Patients with schizophrenia have decreased COVID-19 prevalence among hospitalised patients with psychiatric and neurological diseases: A retrospective analysis in Mexican population.
Ángel Roberto Rivas-Ramírez,Hiram Tendilla-Beltrán,Laura Eréndira Gómez-Mendoza,Guillermo Loaiza,Gonzalo Flores +4 more
TLDR
In this article, the authors analyzed the clinical records of 198 patients with psychiatric and neurological disorders hospitalised in the Dr Rafael Serrano Psychiatric Hospital in Puebla during the peak of the first wave of the COVID-19 pandemic in Mexico were analyzed for psychiatric or neurologic diagnosis, gender, age, medical diagnosis, and COVID19 prevalence.Abstract:
Background Increased coronavirus disease 2019 (COVID-19) incidence and mortality in hospitalised patients with psychiatric and neurologic disorders have been reported. Methods The clinical records of 198 patients with psychiatric and neurological disorders hospitalised in the Dr Rafael Serrano Psychiatric Hospital in Puebla during the peak of the first wave of the COVID-19 pandemic in Mexico were analysed for psychiatric or neurologic diagnosis, gender, age, medical diagnosis, and COVID-19 prevalence. For patients with COVID-19, the effects of gender, and medical diagnosis were explored. Results There was an increased COVID-19 prevalence in the studied population (43.94%), compared with the national Mexican (~0.21% to 0.63%) and worldwide average in the general population (~0.13% to 4.28%). However, the mortality rate (5.75%) was lower than that reported in Mexico (11.28%-13.55%), which was higher than the worldwide average (2.95%-4.98%). We detected increased COVID-19 prevalence in patients with comorbidities (odds ratios [OR] 0.4; 95% CI: 0.2-1, P = .0447). Moreover, patients with schizophrenia spectrum disorders have a decreased predisposition to COVID-19 (OR 0.4, 95% CI: 0.2-0.8; P = .0250), as opposed to patients with intellectual disability that are predisposed to COVID-19 (OR 2.2, 95% CI: 0.2-0.8; P = .0434), in comparison with the rest of the hospital population. Conclusion The prevalence of COVID-19 in hospitalised patients with psychiatric disorders is increased compared with that of the general population; however, a lower mortality rate was detected. Also, an increased risk of COVID-19 was detected in patients with comorbidities. Interestingly, the observed variation in COVID-19 prevalence in patients with schizophrenia and intellectual disability was not associated with age or other specific medical diagnoses.read more
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Long covid, neuropsychiatric disorders, psychotropics, present and future.
TL;DR: Early reports of protective effects of psychotropics against COVID-19 need to be validated, and reports of reduced number of sigma-1 receptors in post- mortem schizophrenic brains and the reported roles of s Sigma and histamine receptors in neuroinflammation and viral infections may point to an important and novel direction for drug discovery against CO VID-19.
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Mortality from coronavirus disease 2019 (Covid-19) in patients with schizophrenia: A systematic review, meta-analysis and meta-regression
Engelberta Pardamean,Waskita Roan,Karina Terry Amartini Iskandar,Regina Prayangga,Timotius Ivan Hariyanto +4 more
TL;DR: In this article , the authors investigated whether patients with pre-existing schizophrenia are at higher risk for Covid-19 mortality and found that the increased risk of developing mortality from Covid19 in patients with schizophrenia was significantly influenced by older age (p = 0.0004) and smoking.
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Increased suicide rates in Mexico City during the COVID-19 pandemic outbreak: An analysis spanning from 2016 to 2021
Fernando García-Dolores,Hiram Tendilla-Beltrán,Roberto Cuauhtemoc Mendoza-Morales,Laura Eréndira Gómez-Mendoza,Andrea Judith Vázquez-Hernández,F. De La Cruz,Alma Delia Genis-Mendoza,Humberto Nicolini,Gonzalo Flores +8 more
TL;DR: In this paper , the authors examined suicide characteristics before and during the COVID-19 pandemic in Mexico City and found that suicide is a complex and multifactorial problem and will allow the establishment of new guidelines for prevention and care strategies.
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TL;DR: This is the first nationwide, cross-specialty surveillance study of acute neurological and psychiatric complications of COVID-19 and provides valuable and timely data that are urgently needed by clinicians, researchers, and funders.
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Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA
Maxime Taquet,Maxime Taquet,Sierra Luciano,John R. Geddes,John R. Geddes,Paul Harrison,Paul Harrison +6 more
TL;DR: Survivors of COVID-19 appear to be at increased risk of psychiatric sequelae, and a psychiatric diagnosis might be an independent risk factor for COIDs, according to a preliminary study using data from 69 million patients.
Journal ArticleDOI
How mental health care should change as a consequence of the COVID-19 pandemic.
Carmen Moreno,Til Wykes,Til Wykes,Silvana Galderisi,Merete Nordentoft,Nicholas Crossley,Nev Jones,Mary Cannon,Christoph U. Correll,Christoph U. Correll,Louise Byrne,Louise Byrne,Sarah Carr,Eric Y.H. Chen,Philip Gorwood,Sonia Johnson,Hilkka Kärkkäinen,John H. Krystal,Jimmy Chee Keong Lee,Jeffrey A. Lieberman,Carlos López-Jaramillo,Miia Männikkö,Michael Phillips,Hiroyuki Uchida,Eduard Vieta,Antonio Vita,Celso Arango +26 more
TL;DR: The interconnectedness of the world made society vulnerable to this infection, but it also provides the infrastructure to address previous system failings by disseminating good practices that can result in sustained, efficient, and equitable delivery of mental health-care delivery.
Journal ArticleDOI
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.
Jenny Meinhardt,Josefine Radke,Carsten Dittmayer,Jonas Franz,Jonas Franz,Carolina Thomas,Carolina Thomas,Ronja Mothes,Michael Laue,Julia Schneider,Sebastian Brünink,Selina Greuel,Malte Lehmann,Olga Hassan,Tom Aschman,Elisa Schumann,Robert Lorenz Chua,Christian Conrad,Roland Eils,Roland Eils,Werner Stenzel,Marc Windgassen,Larissa Rößler,Hans-Hilmar Goebel,Hans R. Gelderblom,Hubert Martin,Andreas Nitsche,Walter J. Schulz-Schaeffer,Samy Hakroush,Martin Sebastian Winkler,Björn Tampe,Franziska Scheibe,Peter Körtvelyessy,Peter Körtvelyessy,Dirk Reinhold,Britta Siegmund,Anja A. Kühl,Sefer Elezkurtaj,David Horst,Lars Oesterhelweg,Michael Tsokos,Barbara Ingold-Heppner,Christine Stadelmann,Christian Drosten,Victor M. Corman,Helena Radbruch,Frank L. Heppner +46 more
TL;DR: The morphological changes associated with infection such as thromboembolic ischemic infarction of the CNS and evidence of SARS-CoV-2 neurotropism are described and presented.