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Open AccessJournal ArticleDOI

Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2)

TLDR
The ability of employing zeta potential to target drug delivery systems to, and drug release at specific sites of the body are discussed.
Abstract
The zeta potential (ZP) of colloidal systems and nano-medicines, as well as their particle size exert a major effect on the various properties of nano-drug delivery systems. Not only the stability of dosage forms and their release rate are affected but also their circulation in the blood stream and absorption into body membranes are dramatically altered by ZP. In this paper the effect of ZP on the various properties of nano-medicines are reviewed. Furthermore, the ability of employing zeta potential to target drug delivery systems to, and drug release at specific sites of the body are discussed.

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Nanomedicine review: clinical developments in liposomal applications

TL;DR: Liposomal formulations are less toxic than drugs alone and have better pharmacological parameters, although they seem to be the first choice for drug delivery systems for various diseases, further research about dosage regimen regarding dose and time needs to be carried out.
Journal ArticleDOI

Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions.

TL;DR: In this paper, a review of different characterization techniques for polymeric micelles is presented, from the ones used for the determination of micells basic characteristics (critical micellar concentration, size, surface charge, morphology) to the more complex approaches used to figure out micellers kinetic stability, drug release and behavior in the presence of biological substrates (fluids, cells and tissues).
Journal ArticleDOI

Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer’s Disease

TL;DR: Evidence is provided that grape skin and grape seed extracts increase the inhibition effect on Aβ aggregation, and solid lipid nanoparticles functionalized with an antibody, the anti-transferrin receptor monoclonal antibody (OX26 mAb), can work as a possible carrier to transport the extract to target the brain.
Journal ArticleDOI

Zeta potential: a case study of cationic, anionic, and neutral liposomes.

TL;DR: A strong linear relationship was noted between zeta potential values and the mole percentage of charged lipids within a liposome (e.g., cationic DOTAP or anionic DOPS), which could be used to formulate similar liposomes to a specific zeta Potential, potentially of importance for systems sensitive to highly charged species.
References
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Journal ArticleDOI

Nanoparticle therapeutics: an emerging treatment modality for cancer

TL;DR: The features of nanoparticle therapeutics that distinguish them from previous anticancer therapies are highlighted, and how these features provide the potential for therapeutic effects that are not achievable with other modalities are described.
Journal ArticleDOI

Biodegradable nanoparticles for drug and gene delivery to cells and tissue

TL;DR: Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.
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Nanoparticles in cancer therapy and diagnosis

TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI

Functions of Cell Surface Heparan Sulfate Proteoglycans

TL;DR: Current analyses of genetic defects in Drosophila melanogaster, mice, and humans confirm most of these activities in vivo and identify additional processes that involve cell surface heparan sulfate proteoglycans.
Journal ArticleDOI

Recent advances on chitosan-based micro- and nanoparticles in drug delivery.

TL;DR: The present review outlines the major new findings on the pharmaceutical applications of chitosan-based micro/nanoparticulate drug delivery systems published over the past decade and discusses critically the usefulness of these systems in delivering the bioactive molecules.
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