PDZ and LIM domain protein 1(PDLIM1)/CLP36 promotes breast cancer cell migration, invasion and metastasis through interaction with α-actinin
TLDR
It is shown here that CLP36 is critical for promoting breast cancer cell migration and invasion in vitro and metastasis in vivo, whereas it is dispensable for breast cell proliferation and anchorage-independent growth in vitroand tumor growth in vivo.Abstract:
Increased CLP36 expression has been found to be closely associated with breast cancer progression. However, whether and how it contributes to malignant behavior of breast cancer cells were not known. We show here that CLP36 is critical for promoting breast cancer cell migration and invasion in vitro and metastasis in vivo, whereas it is dispensable for breast cell proliferation and anchorage-independent growth in vitro and tumor growth in vivo. CLP36 interacted with both α-actinin-1 and -4 in breast cancer cells. Depletion of either α-actinin-1 or -4 inhibited breast cancer cell migration. Furthermore, mutations inhibiting the α-actinin-binding activity abolished the ability of CLP36 to promote breast cancer cell migration. Finally, depletion of CLP36 or disruption of the CLP36-α-actinin complex in breast cancer cells substantially inhibited Cdc42 activation, cell polarization and migration. Our results identify CLP36 as an important regulator of breast cancer cell migration and metastasis, and shed light on how increased CLP36 expression contributes to the progression of breast cancer.read more
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Actinin-4 as a Diagnostic Biomarker in Serum of Breast Cancer Patients.
TL;DR: ACTN4 in serum can serve as a clinical predictor in the diagnosis or prediction of clinical outcomes of patients with BC, as well as the association between ACTN4 levels and clinicopathological features.
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Serum Anti-PDLIM1 Autoantibody as Diagnostic Marker in Ovarian Cancer.
Cuipeng Qiu,Yaru Duan,Bofei Wang,Jianxiang Shi,Peng Wang,Hua Ye,Liping Dai,Jianying Zhang,Xiao Wang +8 more
TL;DR: In this article, the diagnostic value of autoantibody against PDLIM1 for improving the detection of ovarian cancer (OC) was evaluated by using immunohistochemistry (IHC) test in tissue array containing 280 OC tissues.
DissertationDOI
Estudio del nivel de estrés oxidativo y valoración de la expresión de genes relacionados en la Aterosclerosis Carotidea
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PDLIM1: Structure, function and implication in cancer.
TL;DR: PDLIM1, a member of the PDZ-LIM family, is a cytoskeletal protein and functions as a platform to form distinct protein complexes, thus participating in multiple physiological processes such as cytoskeleton regulation and synapse formation as mentioned in this paper.
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Androgen receptor signalling confers clonogenic and migratory advantages in urothelial cell carcinoma of the bladder.
Maria V. Luna-Velez,Jelmer J. Dijkstra,Marina A. Heuschkel,Frank Smit,Guillaume van de Zande,Dominique Smeets,J.P. Michiel Sedelaar,Michiel Vermeulen,Gerald W. Verhaegh,Jack A. Schalken +9 more
TL;DR: In this paper, the androgen receptor (AR) mRNA level is upregulated in a subset of UCC cases, and blockage of AR signalling reduced the cell migration potential of androgen-stimulated UMUC-3-AR cells.
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