & Idiopathic pulmonary fibrosis.read more
Citations
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Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
Alfiya Akhmetshina,Katrin Palumbo,Clara Dees,Christina Bergmann,Paulius Venalis,Pawel Zerr,Angelika Horn,Trayana Kireva,Christian Beyer,Jochen Zwerina,Holm Schneider,Anika Sadowski,Marc Oliver Riener,Ormond A. MacDougald,Oliver Distler,Georg Schett,Jörg H W Distler +16 more
TL;DR: It is demonstrated that canonical Wnt signalling is necessary for TGF-β-mediated fibrosis and highlight a key role for the interaction of both pathways in the pathogenesis of fibrotic diseases.
Journal ArticleDOI
Evolving challenges in hepatic fibrosis
TL;DR: Both apoptosis and senescence have been recognized as orchestrated programs that eliminate fibrogenic cells during resolution of liver fibrosis and their translation into new diagnostic tools and treatments.
Journal ArticleDOI
miR-29 Is a Major Regulator of Genes Associated with Pulmonary Fibrosis
Leah Cushing,Ping Ping Kuang,Jun Qian,Fengzhi Shao,Junjie Wu,Frederic F. Little,Victor J. Thannickal,Wellington V. Cardoso,Jining Lu +8 more
TL;DR: A large-scale screening for miRNAs potentially involved in bleomycin-induced fibrosis found expression of miR-29 family members significantly reduced in fibrotic lungs, and gene expression profiles of human fetal lung fibroblast IMR-90 cells in which endogenous miR -29 was knocked down strongly suggest a role of mi R-29 in the pathogenesis of pulmonary fibrosis.
Journal ArticleDOI
The pathogenesis of idiopathic pulmonary fibrosis.
TL;DR: It is shown that in the presence of persisting injurious pathways, or disrupted repair pathways, activated TGF-β can lead to enhanced epithelial apoptosis and epithelial-to-mesenchymal transition (EMT) as well as fibroblast, and fibrocyte, transformation into myofibroblasts which are resistant to apoptosis.
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Antifibrotic activities of pirfenidone in animal models
TL;DR: The consistent antifibrotic activity of pirfenidone in a broad array of animal models provides a strong preclinical rationale for the clinical characterisation of Pirfenidones in pulmonary fibrosis and, potentially, other conditions with a significant fibrotic component.
References
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Book
Inflammation: Basic principles and clinical correlates
TL;DR: This poster describes the cellular components of Inflammation, the mechanisms of response to inflammation, and the role of cytokines in the regulation of these components.
Journal ArticleDOI
Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy.
TL;DR: The hypothesis that idiopathic pulmonary fibrosis is a fibrotic rather than an inflammatory disease is examined, and the therapeutic implications of these findings are discussed.
Journal ArticleDOI
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
Zhou Zhu,Robert J. Homer,Robert J. Homer,Zhonde Wang,Qingsheng Chen,Gregory P. Geba,Gregory P. Geba,Jingming Wang,Yong Zhang,Jack A. Elias +9 more
TL;DR: The targeted pulmonary expression of IL-13 causes a mononuclear and eosinophilic inflammatory response, mucus cell metaplasia, airway fibrosis, eotaxin production, airways obstruction, and nonspecific AHR in transgene-positive animals.
Journal ArticleDOI
Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair.
TL;DR: Blood-borne fibrocytes contribute to scar formation and may play an important role both in normal wound repair and in pathological fibrotic responses.
Journal ArticleDOI
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
Kevin K. Kim,Matthias C. Kugler,Paul J. Wolters,Liliane Robillard,Michael G. Galvez,Alexis N. Brumwell,Dean Sheppard,Harold A. Chapman +7 more
TL;DR: Alveolar epithelial cells are revealed as progenitors for fibroblasts in vivo and implicate the provisional extracellular matrix as a key regulator of epithelial transdifferentiation during fibrogenesis.
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