Journal ArticleDOI
Peptides from gluten digestion: A comparison between old and modern wheat varieties.
TLDR
It is concluded that old wheat lines are not to be considered "safer" for subjects that are genetically predisposed to celiac disease, because old varieties analysed produced a higher quantity of peptides containing immunogenic and toxic sequences than modern ones.About:
This article is published in Food Research International.The article was published on 2017-01-01. It has received 61 citations till now. The article focuses on the topics: Gluten & Coeliac disease.read more
Citations
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Journal ArticleDOI
Pathogenesis of Celiac Disease and Other Gluten Related Disorders in Wheat and Strategies for Mitigating Them.
Natasha Sharma,Simran Bhatia,Venkatesh Chunduri,Satveer Kaur,Saloni Sharma,Payal Kapoor,Anita Kumari,Monika Garg +7 more
TL;DR: Following a life-long gluten-free diet by celiac disease and non-celiac gluten-sensitivity patients is very challenging as none of wheat cultivar or related species stands safe for consumption.
Journal ArticleDOI
Adverse Reactions to Wheat or Wheat Components.
TL;DR: The present review systematically describes the characteristics of wheat-related intolerances, including their etiology, prevalence, the components responsible, diagnosis, and strategies to reduce adverse reactions.
Journal ArticleDOI
Wheat (Triticum aestivum L.) Breeding from 1891 to 2010 Contributed to Increasing Yield and Glutenin Contents but Decreasing Protein and Gliadin Contents.
TL;DR: Agronomic characteristics, protein content and gluten composition of 60 German winter wheat cultivars first registered between 1891 and 2010 grown in three years were analyzed and found no evidence to support an increased immunostimulatory potential of modern winter wheat.
Journal ArticleDOI
Immunoreactive cereal proteins in wheat allergy, non-celiac gluten/wheat sensitivity (NCGS) and celiac disease
TL;DR: Multidisciplinary approaches toward a better understanding of the complex interactions between immunoreactive components in cereals and the human gastrointestinal and immune systems, including the contribution of gut microbiota, will be key to devising novel preventive and therapeutic strategies for at-risk individuals.
Journal ArticleDOI
Next-generation therapies for celiac disease: the gluten-targeted approaches
Miguel Ribeiro,Fernando M. Nunes,Marta Rodríguez-Quijano,José A. Carrillo,Gérard Branlard,Gilberto Igrejas,Gilberto Igrejas +6 more
TL;DR: The gluten detoxification technologies have shown promising results in clinical trials by attenuating the symptomatology associated with celiac disease, and include gluten-specific proteases, which are close to entering the market for use by patients who may have mistakenly ingested food contaminated with gluten.
References
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Journal ArticleDOI
Structural Basis for Gluten Intolerance in Celiac Sprue
Lu Shan,Øyvind Molberg,Isabelle Parrot,Felix Hausch,Ferda Filiz,Gary M. Gray,Ludvig M. Sollid,Chaitan Khosla +7 more
TL;DR: A 33-mer peptide was identified that has several characteristics suggesting it is the primary initiator of the inflammatory response to gluten in Celiac Sprue patients, and could be detoxified in in vitro and in vivo assays by exposure to a bacterial prolyl endopeptidase, suggesting a strategy for oral peptidase supplement therapy for CeliacSprue.
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Current approaches to diagnosis and treatment of celiac disease: An evolving spectrum☆
Alessio Fasano,Carlo Catassi +1 more
TL;DR: The current gold standard for the diagnosis of CD remains histologic confirmation of the intestinal damage in serologically positive individuals, and the keystone treatment of CD patients is a lifelong elimination diet in which food products containing gluten are avoided.
Journal ArticleDOI
Wheat flour constituents: how they impact bread quality, and how to impact their functionality
Hans Goesaert,Kristof Brijs,Wim S. Veraverbeke,Christophe M. Courtin,Kurt Gebruers,Jan A. Delcour +5 more
TL;DR: In this article, the authors provide the basics on the processability and quality determining wheat flour constituents and present common concepts on their fate during the breadmaking process as well as on approaches targeted to influence their functionality.
Journal ArticleDOI
Applicability of an in vitro digestion model in assessing the bioaccessibility of mycotoxins from food.
Carolien H.M. Versantvoort,Agnes G. Oomen,Erwin Van de Kamp,Cathy J.M. Rompelberg,Adriënne J.A.M. Sips +4 more
TL;DR: The in vitro digestion model, combined with Caco-2 cells, is a powerful experimental tool, which can aid to a more accurate risk assessment of ingested contaminants.
Journal ArticleDOI
Current concepts of celiac disease pathogenesis
TL;DR: In this paper, Tissue transglutaminase, which has been identified as the highly specific endomysial autoantigen, is released from cells during inflammation, and it may potentiate antigen presentation by HLA-DQ2 and DQ8 by deamidating or cross-linking gluten peptides.