Journal ArticleDOI
Ordered shotgun sequencing, a strategy for integrated mapping and sequencing of YAC clones.
Reads0
Chats0
TLDR
Simulations support the feasibility of ordered shotgun sequencing and indicate that during the generation of the complete sequence, the approach facilitates the early choice of regions for selective sequencing, for example, for coding units.About:
This article is published in Genomics.The article was published on 1993-09-01. It has received 56 citations till now. The article focuses on the topics: Shotgun sequencing & Contig.read more
Citations
More filters
Journal ArticleDOI
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
TL;DR: Using linkage-disequilibrium and full haplotype analysis, this paper identified a 250-kilobase region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.
Journal Article
A novel MHC class-I-like gene is mutated in patients with hereditary haemochromatosis
TL;DR: Using linkage–disequilibrium and full haplotype analysis, a region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical–by–descent in 85% of patient chromosomes is identified, containing a gene related to the MHC class I family, termed HLA–H, containing two missense alterations.
Journal ArticleDOI
The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy
Natalie Roy,Natalie Roy,Mani S. Mahadevan,Michael Mclean,Michael Mclean,Gary Shutter,Zahra Yaraghi,Zahra Yaraghi,Reza Farahani,Reza Farahani,Stephen Baird,Anne Besner-Johnston,Charles Lefebvre,Charles Lefebvre,Xiaolin Kang,Xiaolin Kang,Maysoon Salih,Huguette L. Aubry,Katsuyuki Tamai,Xiaoping Guan,Panayiotis A. Ioannou,Thomas O. Crawford,Pieter J. de Jong,Linda C. Surh,Joh-E Ikeda,Joh-E Ikeda,Robert G. Korneluk,Robert G. Korneluk,Alex MacKenzie,Alex MacKenzie +29 more
TL;DR: It is suggested that mutations in the NAIP locus may lead to a failure of a normally occurring inhibition of motor neuron apoptosis resulting in or contributing to the SMA phenotype.
Journal ArticleDOI
The complete sequence of the mucosal pathogen Ureaplasma urealyticum
John I. Glass,John I. Glass,Elliot J. Lefkowitz,Jennifer S. Glass,Jennifer S. Glass,Cheryl R. Heiner,Cheryl R. Heiner,Ellson Y. Chen,Ellson Y. Chen,Gail H. Cassell,Gail H. Cassell +10 more
TL;DR: The complete sequence of a more distant phylogenetic relative of those bacteria, Ureaplasma urealyticum (parvum biovar), is reported, which is the third mycoplasma to be sequenced, and has the smallest sequenced prokaryotic genome except for M. genitalium.
Journal ArticleDOI
Human whole-genome shotgun sequencing.
James L. Weber,Eugene W. Myers +1 more
TL;DR: This article outlines an alternative approach to sequencing the human and other large genomes, which it is argued is less costly and more informative than the clone-by-clone approach.