Journal ArticleDOI
Phosphatidylinositol 3-kinase (PI3K) inhibitors: a recent update on inhibitor design and clinical trials (2016–2020)
TLDR
In this paper, the PI3K/AKT/mTOR signaling pathway plays a central role in regulating cell growth and proliferation and plays a key role in cell proliferation and cell survival.Abstract:
Introduction: The phosphatidylinositol 3-kinase/protein kinase-B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway plays a central role in regulating cell growth and proliferation and...read more
Citations
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Journal ArticleDOI
The PI3K/Akt/mTOR pathway: A potential pharmacological target in COVID-19
TL;DR: In this article , the authors reviewed emerging data on the involvement of the PI3K/Akt/mTOR pathway in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the clinical studies investigating its tailored inhibition in COVID-19.
Journal ArticleDOI
The PI3K/Akt/mTOR pathway: a potential pharmacological target in COVID-19
Maria Sofia Basile,Eugenio Cavalli,James A. McCubrey,Jorge Hernández-Bello,José Francisco Muñoz-Valle,Paolo Fagone,Ferdinando Nicoletti +6 more
TL;DR: In this paper, the authors reviewed emerging data on the involvement of the PI3K/Akt/mTOR pathway in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the clinical studies investigating its tailored inhibition in COVID-19.
Journal ArticleDOI
Chemical and Structural Strategies to Selectively Target mTOR Kinase
TL;DR: In this article, a broad region of chemical space is covered for the development of highly selective ATP-competitive mTOR kinase inhibitors (TORKi), and the investigation of chemical substitutions and physicochemical properties has shed light on the compounds' ability to cross the blood brain barrier.
Journal ArticleDOI
Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma
Divya Jain,Yogesh Murti,Wasi Ullah Khan,Rajib Hossain,Mohammad Nabil Hossain,Krishn Kumar Agrawal,Rana Azeem Ashraf,Muhammad Torequl Islam,Pracheta Janmeda,Yasaman Taheri,Mohammed M. Alshehri,Sevgi Durna Daştan,Balakyz Yeskaliyeva,Aliya Kipchakbayeva,Javad Sharifi-Rad,William C. Cho +15 more
TL;DR: In this article, a review on natural bioactive compounds with their effect on hepatocarcinomas is presented, focusing on oxidative stress and FDA-approved signaling pathway inhibitors, along with chemotherapy and radiotherapy enhancers.
Journal ArticleDOI
Targeting the PI3K/AKT/mTOR Signaling Pathway in the Treatment of Human Diseases: Current Status, Trends, and Solutions.
TL;DR: A review of recent advances in ATP-competitive inhibitors, allosteric inhibitors, covalent inhibitors, and proteolysis-targeting chimeras against the PI3K/AKT/mTOR pathway is presented in this paper .
References
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Journal ArticleDOI
Re-epithelialization and immune cell behaviour in an ex vivo human skin model.
TL;DR: A novel wound model based on application of negative pressure and its effects for epidermal regeneration and immune cell behaviour is presented, which recapitulates the main features of epithelial wound regeneration, and can be applied for testing wound healing therapies and investigating underlying mechanisms.
Journal ArticleDOI
The phosphatidylinositol 3-Kinase AKT pathway in human cancer.
Igor Vivanco,Charles L. Sawyers +1 more
TL;DR: Small-molecule therapeutics that block PI3K signalling might deal a severe blow to cancer cells by blocking many aspects of the tumour-cell phenotype.
Journal ArticleDOI
AKT/PKB signaling: navigating downstream.
TL;DR: Those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration are discussed.
Journal ArticleDOI
High frequency of mutations of the PIK3CA gene in human cancers
Yardena Samuels,Zhenghe Wang,Alberto Bardelli,Natalie Silliman,Janine Ptak,Steve Szabo,Hai Yan,Adi F. Gazdar,Steven M. Powell,Gregory J. Riggins,James K V Willson,Sanford D. Markowitz,Kenneth W. Kinzler,Bert Vogelstein,Victor E. Velculescu +14 more
TL;DR: To determine if PI3Ks are genetically altered in tumorigenesis, they were sequenced in human for the first time and the results allowed us to assess the importance of phosphatidylinositol 3-kinases in neoplasia.
Journal ArticleDOI
Targeting the phosphoinositide 3-kinase pathway in cancer.
TL;DR: The potential of and challenges for the development of therapeutic agents that target this pathway in cancer are discussed and the potential and challenges in understanding of the PI3K pathway are highlighted.