Omeprazole inhibits IL-4 and IL-13 signaling signal transducer and activator of transcription 6 activation and reduces lung inflammation in murine asthma.

TLDR: The interaction among the 17q12-21 variants, childhood smoke exposure, and pediatric asthma in a white population is confirmed and the data show no age-of-onset effect; however, this study does not refute earlier findings suggesting such an effect.

Abstract: interaction was lacking. Of 10 SNPs evaluated, only rs8079416 was nominally significant at a P value of .01. There was no interaction with age or smoke exposure. This continues to suggest that the tagging SNPs are not linked strongly to the causal variant or that the causal variant is rare in this population. In conclusion, we confirm the interaction among the 17q12-21 variants, childhood smoke exposure, and pediatric asthma in a white population. However, our data show no age-of-onset effect. Although this study does not refute earlier findings suggesting such an effect, further prospective exploration of interaction between the 17q12-21 variants and age of onset is warranted. James H. Flory, MD, MS Patrick M. Sleiman, PhD Jason D. Christie, MD, MS Kiran Annaiah, MSc Jonathan Bradfield, BS Cecilia E. Kim, BA Joseph Glessner, MSc Marcin Imielinski, MD, PhD Hongzhe Li, PhD Edward C. Frackelton, BA Hou Cuiping, PhD George Otieno, MSc Kelly Thomas, BA Ryan Smith, BA Wendy Glaberson, BA Maria Garris, BA Rosetta Chiavacci, MSc Julian Allen, MD Jonathan Spergel, MD, PhD Robert Grundmeier, MD, PhD Michael Grunstein, MD, PhD Michael Magnusson, MD, PhD Struan F. A. Grant, PhD Klaus Bønnelykke, MD Hans Bisgaard, MD Hakon Hakonarson, MD, PhD From the Center for Applied Genomics, the Division of Pulmonary Medicine, the Division of Allergy and Immunology, the Department of Bioinformatics, and the Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, Pa; the Center for Clinical Epidemiology and Biostatistics, Department of Medicine, University of Pennsylvania, Philadelphia, Pa; and the Department of Health Sciences of the University of Copenhagen, Copenhagen, Denmark. E-mail: hakonarson@ CHOP.EDU. Disclosure of potential conflict of interest: J. H. Flory has received nonprofit grants from FOCUS, the University of Pennsylvania, and the National Institutes of Health. J. D. Christie receives grant support from the National Institutes of Health and has provided legal consultation/expert witness testimony in cases related to mesothelioma in brake workers. J. Allen receives grant support from the National Institutes of Health. J. Spergel receives grant support from Ception and is on the speakers’ bureau for Schering-Plough and AstraZeneca. R. Grundmeier receives grant support from the Agency for Healthcare Research and Quality. M. Magnusson has provided legal consultation/expert witness testimony in cases related to medical malpractice. S. F. A. Grant receives grant support from the National Institutes of Health. H. Bisgaard has been a consultant to and paid lecturer for and holds sponsored grants from Aerocrine, Altana, GlaxoSmithKline, Merck, MedImmune, NeoLab, and Pfizer and has provided legal consultation/expert witness testimony on behalf of NeoLab. The rest of the authors have declared that they have no conflict of interest.