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Journal ArticleDOI

PET-guided treatment in patients with advanced-stage Hodgkin's lymphoma (HD18): final results of an open-label, international, randomised phase 3 trial by the German Hodgkin Study Group.

Peter Borchmann, +35 more
- 23 Dec 2017 - 
- Vol. 390, Iss: 10114, pp 2790-2802
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TLDR
This open-label, randomised, parallel-group phase 3 trial investigated whether metabolic response determined by PET after two cycles of standard regimen eBEACOPP (PET-2) would allow adaption of treatment intensity, increasing it for PET-2-positive patients and reducing it forPET- 2-negative patients and showed non-inferiority in the 5-year progression-free survival estimates.
About: 
This article is published in The Lancet.The article was published on 2017-12-23. It has received 250 citations till now. The article focuses on the topics: Standard treatment & Procarbazine.

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Journal ArticleDOI

PET-adapted treatment for newly diagnosed advanced Hodgkin lymphoma (AHL2011): a randomised, multicentre, non-inferiority, phase 3 study

René-Olivier Casasnovas, +29 more
- 01 Feb 2019 - 
TL;DR: This study investigated whether PET monitoring during treatment could allow dose de-escalation by switching regimen (BEACOPPescalated to ABVD) in early responders without loss of disease control compared with standard treatment without PET monitoring.
Journal ArticleDOI

Hodgkin lymphoma, version 2.2020

Richard T. Hoppe, +33 more
- 01 Jun 2020 - 
TL;DR: The introduction of less toxic and more effective regimens has significantly advanced HL cure rates and this portion of the NCCN Guidelines focuses on the management of classic HL.
Journal ArticleDOI

Incorporation of brentuximab vedotin into first-line treatment of advanced classical Hodgkin's lymphoma: final analysis of a phase 2 randomised trial by the German Hodgkin Study Group

Dennis A. Eichenauer, +16 more
- 01 Dec 2017 - 
TL;DR: This trial modified the escalated BEACOPP regimen and implemented brentuximab vedotin with the aim to reduce toxic effects while maintaining the protocol's efficacy and presented the final analysis at a median follow-up of 17 months.
Journal ArticleDOI

PET-guided omission of radiotherapy in early-stage unfavourable Hodgkin lymphoma (GHSG HD17): a multicentre, open-label, randomised, phase 3 trial.

Peter Borchmann, +36 more
- 01 Feb 2021 - 
TL;DR: The German Hodgkin Study Group HD17 trial as discussed by the authors investigated whether radiotherapy can be omitted without loss of efficacy in patients who have a complete metabolic response after receiving two cycles of escalated doses of etoposide, cyclophosphamide, and doxorubicin.
Journal ArticleDOI

FDG-PET/CT in the management of lymphomas: current status and future directions.

Tarec Christoffer El-Galaly, +5 more
- 01 Oct 2018 - 
TL;DR: FDG‐PET/CT plays major roles in the various phases of management of lymphoma and constitutes a step towards the pursuit of personalized treatment.
References
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Journal ArticleDOI

A Prognostic Score for Advanced Hodgkin's Disease

Dirk Hasenclever, +1 more
- 19 Nov 1998 - 
TL;DR: The prognostic score developed may be useful in designing clinical trials for the treatment of advanced Hodgkin's disease and in making individual therapeutic decisions, but a distinct group of patients at very high risk could not be identified on the basis of routinely documented demographic and clinical characteristics.
Journal ArticleDOI

Results of a Pivotal Phase II Study of Brentuximab Vedotin for Patients With Relapsed or Refractory Hodgkin's Lymphoma

Anas Younes, +17 more
- 20 Jun 2012 - 
TL;DR: The ADC brentuximab vedotin was associated with manageable toxicity and induced objective responses in 75% of patients with relapsed or refractory HL after autologous stem-cell transplantation (auto-SCT).
Journal ArticleDOI

Early Interim 2-[18F]Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography Is Prognostically Superior to International Prognostic Score in Advanced-Stage Hodgkin's Lymphoma: A Report From a Joint Italian-Danish Study

Andrea Gallamini, +19 more
- 20 Aug 2007 - 
TL;DR: PET-2 overshadows the prognostic value of IPS and emerges as the single most important tool for planning of risk-adapted treatment in advanced HL.
Journal ArticleDOI

Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: a multicentre, multicohort, single-arm phase 2 trial

Anas Younes, +20 more
- 01 Sep 2016 - 
TL;DR: Nivolumab resulted in frequent responses with an acceptable safety profile in patients with classical Hodgkin's lymphoma who progressed after autologous stem-cell transplantation and brentuximab vedotin, and might be a new treatment option for a patient population with a high unmet need.
Journal ArticleDOI

Standard and Increased-Dose BEACOPP Chemotherapy Compared with COPP-ABVD for Advanced Hodgkin's Disease

Volker Diehl, +11 more
- 12 Jun 2003 - 
TL;DR: Investigation of three combinations of chemotherapy for advanced Hodgkin's disease found increased-dose BEACOPP resulted in better tumor control and overall survival than did COPP-ABVD and standard BEACopP.
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Adapted Treatment Guided by Interim PET-CT Scan in Advanced Hodgkin’s Lymphoma

Peter Johnson, +20 more
- 22 Jun 2016 - 

Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial

Andreas Engert, +30 more
- 12 May 2012 - 

Results of a trial of PET-directed therapy for early-stage Hodgkin's lymphoma.

John Radford, +16 more
- 22 Apr 2015 - 

Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification

Bruce D. Cheson, +6 more
- 20 Sep 2014 - 

Early Interim 2-[18F]Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography Is Prognostically Superior to International Prognostic Score in Advanced-Stage Hodgkin's Lymphoma: A Report From a Joint Italian-Danish Study

Andrea Gallamini, +19 more
- 20 Aug 2007 -