Journal ArticleDOI
One pot synthesis of monodisperse water soluble iron oxide nanocrystals with high values of the specific absorption rate
Pablo Guardia,Andreas Riedinger,Simone Nitti,Giammarino Pugliese,Sergio Marras,Alessandro Genovese,Maria Elena Materia,Christophe Lefevre,Liberato Manna,Teresa Pellegrino +9 more
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TLDR
A highly reproducible route to synthesize iron oxide nanoparticles (IONPs) with control over size and shape and with size dispersions around 10%, which uncovers the possibility of using large IONPs for magnetic hyperthermia in tumor therapy.Abstract:
We report a highly reproducible route to synthesize iron oxide nanoparticles (IONPs) with control over size and shape and with size dispersions around 10%. By tuning the relative ratio of squalane to dibenzyl ether, which were used as solvents in the synthesis, the size of the particles could be varied from 14 to around 100 nm, while their shape evolved from cubic (for size ranges up to 35 nm) to truncated octahedra and octahedra (for sizes from 40 nm up to 100 nm). Fine tuning of the size within each of these ranges could be achieved by varying the heating ramp and the iron precursor to decanoic acid ratio. We also demonstrate direct water transfer of the as-synthesized IONPs via in situ ligand exchange with gallol polyethylene glycol molecules, the latter simply added to the crude nanocrystal mixture at 70 °C. The specific absorption rate (SAR) values measured on the water transferred IONPs, at frequencies and applied magnetic fields that are considered safe for patients, confirmed their high heating performance. Finally, this method allows the transfer of 35 nm nanocubes as individually coated and stable particles to the water phase. For the first time, the heating performance of such large IONPs has been studied. This work uncovers the possibility of using large IONPs for magnetic hyperthermia in tumor therapy.read more
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Duality of Iron Oxide Nanoparticles in Cancer Therapy: Amplification of Heating Efficiency by Magnetic Hyperthermia and Photothermal Bimodal Treatment
Ana Espinosa,Riccardo Di Corato,Jelena Kolosnjaj-Tabi,Patrice Flaud,Teresa Pellegrino,Claire Wilhelm +5 more
TL;DR: It is reported that iron oxide nanoparticles have the dual capacity to act as both magnetic and photothermal agents, and single-mode treatments (magnetic or laser hyperthermia) reduced tumor growth, while DUAL-mode treatment resulted in complete tumor regression.
Journal ArticleDOI
Designed synthesis and surface engineering strategies of magnetic iron oxide nanoparticles for biomedical applications
TL;DR: This review outlines the limitations of extant surface engineering strategies and several developing strategies that may overcome these limitations and details the promising future directions of this active research field.
Journal ArticleDOI
Size-Dependent Heating of Magnetic Iron Oxide Nanoparticles
TL;DR: It is shown that MIONs with large sizes (>20 nm) have a specific absorption rate (SAR) significantly higher than that predicted by the widely used linear theory of MFH, which offers important insight into the rationale design of MION-based MFH for therapeutic applications.
Journal ArticleDOI
Design Strategies for Shape-Controlled Magnetic Iron Oxide Nanoparticles
Alejandro G. Roca,Lucía Gutiérrez,Lucía Gutiérrez,Helena Gavilán,Maria Eugênia Fortes Brollo,Sabino Veintemillas-Verdaguer,María del Puerto Morales +6 more
TL;DR: This review is focused on the synthesis routes for the production of uniform anisometric magnetite/maghemite nanoparticles with different morphologies like cubes, rods, disks, flowers and many others, such as hollow spheres, worms, stars or tetrapods.
Journal ArticleDOI
The One Year Fate of Iron Oxide Coated Gold Nanoparticles in Mice
Jelena Kolosnjaj-Tabi,Jelena Kolosnjaj-Tabi,Yasir Javed,Lenaic Lartigue,Jeanne Volatron,Dan Elgrabli,Iris Marangon,Giammarino Pugliese,Benoit Caron,Albert Figuerola,Nathalie Luciani,Teresa Pellegrino,Damien Alloyeau,Florence Gazeau +13 more
TL;DR: Modulation of nanoparticles reactivity to the biological environment by the choice of materials and surface functionalization may provide new directions in the design of multifunctional nanomedicines with predictable fate.
References
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Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Xavier Michalet,Fabien Pinaud,Laurent A. Bentolila,James M. Tsay,Sören Doose,J. Jack Li,Gobalakrishnan Sundaresan,Anna M. Wu,Sanjiv S. Gambhir,Sanjiv S. Gambhir,Shimon Weiss +10 more
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Ultra-large-scale syntheses of monodisperse nanocrystals.
Jongnam Park,Kwangjin An,Yosun Hwang,Je-Geun Park,Han-Jin Noh,Jae Young Kim,Jae-Hoon Park,Nong-Moon Hwang,Taeghwan Hyeon +8 more
TL;DR: This work is able to synthesize as much as 40 g of monodisperse nanocrystals in a single reaction, without a size-sorting process, and the particle size could be controlled simply by varying the experimental conditions.
Journal ArticleDOI
Monodisperse MFe2O4 (M = Fe, Co, Mn) Nanoparticles
Shouheng Sun,Hao Zeng,David B. Robinson,Simone Raoux,Philip M. Rice,Shan X. Wang,Guanxiong Li +6 more
TL;DR: As-synthesized iron oxide nanoparticles have a cubic spinel structure as characterized by HRTEM, SAED, and XRD and can be transformed into hydrophilic ones by adding bipolar surfactants, and aqueous nanoparticle dispersion is readily made.
Journal ArticleDOI
The use of nanocrystals in biological detection
TL;DR: The emerging ability to control the patterns of matter on the nanometer length scale can be expected to lead to entirely new types of biological sensors capable of sensing at the single-molecule level in living cells, and capable of parallel integration for detection of multiple signals.
Journal ArticleDOI
Size-Controlled Synthesis of Magnetite Nanoparticles
Shouheng Sun,Hao Zeng +1 more
TL;DR: The reported procedure can be used as a general approach to various ferrite nanoparticles and nanoparticle superlattices.