Oesophageal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
TLDR
In the EU, the highest age-standardised incidence rates for oesophageal cancer are in the Netherlands for men and the UK for women, and variation between countries is high and may reflect different prevalence of risk factors, use of screening and diagnostic methods.About:
This article is published in Annals of Oncology.The article was published on 2013-10-01 and is currently open access. It has received 810 citations till now. The article focuses on the topics: European union & Cancer.read more
Citations
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Predictive molecular markers in metastases to the central nervous system: recent advances and future avenues
Anna S. Berghoff,Rupert Bartsch,Adelheid Wöhrer,Berthold Streubel,Peter Birner,Johan M. Kros,Priscilla K. Brastianos,Andreas von Deimling,Matthias Preusser +8 more
TL;DR: Clinical relevant biomarker tests that should be considered in neurosurgical specimens based on the current recommendations of the European Society of Medical Oncology (ESMO) or the National Comprehensive Cancer Network (NCCN) for the most relevant primary tumor types are summarized.
Journal ArticleDOI
Brachytherapy for the Palliation of Dysphagia Owing to Esophageal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies
Lorenzo Fuccio,Daniele Mandolesi,Andrea Farioli,Cesare Hassan,Leonardo Frazzoni,Alessandra Guido,Nicola de Bortoli,Savino Cilla,Chiara Pierantoni,Francesco Saverio Violante,Franco Bazzoli,Alessandro Repici,Alessio G. Morganti +12 more
TL;DR: Brachytherapy is a highly effective and relatively safe treatment option therefore its underuse is no longer justified and further studies should investigate the optimal radiation dose and number of fractions able to achieve the highest DFS rates.
Journal ArticleDOI
Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study
E R C Hagens,Mark I. van Berge Henegouwen,Johanna W. van Sandick,Miguel A. Cuesta,Donald L. van der Peet,Joos Heisterkamp,Grard A. P. Nieuwenhuijzen,Camiel Rosman,Joris J. Scheepers,Meindert N. Sosef,Richard van Hillegersberg,Sjoerd M. Lagarde,Magnus Nilsson,Jari Räsänen,Philippe Nafteux,Piet Pattyn,Arnulf H. Hölscher,Wolfgang Schröder,Paul M. Schneider,Christophe Mariette,Carlo Castoro,Luigi Bonavina,Riccardo Rosati,Giovanni de Manzoni,Sandro Mattioli,Josep Garcia,Manuel Pera,M Griffin,Paul Wilkerson,M. Asif Chaudry,Bruno Sgromo,Olga Tucker,Edward Cheong,K Moorthy,Thomas N. Walsh,John V. Reynolds,Yuji Tachimori,Haruhiro Inoue,Hisahiro Matsubara,Shin-ichi Kosugi,Haiquan Chen,Simon Law,C S Pramesh,Shailesh P. Puntambekar,Sudish Murthy,Philip Linden,Wayne L. Hofstetter,Madhan Kumar Kuppusamy,K. Robert Shen,Gail E. Darling,Flávio D. Sabino,Peter P. Grimminger,Sybren L. Meijer,Jacques J. Bergman,Maarten C.C.M. Hulshof,Hanneke W. M. van Laarhoven,Banafsche Mearadji,Roel J. Bennink,Jouke T. Annema,Marcel G. W. Dijkgraaf,Suzanne S. Gisbertz +60 more
TL;DR: The TIGER study will provide a roadmap of the location of lymph node metastases in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph nodes metastases, pre-operative diagnostics, neo-adjuvant therapy and survival.
Journal ArticleDOI
Integrated PPI- and WGCNA-Retrieval of Hub Gene Signatures Shared Between Barrett's Esophagus and Esophageal Adenocarcinoma.
Asma Sindhoo Nangraj,Gurudeeban Selvaraj,Satyavani Kaliamurthi,Aman Chandra Kaushik,Aman Chandra Kaushik,William C. Cho,Dong-Qing Wei,Dong-Qing Wei +7 more
TL;DR: It is concluded that the PPI complex and WGCNA co-expression network highlight the importance of phenotypic identifying hub gene signatures for BE and EAC.
Journal ArticleDOI
Epstein-Barr virus and mismatch repair deficiency status differ between oesophageal and gastric cancer: A large multi-centre study.
Lindsay C. Hewitt,Imran Inam,Y. Saito,Takaki Yoshikawa,A. Quaas,A. Hoelscher,Elfriede Bollschweiler,Gregorio E. Fazzi,Veerle Melotte,Ruth E Langley,Matthew Nankivell,David Cunningham,William H. Allum,Gordon G A Hutchins,Heike I. Grabsch +14 more
TL;DR: This is the largest study to date indicating that EBV and MMRdef do not play a role in OeC carcinogenesis in contrast to GC, and the potential clinical usefulness of determining MMRdef/EBV status to screen patients for eligibility for immune-targeting therapy differs between O eC and GC patients.
References
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Book
AJCC Cancer Staging Manual
Mahul B. Amin,Stephen B. Edge,Frederick L. Greene,David R. Byrd,Robert K. Brookland,Mary Kay Washington,Jeffrey E. Gershenwald,Carolyn C. Compton,Kenneth R. Hess,Daniel C. Sullivan,J. Milburn Jessup,James D. Brierley,Lauri E. Gaspar,Richard L. Schilsky,Charles M. Balch,David P. Winchester,Elliot A. Asare,Martin Madera,Donna M. Gress,Laura R. Meyer +19 more
TL;DR: Purposes and Principles of Cancer Staging and End-Results Reporting are explained.
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Perioperative Chemotherapy versus Surgery Alone for Resectable Gastroesophageal Cancer
David Cunningham,William H. Allum,Sally P. Stenning,Jeremy Thompson,Marianne Nicolson,J. Howard Scarffe,F. Lofts,Stephen Falk,Timothy Iveson,David Smith,Ruth E Langley,Monica Verma,Simon Weeden,Yu Jo Chua +13 more
TL;DR: In patients with operable gastric or lower esophageal adenocarcinomas, a perioperative regimen of ECF decreased tumor size and stage and significantly improved progression-free and overall survival.
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Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012
J. Ferlay,Eva Steliarova-Foucher,Joannie Lortet-Tieulent,Sonia Rosso,Jan Willem Coebergh,Harry Comber,David Forman,Freddie Bray +7 more
TL;DR: Up-to-date estimates of the cancer burden in Europe alongside the description of the varying distribution of common cancers at both the regional and country level provide a basis for establishing priorities to cancer control actions in Europe.
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Hospital Volume and Surgical Mortality in the United States
John D. Birkmeyer,Andrea E. Siewers,Emily Finlayson,Therese A. Stukel,F. Lee Lucas,Ida Batista,H. Gilbert Welch,David E. Wennberg +7 more
TL;DR: Mortality decreased as volume increased for all 14 types of procedures, but the relative importance of volume varied markedly according to the type of procedure.
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Preoperative Chemoradiotherapy for Esophageal or Junctional Cancer
TL;DR: Preoperative chemoradiotherapy improved survival among patients with potentially curable esophageal or esophagogastric-junction cancer and the regimen was associated with acceptable adverse-event rates.
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