Journal ArticleDOI
Oncogenetics and minimal residual disease are independent outcome predictors in adult patients with acute lymphoblastic leukemia.
Kheira Beldjord,Sylvie Chevret,Vahid Asnafi,Françoise Huguet,Marie-Laure Boulland,Thibaut Leguay,Xavier Thomas,Jean-Michel Cayuela,Nathalie Grardel,Yves Chalandon,Nicolas Boissel,Beat W. Schaefer,Eric Delabesse,Hélène Cavé,Patrice Chevallier,Agnes Buzyn,Thierry Fest,Oumedaly Reman,Jean-Paul Vernant,Véronique Lhéritier,Marie C. Béné,Marina Lafage,Elizabeth Macintyre,Norbert Ifrah,Hervé Dombret +24 more
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TLDR
It is indicated that genetic abnormalities are important predictors of outcome in adult ALL not fully recapitulated by early response to therapy, as assessed by immunoglobulin/T-cell receptor minimal residual disease (MRD) levels.About:
This article is published in Blood.The article was published on 2014-06-12. It has received 256 citations till now. The article focuses on the topics: Minimal residual disease & Adult Acute Lymphoblastic Leukemia.read more
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Journal ArticleDOI
Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia
Nicola Gökbuget,Hervé Dombret,Massimiliano Bonifacio,Albrecht Reichle,Carlos Graux,Christoph Faul,H. Diedrich,Max S. Topp,Monika Brüggemann,Heinz-August Horst,Violaine Havelange,Julia Stieglmaier,Hendrik Wessels,Vincent Haddad,Jonathan Benjamin,Gerhard Zugmaier,Dirk Nagorsen,Ralf C. Bargou +17 more
TL;DR: After treatment with blinatumomab in a population of patients with MRd-positive B-cell precursor ALL, a majority achieved a complete MRD response, which was associated with significantly longer RFS and OS compared with MRD nonresponders.
Journal ArticleDOI
Minimal residual disease diagnostics in acute lymphoblastic leukemia: need for sensitive, fast, and standardized technologies
TL;DR: Monitoring of minimal residual disease (MRD) has become routine clinical practice in frontline treatment of virtually all childhood acute lymphoblastic leukemia and in many adult ALL patients, and the efficacy of innovative drugs are currently being evaluated with MRD diagnostics within clinical trials.
Journal ArticleDOI
Association of Minimal Residual Disease With Clinical Outcome in Pediatric and Adult Acute Lymphoblastic Leukemia: A Meta-analysis.
Donald A. Berry,Shouhao Zhou,Howard R. Higley,Lata Mukundan,Shuangshuang Fu,Gregory H. Reaman,Brent L. Wood,Gary J. Kelloff,J. Milburn Jessup,Jerald P. Radich +9 more
TL;DR: The value of having achieved MRD negativity is substantial in both pediatric and adult patients with ALL and warrants consideration as an early measure of disease response for evaluating new therapies, improving the efficiency of clinical trials, accelerating drug development, and for regulatory approval.
Journal ArticleDOI
Acute lymphoblastic leukaemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†
Dieter Hoelzer,Renato Bassan,Hervé Dombret,Adele K. Fielding,Josep-Maria Ribera,Christian Buske +5 more
TL;DR: This paper presents the results of a meta-analyses conducted at the 2015 European Hematology Congress (ESMO) at the invitation of the ESMO Guidelines Committee, which confirmed the high level of confidence in the results obtained in the studies reported in this paper.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
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Regression Models and Life-Tables
TL;DR: The analysis of censored failure times is considered in this paper, where the hazard function is taken to be a function of the explanatory variables and unknown regression coefficients multiplied by an arbitrary and unknown function of time.
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Applied Linear Regression Models
TL;DR: In this article, a simple linear regression with one predictor variable variable is proposed for time series data, where the predictor variable is a linear regression model with a single predictor variable and the regression model is a combination of linear regression and regression with multiple predictors.
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Asymptotically Efficient Rank Invariant Test Procedures
Richard Peto,Julian Peto +1 more
Journal ArticleDOI
Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936.
J. J. M. Van Dongen,Anthonie Willem Langerak,Monika Brüggemann,Paul Evans,Michael Hummel,F. L. Lavender,Eric Delabesse,Frederic Davi,Ed Schuuring,Ramón García-Sanz,J.H.J.M. van Krieken,J Droese,David Gonzalez,Christian Bastard,Helen E. White,Marcel Spaargaren,Marcos González,A Parreira,John L. Smith,Gareth J. Morgan,Michael Kneba,Elisabeth Macintyre +21 more
TL;DR: The BIOMED-2 multiplex tubes can now be used for diagnostic clonality studies as well as for the identification of PCR targets suitable for the detection of minimal residual disease.
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