Journal ArticleDOI
Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells
Ian J. Majewski,Matthew E. Ritchie,Belinda Phipson,Jason Corbin,Miha Pakusch,Anja Ebert,Meinrad Busslinger,Haruhiko Koseki,Yifang Hu,Gordon K. Smyth,Warren S. Alexander,Douglas J. Hilton,Marnie E. Blewitt +12 more
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TLDR
It is shown that mice with loss of function mutations in PRC2 components display enhanced HSC/progenitor population activity, whereas mutations that disrupt PRC1 or pleiohomeotic repressive complex are associated with HSC or progenitor cell defects.About:
This article is published in Blood.The article was published on 2010-08-05. It has received 131 citations till now. The article focuses on the topics: Progenitor cell & Stem cell.read more
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The role of histone methyltransferase EZH2 in myelodysplastic syndromes
TL;DR: The molecular mechanisms of EZH2 in tumorigenesis and the role of E zh2 in MDS are studied to improve epigenetic therapy in M DS.
Journal ArticleDOI
Transcriptome analysis of genes regulated by cholesterol loading in two strains of mouse macrophages associates lysosome pathway and ER stress response with atherosclerosis susceptibility.
TL;DR: Three transcripts were highly up-regulated by cholesterol in AKR and either down-regulated or unchanged in loaded DBA/2 macrophages, thus associated a robust ER stress response with atherosclerosis resistance.
BookDOI
The Genetic Basis of Haematological Cancers: Tosi/The Genetic Basis of Haematological Cancers
Silvano Tosi,Alistair Reid +1 more
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Replacement of dietary soy- with air classified faba bean protein concentrate alters the hepatic transcriptome in Atlantic salmon (Salmo salar) parr.
TL;DR: This study demonstrated a dose-dependent metabolic response to a plant ingredient and was the first to compare the nutrigenomic transcriptional responses after substitution of terrestrial feed ingredients such as BPC and SPC without withdrawal of marine ingredients.
Journal ArticleDOI
Polycomb complexes redundantly maintain epidermal stem cell identity during development
Idan Cohen,Carmit Bar,Hequn Liu,Víctor Valdés,Dejian Zhao,Dejian Zhao,Phillip M. Galbo,Jose M. Silva,Haruhiko Koseki,Deyou Zheng,Elena Ezhkova +10 more
TL;DR: The functional contribution of PRC1 and PRC2 to gene repression has been a subject of debate, and understanding of its physiological significance requires further studies as discussed by the authors, using the developing murine epidermis as a paradigm, uncovered a previously unappreciated functional redundancy between Polycomb complexes.
References
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Journal ArticleDOI
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
Aravind Subramanian,Pablo Tamayo,Vamsi K. Mootha,Sayan Mukherjee,Benjamin L. Ebert,Michael A. Gillette,Amanda G. Paulovich,Scott L. Pomeroy,Todd R. Golub,Eric S. Lander,Jill P. Mesirov +10 more
TL;DR: The Gene Set Enrichment Analysis (GSEA) method as discussed by the authors focuses on gene sets, that is, groups of genes that share common biological function, chromosomal location, or regulation.
Journal ArticleDOI
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
TL;DR: The hierarchical model of Lonnstedt and Speed (2002) is developed into a practical approach for general microarray experiments with arbitrary numbers of treatments and RNA samples and the moderated t-statistic is shown to follow a t-distribution with augmented degrees of freedom.
Journal ArticleDOI
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao,Liangjun Wang,Hengbin Wang,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Richard S. Jones,Yi Zhang +7 more
TL;DR: The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Journal ArticleDOI
Polycomb complexes repress developmental regulators in murine embryonic stem cells
Laurie A. Boyer,Kathrin Plath,Kathrin Plath,Julia Zeitlinger,Tobias Brambrink,Lea Ann Medeiros,Tong Ihn Lee,Stuart S. Levine,Marius Wernig,Adriana Tajonar,Mridula K. Ray,George W. Bell,Arie P. Otte,Miguel Vidal,David K. Gifford,Richard A. Young,Rudolf Jaenisch +16 more
TL;DR: It is shown that PcG proteins directly repress a large cohort of developmental regulators in murine ES cells, the expression of which would otherwise promote differentiation, and dynamic repression of developmental pathways by Polycomb complexes may be required for maintaining ES cell pluripotency and plasticity during embryonic development.
Journal ArticleDOI
Control of developmental regulators by Polycomb in human embryonic stem cells.
Tong Ihn Lee,Richard G. Jenner,Laurie A. Boyer,Matthew G. Guenther,Stuart S. Levine,Roshan M. Kumar,Brett Chevalier,Sarah E. Johnstone,Megan F. Cole,Kyoichi Isono,Haruhiko Koseki,Takuya Fuchikami,Kuniya Abe,Heather L. Murray,Jacob P. Zucker,Bingbing Yuan,George W. Bell,Elizabeth Herbolsheimer,Nancy M. Hannett,Kaiming Sun,Duncan T. Odom,Arie P. Otte,Thomas L. Volkert,David P. Bartel,Douglas A. Melton,David K. Gifford,David K. Gifford,Rudolf Jaenisch,Richard A. Young +28 more
TL;DR: It is found that PRC2 target genes are preferentially activated during ES cell differentiation and that the ES cell regulators OCT4, SOX2, and NANOG cooccupy a significant subset of these genes.
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