Oesophageal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
TLDR
In the EU, the highest age-standardised incidence rates for oesophageal cancer are in the Netherlands for men and the UK for women, and variation between countries is high and may reflect different prevalence of risk factors, use of screening and diagnostic methods.About:
This article is published in Annals of Oncology.The article was published on 2013-10-01 and is currently open access. It has received 810 citations till now. The article focuses on the topics: European union & Cancer.read more
Citations
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Preoperative chemotherapy versus chemoradiotherapy in locally advanced adenocarcinomas of the oesophagogastric junction (POET): Long-term results of a controlled randomised trial
Michael Stahl,Martin K. Walz,Jorge Riera-Knorrenschild,Martin Stuschke,Andreas Sandermann,Michael Bitzer,Hansjochen Wilke,Wilfried Budach +7 more
TL;DR: Long-term follow-up data suggest a benefit in local progression-free survival when radiotherapy was added to preoperative chemotherapy in patients with locally advanced adenocarcinoma of the oesophagogastric junction.
Journal ArticleDOI
KEYNOTE-590: Phase III study of first-line chemotherapy with or without pembrolizumab for advanced esophageal cancer.
Ken Kato,Manish A. Shah,Peter C. Enzinger,Jaafar Bennouna,Lin Shen,Antoine Adenis,Jong-Mu Sun,Byoung Chul Cho,Mustafa Ozguroglu,Takashi Kojima,Vladimir Kostorov,Cinta Hierro,Ying Zhu,Lee Anne McLean,Sukrut Shah,Toshihiko Doi +15 more
TL;DR: The design and rationale for the randomized, double-blind, placebo-controlled Phase III KEYNOTE-590 study, which will be conducted to investigate pembrolizumab in combination with chemotherapy as first-line treatment in patients with advanced esophageal or EGJ cancer, are described.
Journal ArticleDOI
Phase II study of chemoselection with docetaxel plus cisplatin and 5-fluorouracil induction chemotherapy and subsequent conversion surgery for locally advanced unresectable oesophageal cancer
Tomoya Yokota,Ken Kato,Yasuo Hamamoto,Yasuhiro Tsubosa,Hirofumi Ogawa,Yoshinori Ito,Hiroki Hara,Takashi Ura,Takashi Kojima,Keisho Chin,Shuichi Hironaka,Takayuki Kii,Yasushi Kojima,Yasunori Akutsu,Hisayuki Matsushita,Kentaro Kawakami,Keita Mori,Yushi Nagai,Chika Asami,Yuko Kitagawa +19 more
TL;DR: Chemoselection with DCF-ICT followed by CS as a multidisciplinary treatment strategy showed promising signs of tolerability and efficacy in patients with locally advanced unresectable SCC of the oesophagus.
Journal ArticleDOI
Esophageal carcinoma: Towards targeted therapies.
TL;DR: Current trends towards more targeted therapies in esophageal cancers are discussed, taking into consideration unique features of ESCCs and EACs.
Journal ArticleDOI
NeoFLOT: Multicenter phase II study of perioperative chemotherapy in resectable adenocarcinoma of the gastroesophageal junction or gastric adenocarcinoma-Very good response predominantly in patients with intestinal type tumors.
Christoph Schulz,Frank Kullmann,Volker Kunzmann,Martin Fuchs,Michael Geissler,Ursula Vehling-Kaiser,Heribert Stauder,Axel Wein,Salah-Eddin Al-Batran,Thomas Kubin,Claus Schäfer,Sebastian Stintzing,Clemens Giessen,Dominik Paul Modest,Karsten Ridwelski,Volker Heinemann +15 more
TL;DR: This study indicates that intensified NACT with 6 cycles of FLOT is highly effective and tolerable in resectable GEC.
References
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Book
AJCC Cancer Staging Manual
Mahul B. Amin,Stephen B. Edge,Frederick L. Greene,David R. Byrd,Robert K. Brookland,Mary Kay Washington,Jeffrey E. Gershenwald,Carolyn C. Compton,Kenneth R. Hess,Daniel C. Sullivan,J. Milburn Jessup,James D. Brierley,Lauri E. Gaspar,Richard L. Schilsky,Charles M. Balch,David P. Winchester,Elliot A. Asare,Martin Madera,Donna M. Gress,Laura R. Meyer +19 more
TL;DR: Purposes and Principles of Cancer Staging and End-Results Reporting are explained.
Journal ArticleDOI
Perioperative Chemotherapy versus Surgery Alone for Resectable Gastroesophageal Cancer
David Cunningham,William H. Allum,Sally P. Stenning,Jeremy Thompson,Marianne Nicolson,J. Howard Scarffe,F. Lofts,Stephen Falk,Timothy Iveson,David Smith,Ruth E Langley,Monica Verma,Simon Weeden,Yu Jo Chua +13 more
TL;DR: In patients with operable gastric or lower esophageal adenocarcinomas, a perioperative regimen of ECF decreased tumor size and stage and significantly improved progression-free and overall survival.
Journal ArticleDOI
Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012
J. Ferlay,Eva Steliarova-Foucher,Joannie Lortet-Tieulent,Sonia Rosso,Jan Willem Coebergh,Harry Comber,David Forman,Freddie Bray +7 more
TL;DR: Up-to-date estimates of the cancer burden in Europe alongside the description of the varying distribution of common cancers at both the regional and country level provide a basis for establishing priorities to cancer control actions in Europe.
Journal ArticleDOI
Hospital Volume and Surgical Mortality in the United States
John D. Birkmeyer,Andrea E. Siewers,Emily Finlayson,Therese A. Stukel,F. Lee Lucas,Ida Batista,H. Gilbert Welch,David E. Wennberg +7 more
TL;DR: Mortality decreased as volume increased for all 14 types of procedures, but the relative importance of volume varied markedly according to the type of procedure.
Journal ArticleDOI
Preoperative Chemoradiotherapy for Esophageal or Junctional Cancer
TL;DR: Preoperative chemoradiotherapy improved survival among patients with potentially curable esophageal or esophagogastric-junction cancer and the regimen was associated with acceptable adverse-event rates.
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