Oesophageal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
TLDR
In the EU, the highest age-standardised incidence rates for oesophageal cancer are in the Netherlands for men and the UK for women, and variation between countries is high and may reflect different prevalence of risk factors, use of screening and diagnostic methods.About:
This article is published in Annals of Oncology.The article was published on 2013-10-01 and is currently open access. It has received 810 citations till now. The article focuses on the topics: European union & Cancer.read more
Citations
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Complete and sustained objective response per RECIST to Irvalec (PM02734) in undifferentiated large cell esophageal adenocarcinoma: A case report and a review of the literature.
Ramón Salazar,Carmen Cuadra,Marta Gil-Martín,Andrea Vandermeeren,Vicente Alfaro,Cinthya Coronado +5 more
TL;DR: A 58-year-old Caucasian male previously treated with cisplatin/5-fluorouracil, docetaxel and carboplatin/plitidepsin who received treatment with a novel antitumor agent, Irvalec (PM02734), as fourth line is reported.
Journal ArticleDOI
DNA epigenetic signature predictive of benefit from neoadjuvant chemotherapy in oesophageal adenocarcinoma: results from the MRC OE02 trial.
Raghav Sundar,Raghav Sundar,Alvin Wei Tian Ng,Hermioni Zouridis,Hermioni Zouridis,Nisha Padmanabhan,Taotao Sheng,Shenli Zhang,Ming Hui Lee,Wen Fong Ooi,Aditi Qamra,Imran Inam,Lindsay C. Hewitt,Jimmy Bok Yan So,Jimmy Bok Yan So,Vivien Koh,Vivien Koh,Matthew Nankivell,Ruth E Langley,William H. Allum,David Cunningham,Steven G. Rozen,Wei Peng Yong,Wei Peng Yong,Heike I. Grabsch,Heike I. Grabsch,Patrick Tan +26 more
TL;DR: This is the first and largest study of DNA methylation in patients with OAC uniformly treated in a randomised phase III trial and identified an epigenetic signature that may serve as a predictive biomarker for chemotherapy benefit in OAC.
Journal ArticleDOI
Neoadjuvant chemoradiation treatment followed by surgery for esophageal cancer: there is much more than the mandard tumor regression score
Lieven Depypere,Johnny Moons,T. Lerut,G. De Hertogh,Xavier Sagaert,Willy Coosemans,H. Van Veer,A Renders,P. Nafteux +8 more
TL;DR: After nCRT followed by surgery for esophageal carcinoma, number of residual positive lymph nodes as well as TRR are prognosticators for OS and Minor TRR, ypT and extracapsular lymph node invasion are progosticators for recurrence.
Journal ArticleDOI
SOURCE: Prediction Models for Overall Survival in Patients With Metastatic and Potentially Curable Esophageal and Gastric Cancer.
Héctor G. van den Boorn,Ameen Abu-Hanna,Nadia Haj Mohammad,Maarten C.C.M. Hulshof,Suzanne S. Gisbertz,Bastiaan R. Klarenbeek,Marije Slingerland,Laurens V. Beerepoot,Tom Rozema,Mirjam A. G. Sprangers,Rob H.A. Verhoeven,Martijn G.H. van Oijen,Koos H. Zwinderman,Hanneke W. M. van Laarhoven +13 more
TL;DR: In this article, the authors developed prediction models of overall survival at diagnosis for patients with potentially curable and metastatic esophageal and gastric cancer (the SOURCE study), which were validated with temporal cross-validation on their C-index and calibration.
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Validation of the eighth clinical American Joint Committee on Cancer stage grouping for esophageal cancer.
Hani Oweira,Jan Schmidt,Arianeb Mehrabi,Hasan Kulaksiz,Paul Schneider,Othmar Schöb,Anwar Giryes,Omar Abdel-Rahman +7 more
TL;DR: Minimal improvement was achieved by the eighth clinical AJCC staging system for esophageal cancer and p-values for pairwise comparisons were nonsignificant in many comparisons.
References
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Book
AJCC Cancer Staging Manual
Mahul B. Amin,Stephen B. Edge,Frederick L. Greene,David R. Byrd,Robert K. Brookland,Mary Kay Washington,Jeffrey E. Gershenwald,Carolyn C. Compton,Kenneth R. Hess,Daniel C. Sullivan,J. Milburn Jessup,James D. Brierley,Lauri E. Gaspar,Richard L. Schilsky,Charles M. Balch,David P. Winchester,Elliot A. Asare,Martin Madera,Donna M. Gress,Laura R. Meyer +19 more
TL;DR: Purposes and Principles of Cancer Staging and End-Results Reporting are explained.
Journal ArticleDOI
Perioperative Chemotherapy versus Surgery Alone for Resectable Gastroesophageal Cancer
David Cunningham,William H. Allum,Sally P. Stenning,Jeremy Thompson,Marianne Nicolson,J. Howard Scarffe,F. Lofts,Stephen Falk,Timothy Iveson,David Smith,Ruth E Langley,Monica Verma,Simon Weeden,Yu Jo Chua +13 more
TL;DR: In patients with operable gastric or lower esophageal adenocarcinomas, a perioperative regimen of ECF decreased tumor size and stage and significantly improved progression-free and overall survival.
Journal ArticleDOI
Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012
J. Ferlay,Eva Steliarova-Foucher,Joannie Lortet-Tieulent,Sonia Rosso,Jan Willem Coebergh,Harry Comber,David Forman,Freddie Bray +7 more
TL;DR: Up-to-date estimates of the cancer burden in Europe alongside the description of the varying distribution of common cancers at both the regional and country level provide a basis for establishing priorities to cancer control actions in Europe.
Journal ArticleDOI
Hospital Volume and Surgical Mortality in the United States
John D. Birkmeyer,Andrea E. Siewers,Emily Finlayson,Therese A. Stukel,F. Lee Lucas,Ida Batista,H. Gilbert Welch,David E. Wennberg +7 more
TL;DR: Mortality decreased as volume increased for all 14 types of procedures, but the relative importance of volume varied markedly according to the type of procedure.
Journal ArticleDOI
Preoperative Chemoradiotherapy for Esophageal or Junctional Cancer
TL;DR: Preoperative chemoradiotherapy improved survival among patients with potentially curable esophageal or esophagogastric-junction cancer and the regimen was associated with acceptable adverse-event rates.
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