Journal ArticleDOI
Noncoding translation: Quality control in the BAG.
TLDR
Kesner et al. as discussed by the authors investigated the mechanism by which the BAG6 complex exerts quality control over non-coding translation while targeting stable, noncanonical polypeptides to cellular membranes.About:
This article is published in Molecular Cell.The article was published on 2023-06-01. It has received 0 citations till now. The article focuses on the topics: Medicine & Translation (biology).read more
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Journal ArticleDOI
Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
TL;DR: A ribosomesome-profiling strategy based on the deep sequencing of ribosome-protected mRNA fragments is presented and enables genome-wide investigation of translation with subcodon resolution and is used to monitor translation in budding yeast under both rich and starvation conditions.
Journal ArticleDOI
Proto-genes and de novo gene birth
Anne-Ruxandra Carvunis,Thomas Rolland,Ilan Wapinski,Michael A. Calderwood,Muhammed A. Yildirim,Nicolas Simonis,Nicolas Simonis,Benoit Charloteaux,Benoit Charloteaux,César A. Hidalgo,Justin Barbette,Balaji Santhanam,Gloria A. Brar,Jonathan S. Weissman,Aviv Regev,Aviv Regev,Nicolas Thierry-Mieg,Michael E. Cusick,Marc Vidal +18 more
TL;DR: In this article, the authors formalize an evolutionary model according to which functional genes evolve de novo through transitory proto-genes generated by widespread translational activity in non-genic sequences.
Journal ArticleDOI
Pervasive functional translation of noncanonical human open reading frames
Jin Chen,Andreas-David Brunner,J. Zachery Cogan,James K. Nuñez,Alexander P. Fields,Britt Adamson,Daniel N. Itzhak,Jason Y. Li,Matthias Mann,Matthias Mann,Manuel D. Leonetti,Jonathan S. Weissman +11 more
TL;DR: A systematic CRISPR-based screening strategy is exploited to identify hundreds of noncanonical CDSs that are essential for cellular growth and whose disruption elicits specific, robust transcriptomic and phenotypic changes in human cells.
Journal ArticleDOI
Conserved Regulation of Cardiac Calcium Uptake by Peptides Encoded in Small Open Reading Frames
Emile G. Magny,Jose Ignacio Pueyo,Frances M. G. Pearl,Miguel Angel Cespedes,Jeremy E. Niven,Sarah A. Bishop,Juan Pablo Couso +6 more
TL;DR: Two smORF-encoded peptides of less than 30 amino acids regulating calcium transport and, hence, regular heart contraction, in the fruit fly Drosophila heart are described, suggesting that the mechanisms for heart regulation are ancient and that smORFs may be a fundamental genome component that should be studied systematically.
Journal ArticleDOI
Accurate annotation of human protein-coding small open reading frames
Thomas F. Martinez,Qian Chu,Cynthia J. Donaldson,Dan Tan,Maxim N. Shokhirev,Alan Saghatelian +5 more
TL;DR: An improved workflow combining de novo transcriptome assembly and Ribo-seq validated by cellular antigen display is developed to maximize small peptide discovery, leading to identification of thousands of unannotated protein-coding smORFs.
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