Oesophageal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
TLDR
In the EU, the highest age-standardised incidence rates for oesophageal cancer are in the Netherlands for men and the UK for women, and variation between countries is high and may reflect different prevalence of risk factors, use of screening and diagnostic methods.About:
This article is published in Annals of Oncology.The article was published on 2013-10-01 and is currently open access. It has received 810 citations till now. The article focuses on the topics: European union & Cancer.read more
Citations
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Nivolumab versus chemotherapy in patients with advanced oesophageal squamous cell carcinoma refractory or intolerant to previous chemotherapy (ATTRACTION-3): a multicentre, randomised, open-label, phase 3 trial
Ken Kato,Byoung Chul Cho,Masanobu Takahashi,Morihito Okada,Chen Yuan Lin,Keisho Chin,Shigenori Kadowaki,Myung-Ju Ahn,Yasuo Hamamoto,Yuichiro Doki,Chueh Chuan Yen,Yutaro Kubota,Sung Bae Kim,Chih-Hung Hsu,Eva Holtved,Ioannis Xynos,Mamoru Kodani,Yuko Kitagawa +17 more
TL;DR: Overall survival was significantly improved in the nivolumab group compared with the chemotherapy group, and a favourable safety profile compared with chemotherapy in previously treated advanced oesophageal squamous cell carcinoma patients.
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Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial.
Hong Yang,Hui Liu,Yuping Chen,Chengchu Zhu,Wentao Fang,Zhentao Yu,Weimin Mao,Jiaqing Xiang,Yongtao Han,Zhijian Chen,Haihua Yang,Jiaming Wang,Qingsong Pang,Xiao Zheng,Huanjun Yang,Tao Li,Florian Lordick,Xavier B. D’Journo,Robert J. Cerfolio,Robert J. Korst,Nuria M. Novoa,Scott J. Swanson,Alessandro Brunelli,Mahmoud Ismail,Hiran C. Fernando,Xu Zhang,Qun Li,Geng Wang,Baofu Chen,Teng Mao,Min Kong,Xufeng Guo,Ting Lin,Mengzhong Liu,Jianhua Fu +34 more
TL;DR: This trial shows that NCRT plus surgery improves survival over surgery alone among patients with locally advanced ESCC, with acceptable and manageable adverse events.
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Definitive chemoradiotherapy with FOLFOX versus fluorouracil and cisplatin in patients with oesophageal cancer (PRODIGE5/ACCORD17): final results of a randomised, phase 2/3 trial
Thierry Conroy,Marie-Pierre Galais,Jean-Luc Raoul,Olivier Bouché,Sophie Gourgou-Bourgade,Jean-Yves Douillard,Pierre-Luc Etienne,Valérie Boige,Isabelle Martel-Lafay,Pierre Michel,Carmen Llacer-Moscardo,Eric Francois,Gilles Créhange,Meher Ben Abdelghani,Beata Juzyna,Laurent Bedenne,Antoine Adenis +16 more
TL;DR: The PRODIGE5/ACCORD17 trial aimed to assess the efficacy and safety of the FOLFOX treatment regimen versus fluorouracil and cisplatin as part of chemoradiotherapy in patients with localised oesophageal cancer.
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Nivolumab Combination Therapy in Advanced Esophageal Squamous-Cell Carcinoma
TL;DR: In this paper , the authors compared first-line chemotherapy for advanced esophageal squamous-cell carcinoma with the monoclonal antibody nivolumab plus chemotherapy.
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Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline - Updated January 2017.
Jean-Marc Dumonceau,Pierre Henri Deprez,Christian Jenssen,Julio Iglesias-Garcia,Alberto Larghi,Geoffroy Vanbiervliet,Guruprasad P. Aithal,Paolo Giorgio Arcidiacono,Pedro Bastos,Silvia Carrara,László Czakó,Gloria Fernández-Esparrach,Paul Fockens,Angels Ginès,Roald Flesland Havre,Cesare Hassan,Peter Vilmann,Jeanin E. van Hooft,Marcin Polkowski +18 more
TL;DR: ESGE suggests performing EUS-guided sampling for the assessment of regional lymph nodes in T1 (and, depending on local treatment policy, T2) adenocarcinoma and of lesions suspicious for metastasis such as distant LNs, left liver lobe lesions, and suspected peritoneal carcinomatosis.
References
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ESPEN Guidelines for Nutrition Screening 2002
TL;DR: These guidelines deliberately make reference to the year 2002 in their title to indicate that this version is based on the evidence available until 2002 and that they need to be updated and adapted to current state of knowledge in the future.
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Capecitabine and oxaliplatin for advanced esophagogastric cancer.
TL;DR: Capecitabine and oxaliplatin are as effective as fluorouracil and cisplatin, respectively, in patients with previously untreated esophagogastric cancer, in a two-by-two design.
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Perioperative Chemotherapy Compared With Surgery Alone for Resectable Gastroesophageal Adenocarcinoma: An FNCLCC and FFCD Multicenter Phase III Trial
Marc Ychou,Valérie Boige,Jean-Pierre Pignon,Thierry Conroy,Olivier Bouché,Gilles Lebreton,Muriel Ducourtieux,Laurent Bedenne,Jean-Michel Fabre,B. Saint-Aubert,Jean Genève,Philippe Lasser,Philippe Rougier +12 more
TL;DR: In patients with resectable adenocarcinoma of the lower esophagus, GEJ, or stomach, perioperative chemotherapy using fluorouracil plus cisplatin significantly increased the curative resection rate, disease-free survival, and OS.
Journal ArticleDOI
Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus.
Jan B F Hulscher,Johanna W. van Sandick,Angela G. E. M. de Boer,Bas P. L. Wijnhoven,Jan G.P. Tijssen,Paul Fockens,Peep F. M. Stalmeier,Fiebo J.W. ten Kate,Herman van Dekken,Huug Obertop,Hugo W. Tilanus,J. Jan B. van Lanschot +11 more
TL;DR: Although median overall, disease-free, and quality-adjusted survival did not differ statistically between the groups, there was a trend toward improved long-term survival at five years with the extended transthoracic approach.
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Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis
Katrin Marie Sjoquist,Bryan Burmeister,B. Mark Smithers,B. Mark Smithers,John Zalcberg,R. John Simes,Andrew Barbour,Andrew Barbour,Val Gebski +8 more
TL;DR: This updated meta-analysis provides strong evidence for a survival benefit of neoadjuvant chemoradiotherapy or chemotherapy over surgery alone in patients with oesophageal carcinoma and investigates treatment effects by tumour histology and relations between risk (survival after surgery alone) and effect size.
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