Journal ArticleDOI
Organic fluorescent probes for detecting mitochondrial membrane potential
TLDR
This critical review may promote the development of more robust MMP fluorescent probes, providing more powerful tools for researching basic biology to improve cancer diagnoses and treatments in clinics in the future.About:
This article is published in Coordination Chemistry Reviews.The article was published on 2020-10-01. It has received 53 citations till now.read more
Citations
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A Single Fluorescent pH Probe for Simultaneous Two-Color Visualization of Nuclei and Mitochondria and Monitoring Cell Apoptosis
TL;DR: In this paper, a pH-sensitive fluorescent probe (HMBI) was proposed for simultaneous and discriminable visualization of different organelles and their dynamics during certain bioprocess.
Journal ArticleDOI
Tetraphenylene-chalcone hybrid derivatives: Synthesis, structural, fluorescence properties and imaging in living cells
TL;DR: Tetraphenylene-chalcones hybrid derivatives have been designed and synthesized, and their optical properties have also been investigated as mentioned in this paper, and it has been further demonstrated that these organic fluorophores can be employed for imaging in living cells.
Journal ArticleDOI
Optical/electrochemical methods for detecting mitochondrial energy metabolism
TL;DR: In this article , the authors highlight the biological importance of mitochondrial energy metabolism and the applications of multiple optical/electrochemical approaches to determine energy metabolites, and summarise the mitochondrial structure, functions, and crucial energy metabolic signalling pathways.
Journal ArticleDOI
Optical/electrochemical methods for detecting mitochondrial energy metabolism
Vivekanand Sadashiv Vadke,Wenhui Ji,Silvan Imhof,Xiao Tang,X. Li,Wei Du,Yao Lu,Nanxiang Wang,Qiong Wu,Wei Wei,Jie Liu,Hai-Dong Yu,Bo Ma,Lin Li,Lin Li,Lin Li,Huang Wei,Huang Wei,Huang Wei +18 more
TL;DR: In this article, the authors highlight the biological importance of mitochondrial energy metabolism and the applications of multiple optical/electrochemical approaches to determine energy metabolites, and summarise the mitochondrial structure, functions, and crucial energy metabolic signalling pathways.
Journal ArticleDOI
A Continuous Add-On Probe Reveals the Nonlinear Enlargement of Mitochondria in Light-Activated Oncosis.
Kangnan Wang,Xintian Shao,Xintian Shao,Zhiqi Tian,Liu-Yi Liu,Chengying Zhang,Chengying Zhang,Cai-Ping Tan,Jie Zhang,Peixue Ling,Fei Liu,Qixin Chen,Qixin Chen,Jiajie Diao,Zong-Wan Mao +14 more
TL;DR: In this paper, a dual-labeled probe, MitoMN, and a continuous add-on assay are designed to image the dynamic process of mitochondria in conditions that are unobservable with current mitochondrial probes.
References
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Journal ArticleDOI
Mitochondria and apoptosis
Douglas R. Green,John C. Reed +1 more
TL;DR: A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins.
Journal ArticleDOI
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Michael T. Lin,M. Flint Beal +1 more
TL;DR: Treatments targeting basic mitochondrial processes, such as energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria hold great promise in ageing-related neurodegenerative diseases.
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Mitochondria: In Sickness and in Health
TL;DR: This work provides a current view of how mitochondrial functions impinge on health and disease and identifies mitochondrial dysfunction as a key factor in a myriad of diseases, including neurodegenerative and metabolic disorders.
Journal ArticleDOI
Mechanisms by which mitochondria transport calcium.
Thomas E. Gunter,D. R. Pfeiffer +1 more
TL;DR: It has been suggested that the permeability transition and its reversal may also function as a mitochondrial Ca2+ efflux mechanism under some conditions.
Journal ArticleDOI
Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.
Stephen T. Smiley,Martin Reers,Cristina Mottola-Hartshorn,Mei Lin,A. P. Chen,Thomas W. Smith,Glenn Steele,Lan Bo Chen +7 more
TL;DR: It is found that membrane potentials across mitochondria in a living cell can be heterogeneous, and even within a long contiguous mitochondrion, regional heterogeneity in membranes potentials appears to be possible.