Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes suggests that hPXR is less sensitive than mouse PXR to nonylphenol treatment.
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It is shown that PXR is required for NP-mediated CYP-induction, mP XR mediates greater CYP induction than hPXR in vivo, and the presence of PXr, especially mPxR, is associated with altered histopathology and increased clearance of NP.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 2011-05-01 and is currently open access. It has received 19 citations till now.read more
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Xenobiotic metabolism in the zebrafish: a review of the spatiotemporal distribution, modulation and activity of Cytochrome P450 families 1 to 3.
Moayad A. Saad,Kate Cavanaugh,Evy Verbueken,Casper Pype,Christophe Casteleyn,Chris Van Ginneken,Steven Van Cruchten +6 more
TL;DR: The available spatiotemporal, modulation and activity data on zebrafish CYP 1-3 families are reviewed in this paper and compared with human CYP data, showing distinct evolutionary and orthological similarities with humans.
Journal ArticleDOI
PXR variants: the impact on drug metabolism and therapeutic responses
TL;DR: The pregnane X receptor (PXR) plays an important and diverse role in mediating xenobiotic induction of drug-metabolizing enzymes and transporters and their expression differs in various human cancers and also in cancerous tissue compared to adjacent normal tissues.
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Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice
Ramiya Kumar,Linda C. Mota,Elizabeth J. Litoff,John P. Rooney,W. Tyler Boswell,Elliott Courter,Charles M. Henderson,Juan P. Hernandez,J. Christopher Corton,David D. Moore,William S. Baldwin +10 more
TL;DR: The ratio of 6α-/15α-hydroxylase activity, a biomarker of sexual dimorphism in the liver, indicates masculinization of female CAR-null mice, suggesting a role for CAR in the regulation of sexually dimorphic liver CYP profiles.
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Chemical Activation of the Constitutive Androstane Receptor Leads to Activation of Oxidant-Induced Nrf2
John P. Rooney,John P. Rooney,Keiyu Oshida,Keiyu Oshida,Ramiya Kumar,William S. Baldwin,J. Christopher Corton +6 more
TL;DR: Evidence is provided that Nrf2 activation often occurs after exposure to xenobiotic chemicals, is tightly linked to activation of CAR, and does not require induction of 3 Cyp2b genes secondary to CAR activation.
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Xenobiotic receptor humanized mice and their utility
Nico Scheer,C. Roland Wolf +1 more
TL;DR: This review provides an overview of the different xenobiotic receptor humanized mouse models described to date and will summarize how these models can be applied in basic research and improve drug discovery and development.
References
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Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance.
Dana W. Kolpin,Edward T. Furlong,Michael T. Meyer,E. Michael Thurman,Steven D. Zaugg,Larry B. Barber,Herbert T. Buxton +6 more
TL;DR: The U.S. Geological Survey used five newly developed analytical methods to measure concentrations of 95 organic wastewater contaminants (OWCs) in water samples from a network of 139 streams across 30 states during 1999 and 2000 as mentioned in this paper.
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Encyclopedia of Chemical Technology
TL;DR: Encyclopedia of Chemical Technology The Third Edition of the Encycled encyclopedia of chemical technology as mentioned in this paper is built on the solid foundation of the previous editions of the encyclopedia, which has been updated and updated and many new subjects have been added to reflect changes in chemical technology through the 1970s.
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An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway
Steven A. Kliewer,John T. Moore,Laura E. Wade,Jeff L. Staudinger,Michael A. Watson,Stacey A. Jones,David D. McKee,Beverly B. Oliver,Timothy M. Willson,Rolf Zetterström,Thomas Perlmann,Jürgen M. Lehmann +11 more
TL;DR: The results provide evidence for the existence of a novel steroid hormone signaling pathway with potential implications in the regulation of steroid hormone and sterol homeostasis and the expression of the CYP3A family of steroid hydroxylases and modulates sterol and bile acid biosynthesis in vivo.
Journal Article
Processing of gene expression data generated by quantitative real-time RT-PCR.
TL;DR: The Q-Gene software application is a tool to cope with complex quantitative real-time PCR experiments at a high-throughput scale and considerably expedites and rationalizes the experimental setup, data analysis, and data management while ensuring highest reproducibility.
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Environmentally persistent alkylphenolic compounds are estrogenic
TL;DR: It is shown that a number of alkylphenolic compounds, used in a variety of commercial products and found in river water, are estrogenic in fish, birds, and mammals and capable of stimulating vitellogenin gene expression in trout hepatocytes, gene transcription in transfected cells, and the growth of breast cancer cell lines.